anti-Neuronal PAS Domain Protein 4 (NPAS4) Antibodies

NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2\; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008].. Additionally we are shipping NPAS4 Proteins (6) and NPAS4 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NPAS4 225872 Q8BGD7
NPAS4 266734 Q8CJH6
NPAS4 266743 Q8IUM7
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Top anti-NPAS4 Antibodies at antibodies-online.com

Showing 10 out of 106 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  NPAS4  Sample Type:  Fetal Lung  Lane A:  Primary Antibody  Lane B:  Primary Antibody + Blocking Peptide  Primary Antibody Concentration:  1ug/ml  Peptide Concentration:  5ug/ml  Lysate Quantity:  25ug/lane/Lane  Gel Concentration:  0.12 WB Suggested Anti-NPAS4 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human Lung 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of NPAS4 staining in HEK293T cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of NPAS4 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$429.84
Details
Mouse Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using NPAS4 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$515.63
Details
Bat Goat Un-conjugated ELISA, WB 100 μg Log in to see 11 to 14 Days
$610.50
Details
Human Mouse FITC ICC, IF, IHC, WB Western Blot analysis of Rat Brain showing detection of ~90 kDa NPAS4 protein using Mouse Anti-NPAS4 Monoclonal Antibody, Clone S408-79 . Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 µg. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-NPAS4 Monoclonal Antibody  at 1:1000 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~90 kDa. Other Band(s): ~60, 45, 40, 38, 25, 20 kDa. 100 μg Log in to see 3 to 4 Days
$504.40
Details
Human Mouse PerCP ICC, IF, IHC, WB Western Blot analysis of Rat Brain showing detection of ~90 kDa NPAS4 protein using Mouse Anti-NPAS4 Monoclonal Antibody, Clone S408-79 . Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 µg. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-NPAS4 Monoclonal Antibody  at 1:1000 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~90 kDa. Other Band(s): ~60, 45, 40, 38, 25, 20 kDa. 100 μg Log in to see 3 to 4 Days
$513.50
Details
Human Mouse APC ICC, IF, IHC, WB Western Blot analysis of Rat Brain showing detection of ~90 kDa NPAS4 protein using Mouse Anti-NPAS4 Monoclonal Antibody, Clone S408-79 . Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 µg. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-NPAS4 Monoclonal Antibody  at 1:1000 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~90 kDa. Other Band(s): ~60, 45, 40, 38, 25, 20 kDa. 100 μg Log in to see 3 to 4 Days
$513.50
Details
Human Mouse Atto 565 ICC, IF, IHC, WB Western Blot analysis of Rat Brain showing detection of ~90 kDa NPAS4 protein using Mouse Anti-NPAS4 Monoclonal Antibody, Clone S408-79 . Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 µg. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-NPAS4 Monoclonal Antibody  at 1:1000 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~90 kDa. Other Band(s): ~60, 45, 40, 38, 25, 20 kDa. 100 μg Log in to see 3 to 4 Days
$514.80
Details

Top referenced anti-NPAS4 Antibodies

  1. Mouse (Murine) Polyclonal NPAS4 Primary Antibody for ICC, IF - ABIN4235495 : Wakasaya, Kawarabayashi, Watanabe, Yamamoto-Watanabe, Takamura, Kurata, Murakami, Abe, Yamada, Wakabayashi, Sasaki, Westaway, Hyslop, Matsubara, Shoji: Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy. in Journal of neuroscience research 2011 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal NPAS4 Primary Antibody for ELISA, WB - ABIN4340517 : Ooe, Saito, Mikami, Nakatuka, Kaneko: Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. in Molecular and cellular biology 2003 (PubMed)

  3. Cow (Bovine) Polyclonal NPAS4 Primary Antibody for WB - ABIN2779719 : Pruunsild, Sepp, Orav, Koppel, Timmusk: Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 (PubMed)
    Show all 2 Pubmed References

More Antibodies against NPAS4 Interaction Partners

Mouse (Murine) Neuronal PAS Domain Protein 4 (NPAS4) interaction partners

  1. the present results suggest that Npas4 controls neuronal homeostatic scaling during epileptogenesis through the induction of Homer1a as negative feedback machinery for the management of epilepsy

  2. NPAS4 is critical for the coordination of metabolism during the stimulation of electrically excitable cells; its loss leads to the defects in cellular metabolism that underlie the cellular dysfunction that occurs in metabolic disease.

  3. NPAS4 is an important regulator of plasticity mediated by endogenous cannabinoids.

  4. Results suggest that Npas4 mediates susceptibility to adolescent stress and subsequent cognitive functioning and inhibitory tone in adulthood. This shows a novel gene by environment interaction related to resilience vs vulnerability to stress, with implications for adolescent onset disorders like schizophrenia.

  5. ectopic expression of miR-744 and miR-224 during neural differentiation resulted in downregulation of endogenous Npas4 expression.

