NPAS4 antibody (AA 445-585)

Catalog No. ABIN7161390

Product Details anti-NPAS4 Antibody

Target: NPAS4 (Neuronal PAS Domain Protein 4 (NPAS4))

Binding Specificity: AA 445-585

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPAS4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Neuronal PAS domain-containing protein 4 protein (445-585AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NPAS4

Target: NPAS4 (Neuronal PAS Domain Protein 4 (NPAS4))

Alternative Name: NPAS4 (NPAS4 Products)

Synonyms: LE-PAS antibody, Nxf antibody, Le-PAS antibody, NXF antibody, PASD10 antibody, bHLHe79 antibody, npas4 antibody, wu:fj52d04 antibody, zgc:136764 antibody, MGC146621 antibody, neuronal PAS domain protein 4 antibody, neuronal PAS domain protein 4a antibody, neuronal PAS domain-containing protein 4 antibody, Npas4 antibody, NPAS4 antibody, npas4a antibody, npas4 antibody, Tsp_02837 antibody

Background:

Background: Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (By similarity). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed:14701734). Can activate the CME (CNS midline enhancer) element (PubMed:14701734).

Aliases: bHLH PAS type transcription factor NXF antibody, bHLHe79 antibody, Class E basic helix-loop-helix protein 79 antibody, HLH-PAS transcription factor NXF antibody, Le PAS antibody, limbic enhanced PAS protein antibody, neuronal PAS domain protein 4 antibody, Neuronal PAS domain-containing protein 4 antibody, Neuronal PAS4 antibody, NPAS4 antibody, NPAS4_HUMAN antibody, NXF antibody, PAS domain-containing protein 10 antibody, PASD10 antibody

UniProt: Q8IUM7