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Functional ligand of integrin alpha-8/beta-1 in kidney development. Additionally we are shipping Nephronectin Antibodies (42) and Nephronectin Kits (12) and many more products for this protein.
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In zebrafish miR-378a-3p mimic injection or npnt knockdown by a morpholino oligomer caused an identical to glomerular disease phenotype.
Morpholino-mediated knockdown of Npnt prevents proper heart valve leaflet formation and trabeculation and results in greater than 85% lethality at 7 days post-fertilization.
Results show that Npnt is highly expressed in tooth germ, and localized in the basement membrane between dental epithelium and mesenchyme. The study indicates that Npnt plays a critical scaffold role in dental epithelial stem cell differentiation and proliferation, and regulates Sox2 expression during tooth development.
Low Nephronectin expression is associated with Metastatic Breast Carcinoma.
NPNT stimulates the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated kinase (MAPK) in endothelial cells. NPNT is a paracrine angiogenic factor and may play a role in pathological osteoporosis.
These results suggest novel mechanisms for Wnt3a-induced osteoblast proliferation and cell survival via Npnt gene expression
we found that bone morphogenic protein-2 (BMP-2), known as an osteogenesis inducing cytokine, strongly up-regulated the expression of Npnt mRNA in a murine skeletal muscle cell line (C2C12) via the BMP-SMAD signaling pathway
Nephronectin is capable of binding to heparan sulfate proteoglycans in basement membranes via the MAM domain.
These results indicate that Npnt plays an important role in the initiation of hepatitis by recruiting CD4(+) T cells or NKT cells into the foci of inflammation.
canonical TGF-b signaling through Smad2 regulates Npnt geneexpression in osteoblasts.
expression of a fragment containing the 3'-untranslated region (3'-UTR) of nephronectin in osteoblast progenitor cells MC3T3-E1 promoted cell differentiation
These results suggest that TNF-alpha inhibits POEM expression through the NF-kappaB signaling pathway and down-regulation of POEM influences the inhibition of osteoblast differentiation by TNF-alpha.
TGF-beta inhibited differentiation of osteoblasts transfected with various truncated Npnt constructs, suggesting that TGF-beta can exert a down-stream effect on Npnt function.
MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7
it was demonstrated that nephronectin promotes differentiation during osteoblast differentiation and the EGF-like repeats were essential.
results thus place nephronectin and alpha8beta1 integrin in a pathway that regulates Gdnf expression and is essential for kidney development
deregulation of Nephronectin expression plays a role in the development or progression of malignant melanoma.
These results indicate that the specific high-affinity binding of nephronectin to alpha8beta1 integrin is achieved by bipartite interaction of the integrin with the RGD motif and LFEIFEIER sequence.
Biopsies from patients with focal segmental glomerulosclerosis and membranous nephropathy had increased miR-378a-3p expression and reduced glomerular levels of NPNT.
Nephronectin (NPNT), a member of the epidermal growth factor (EGF) repeat superfamily proteins and a homologue of EGFL6, is expressed in osteoblasts. Intriguingly, the gene expression of NPNT is reduced in the bone of osteoporosis patients.
The expression of nephronectin was sufficient to discriminate DN from other kidney diseases with mesangial matrix expansion and nodular lesions.
Nephronectin is associated with the development of diabetic glomerulosclerosis.
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).
, nephronectin variant 1
, nephronectin variant 2
, preosteoblast EGF-like repeat protein with MAM domain