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NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2\; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008].. Additionally we are shipping NPAS4 Proteins (6) and NPAS4 Kits (4) and many more products for this protein.
Showing 10 out of 106 products:
Human Polyclonal NPAS4 Primary Antibody for ELISA, WB - ABIN4340517
Ooe, Saito, Mikami, Nakatuka, Kaneko: Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. in Molecular and cellular biology 2003
Cow (Bovine) Polyclonal NPAS4 Primary Antibody for WB - ABIN2779719
Pruunsild, Sepp, Orav, Koppel, Timmusk: Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Show all 2 Pubmed References
Mouse (Murine) Polyclonal NPAS4 Primary Antibody for ICC, IF - ABIN4235495
Wakasaya, Kawarabayashi, Watanabe, Yamamoto-Watanabe, Takamura, Kurata, Murakami, Abe, Yamada, Wakabayashi, Sasaki, Westaway, Hyslop, Matsubara, Shoji: Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy. in Journal of neuroscience research 2011
Results suggest that Npas4 mediates susceptibility to adolescent stress and subsequent cognitive functioning and inhibitory tone in adulthood. This shows a novel gene by environment interaction related to resilience vs vulnerability to stress, with implications for adolescent onset disorders like schizophrenia.
ectopic expression of miR (show MLXIP Antibodies)-744 and miR (show MLXIP Antibodies)-224 during neural differentiation resulted in downregulation of endogenous Npas4 expression.
Using a series of behavioral, molecular, pharmacological and genetic approaches in mice, study shows that deficiency in Npas4 affects adolescent expression of multiple markers of GABAergic transmission in the PFC (show CFP Antibodies), including parvalbumin (show PVALB Antibodies) and GAD67 (show GAD1 Antibodies), in a sex-specific manner. Abnormal pattern of expression of GABAergic markers is associated with sex-specific and age-dependent cognitive and emotional impairments.
The findings of this study suggest that Npas4 may be involved in post-stroke psychiatric changes related to anxiety ad sociability.
NPAS4 is expressed in endothelial cells, regulates VE-cadherin (show CDH5 Antibodies) expression and regulates sprouting angiogenesis.
These findings suggest that 11beta-HSD1 (show HSD11B1 Antibodies) may contribute to the decline in Npas4 and Arc (show NOL3 Antibodies) mRNA levels associated with memory impairment during ageing
beta cell cytotoxicity of the calcineurin inhibitor (show RCAN1 Antibodies) and immunosuppressant tacrolimus (FK-506) was prevented by Npas4 overexpression.
Results suggest that transcription of the Npas4 gene is downregulated by stress through DNA methylation (show HELLS Antibodies) of its promoter
induction of Npas4 identifies the area influenced by cortical spreading depression propagation.
Cortex activation by sensory conditioning was found to upregulate the expression of both Npas4 and c-Fos.
This review summarizes the current knowledge of the roles that Npas4 may play in neuroinflammation and ischemia. [review]
we provide the first evidence that Npas4 is expressed during embryonic development and that it may have a developmental role that is unrelated to its function in the adult brain
These results provide insight into the mechanisms of NPAS4/ARNT (show ARNT Antibodies) dimerisation and transcriptional activation.
a novel NXF signaling system on neural gene promoter may be a molecular target of the adverse effects of Sim2 (show SIM2 Antibodies) in the mental retardation of Down's syndrome
NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2\; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004
HLH-PAS transcription factor NXF
, bHLH-PAS type transcription factor NXF
, limbic-enhanced PAS protein
, neuronal PAS domain-containing protein 4
, neuronal PAS4
, bHLH PAS type transcription factor NXF
, PAS domain-containing protein 10
, class E basic helix-loop-helix protein 79
, neuronal PAS domain protein 4
, neuronal PAS domain-containing protein 4-like