Nephronectin Proteins (NPNT)

Functional ligand of integrin alpha-8/beta-1 in kidney development. Additionally we are shipping Nephronectin Antibodies (42) and Nephronectin Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NPNT 114249 Q91V88
NPNT 255743 Q6UXI9
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Top Nephronectin Proteins at

Showing 4 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days

NPNT Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human ,

More Proteins for Nephronectin (NPNT) Interaction Partners

Zebrafish Nephronectin (NPNT) interaction partners

  1. In zebrafish miR-378a-3p mimic injection or npnt knockdown by a morpholino oligomer caused an identical to glomerular disease phenotype.

  2. Morpholino-mediated knockdown of Npnt prevents proper heart valve leaflet formation and trabeculation and results in greater than 85% lethality at 7 days post-fertilization.

Mouse (Murine) Nephronectin (NPNT) interaction partners

  1. Results show that Npnt is highly expressed in tooth germ, and localized in the basement membrane between dental epithelium and mesenchyme. The study indicates that Npnt plays a critical scaffold role in dental epithelial stem cell differentiation and proliferation, and regulates Sox2 expression during tooth development.

  2. Low Nephronectin expression is associated with Metastatic Breast Carcinoma.

  3. NPNT stimulates the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated kinase (MAPK) in endothelial cells. NPNT is a paracrine angiogenic factor and may play a role in pathological osteoporosis.

  4. These results suggest novel mechanisms for Wnt3a-induced osteoblast proliferation and cell survival via Npnt gene expression

  5. we found that bone morphogenic protein-2 (BMP-2), known as an osteogenesis inducing cytokine, strongly up-regulated the expression of Npnt mRNA in a murine skeletal muscle cell line (C2C12) via the BMP-SMAD signaling pathway

  6. Nephronectin is capable of binding to heparan sulfate proteoglycans in basement membranes via the MAM domain.

  7. These results indicate that Npnt plays an important role in the initiation of hepatitis by recruiting CD4(+) T cells or NKT cells into the foci of inflammation.

  8. canonical TGF-b signaling through Smad2 regulates Npnt geneexpression in osteoblasts.

  9. expression of a fragment containing the 3'-untranslated region (3'-UTR) of nephronectin in osteoblast progenitor cells MC3T3-E1 promoted cell differentiation

  10. These results suggest that TNF-alpha inhibits POEM expression through the NF-kappaB signaling pathway and down-regulation of POEM influences the inhibition of osteoblast differentiation by TNF-alpha.

  11. TGF-beta inhibited differentiation of osteoblasts transfected with various truncated Npnt constructs, suggesting that TGF-beta can exert a down-stream effect on Npnt function.

  12. MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7

  13. it was demonstrated that nephronectin promotes differentiation during osteoblast differentiation and the EGF-like repeats were essential.

  14. results thus place nephronectin and alpha8beta1 integrin in a pathway that regulates Gdnf expression and is essential for kidney development

  15. deregulation of Nephronectin expression plays a role in the development or progression of malignant melanoma.

  16. These results indicate that the specific high-affinity binding of nephronectin to alpha8beta1 integrin is achieved by bipartite interaction of the integrin with the RGD motif and LFEIFEIER sequence.

Human Nephronectin (NPNT) interaction partners

  1. Biopsies from patients with focal segmental glomerulosclerosis and membranous nephropathy had increased miR-378a-3p expression and reduced glomerular levels of NPNT.

  2. Nephronectin (NPNT), a member of the epidermal growth factor (EGF) repeat superfamily proteins and a homologue of EGFL6, is expressed in osteoblasts. Intriguingly, the gene expression of NPNT is reduced in the bone of osteoporosis patients.

  3. The expression of nephronectin was sufficient to discriminate DN from other kidney diseases with mesangial matrix expansion and nodular lesions.

  4. Nephronectin is associated with the development of diabetic glomerulosclerosis.

  5. MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7

Nephronectin (NPNT) Protein Profile

Protein Summary

Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).

Gene names and symbols associated with Nephronectin Proteins (NPNT)

  • nephronectin (NPNT)
  • nephronectin (npnt)
  • nephronectin (Npnt)
  • 1110009H02Rik protein
  • AA682063 protein
  • AI314031 protein
  • EGFL6L protein
  • Nctn protein
  • POEM protein
  • si:ch211-202n8.2 protein

Protein level used designations for Nephronectin Proteins (NPNT)

nephronectin , nephronectin variant 1 , nephronectin variant 2 , nephronectin-like , preosteoblast EGF-like repeat protein with MAM domain

461420 Pan troglodytes
563273 Danio rerio
694470 Macaca mulatta
100101608 Oryctolagus cuniculus
100137096 Xenopus (Silurana) tropicalis
100405330 Callithrix jacchus
100469947 Ailuropoda melanoleuca
100544176 Meleagris gallopavo
100601218 Nomascus leucogenys
114249 Mus musculus
422535 Gallus gallus
255743 Homo sapiens
487891 Canis lupus familiaris
513362 Bos taurus
100172375 Pongo abelii
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