  6. Using a series of behavioral, molecular, pharmacological and genetic approaches in mice, study shows that deficiency in Npas4 affects adolescent expression of multiple markers of GABAergic transmission in the PFC, including parvalbumin and GAD67, in a sex-specific manner. Abnormal pattern of expression of GABAergic markers is associated with sex-specific and age-dependent cognitive and emotional impairments.

  7. The findings of this study suggest that Npas4 may be involved in post-stroke psychiatric changes related to anxiety ad sociability.

  8. NPAS4 is expressed in endothelial cells, regulates VE-cadherin expression and regulates sprouting angiogenesis.

  9. These findings suggest that 11beta-HSD1 may contribute to the decline in Npas4 and Arc mRNA levels associated with memory impairment during ageing

  10. beta cell cytotoxicity of the calcineurin inhibitor and immunosuppressant tacrolimus (FK-506) was prevented by Npas4 overexpression.

  11. Results suggest that transcription of the Npas4 gene is downregulated by stress through DNA methylation of its promoter

  12. induction of Npas4 identifies the area influenced by cortical spreading depression propagation.

  13. Cortex activation by sensory conditioning was found to upregulate the expression of both Npas4 and c-Fos.

  14. Data showed that differential levels of Npas4 expression in the brain may regulate anxiety, depression and cognition related disorders.

  15. Npas4 regulates Mdm2 expression during dendritic spine development in newborn olfactory bulb after sensory experience.

  16. we provide the first evidence that Npas4 is expressed during embryonic development and that it may have a developmental role that is unrelated to its function in the adult brain

  17. Study describes a transcriptional program that is induced by neuronal activity in inhibitory neurons; while neuronal activity induces expression of early-response transcription factors such as Npas4 in both excitatory and inhibitory neurons, Npas4 activates distinct programs of late-response genes in inhibitory and excitatory neurons.

  18. Our results reveal REST and microRNA dependent mechanisms that restrict NPAS4 expression to the brain

  19. sensory stimuli, by inducing NPAS4 and its target genes, differentially control spatial features of neuronal inhibition in a way that restricts the output of the neuron while creating a dendritic environment that is permissive for plasticity

  20. Npas4 is a key activity-dependent regulator that improves beta-cell efficiency in the face of stress.

Human Neuronal PAS Domain Protein 4 (NPAS4) interaction partners

  1. NPAS4 is expressed in endothelial cells, regulates VE-cadherin expression and regulates sprouting angiogenesis.

  2. This review summarizes the current knowledge of the roles that Npas4 may play in neuroinflammation and ischemia. [review]

  3. we provide the first evidence that Npas4 is expressed during embryonic development and that it may have a developmental role that is unrelated to its function in the adult brain

  4. These results provide insight into the mechanisms of NPAS4/ARNT dimerisation and transcriptional activation.

  5. a novel NXF signaling system on neural gene promoter may be a molecular target of the adverse effects of Sim2 in the mental retardation of Down's syndrome

Zebrafish Neuronal PAS Domain Protein 4 (NPAS4) interaction partners

  1. NPAS4 is expressed in endothelial cells, regulates VE-cadherin expression and regulates sprouting angiogenesis.

NPAS4 Antigen Profile

Protein Summary

NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2\; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004

Gene names and symbols associated with NPAS4

  • neuronal PAS domain protein 4 (Npas4) antibody
  • neuronal PAS domain protein 4 (NPAS4) antibody
  • neuronal PAS domain protein 4a (npas4a) antibody
  • neuronal PAS domain protein 4 (npas4) antibody
  • neuronal PAS domain-containing protein 4 (Tsp_02837) antibody
  • bHLHe79 antibody
  • Le-PAS antibody
  • MGC146621 antibody
  • npas4 antibody
  • NXF antibody
  • PASD10 antibody
  • wu:fj52d04 antibody
  • zgc:136764 antibody

Protein level used designations for NPAS4

HLH-PAS transcription factor NXF , bHLH-PAS type transcription factor NXF , limbic-enhanced PAS protein , neuronal PAS domain-containing protein 4 , neuronal PAS4 , bHLH PAS type transcription factor NXF , PAS domain-containing protein 10 , class E basic helix-loop-helix protein 79 , neuronal PAS domain protein 4 , neuronal PAS domain-containing protein 4-like

GENE ID SPECIES
225872 Mus musculus
266734 Rattus norvegicus
266743 Homo sapiens
466676 Pan troglodytes
483711 Canis lupus familiaris
714161 Macaca mulatta
724016 Danio rerio
780368 Xenopus (Silurana) tropicalis
781497 Bos taurus
10899621 Trichinella spiralis
100029618 Monodelphis domestica
100052469 Equus caballus
100359105 Oryctolagus cuniculus
100397060 Callithrix jacchus
100442686 Pongo abelii
100481488 Ailuropoda melanoleuca
100520174 Sus scrofa
100593820 Nomascus leucogenys
100715310 Cavia porcellus
101113970 Ovis aries
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