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Functional ligand of integrin alpha-8/beta-1 in kidney development. Additionally we are shipping Nephronectin Antibodies (42) and Nephronectin Kits (12) and many more products for this protein.
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In zebrafish miR-378a-3p mimic injection or npnt knockdown by a morpholino oligomer caused an identical to (show MYLIP Proteins)glomerular disease phenotype.
Morpholino-mediated knockdown of Npnt prevents proper heart valve leaflet formation and trabeculation and results in greater than 85% lethality at 7 days post-fertilization.
NPNT stimulates the phosphorylation of extracellular signal-regul (show EGF Proteins)ated kinase 1/2 (ERK1/2) and p38 mitogen-activated kin (show EGFL6 Proteins)ase (MAPK) in endothelial cells. NPNT is a paracrine angiogenic factor and may play a role in pathological osteoporosis.
These results suggest novel mechanisms for Wnt3a (show WNT3A Proteins)-induced osteoblast proliferation and cell survival via Npnt gene expression
we found that bone morphogenic protein-2 (BMP-2 (show BMP2 Proteins)), known as an osteogenesis inducing cytokine, strongly up-regulated the expression of Npnt mRNA in a murine skeletal muscle cell line (C2C12) via the BMP-SMAD (show SMAD1 Proteins) signaling pathway
Nephronectin is capable of binding to heparan sulfate proteoglycans in basement membranes via the MAM domain.
These results indicate that Npnt plays an important role in the initiation of hepatitis by recruiting CD4 (show CD4 Proteins)(+) T cells or NKT (show CTSL1 Proteins) cells into the foci of inflammation.
canonical TGF-b signaling through Smad2 (show SMAD2 Proteins) regulates Npnt geneexpression in osteoblasts.
expression of a fragment containing the 3'-untranslated region (3'-UTR) of nephronectin in osteoblast progenitor cells MC3T3-E1 promoted cell differentiation
These results suggest that TNF-alpha (show TNF Proteins) inhibits POEM expression through the NF-kappaB (show NFKB1 Proteins) signaling pathway and down-regulation of POEM influences the inhibition of osteoblast differentiation by TNF-alpha (show TNF Proteins).
TGF-beta (show TGFB1 Proteins) inhibited differentiation of osteoblasts transfected with various truncated Npnt constructs, suggesting that TGF-beta (show TGFB1 Proteins) can exert a down-stream effect on Npnt function.
MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7
Biopsies from patients with focal segmental glomerulosclerosis and membranous nephropathy had increased miR (show MLXIP Proteins)-378a-3p expression and reduced glomerular levels of NPNT.
Nephronectin (NPNT), a member of the epidermal growth factor (EGF (show EGF Proteins)) repeat superfamily proteins and a homologue of EGFL6 (show EGFL6 Proteins), is expressed in osteoblasts. Intriguingly, the gene expression of NPNT is reduced in the bone of osteoporosis patients.
The expression of nephronectin was sufficient to discriminate DN from other kidney diseases with mesangial matrix expansion and nodular lesions.
Nephronectin is associated with the development of diabetic glomerulosclerosis.
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).
, nephronectin variant 1
, nephronectin variant 2
, preosteoblast EGF-like repeat protein with MAM domain