Nicotinamide Nucleotide Adenylyltransferase 2 Proteins (NMNAT2)

NMNAT2 product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Additionally we are shipping NMNAT2 Antibodies (42) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NMNAT2 23057 Q9BZQ4
NMNAT2 226518 Q8BNJ3
NMNAT2 289095 Q0HA29
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top NMNAT2 Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 2 to 3 Days
$435.00
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$547.80
Details
Baculovirus infected Insect Cells Human His tag 10 μg Log in to see 14 to 16 Days
$250.80
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 13 to 16 Days
$953.85
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 60 to 71 Days
$2,817.83
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,817.83
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,817.83
Details

NMNAT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2) Interaction Partners

Human Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2) interaction partners

  1. Six single-nucleotide polymorphisms (SNPs) in three loci were associated significantly with Kawasaki disease (KD) susceptibility, including the previously reported BLK locus. The other two loci were newly identified: NMNAT2 on chromosome 1q25.3 and the human leukocyte antigen (HLA) region on chromosome 6p21.3 (HLA-C, HLA-B, MICA and HCP5).

  2. analyses found that rs10494561, located in the intron region within NMNAT2, was associated with the severity of the prodromal symptoms of psychosis implicitly, mediated through the volume of the left hemisphere of the superior frontal region

  3. Data indicate a chaperone function of nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2), independent from its enzymatic activity, and NMNAT2 complexes with heat shock protein 90 (HSP90) to refold aggregated protein substrates.

  4. We confirmed association at NMNAT2 and identified independent SMG7 association with systemic lupus erythematosus in European American and Amerindian/Hispanic ancestries.

  5. NMNAT2 might participate in tumorigenesis of CRC.

  6. Knockdown of NMNAT-2 significantly reduces cellular NAD(+) levels and protects cells from p53-dependent cell death upon DNA damage, suggesting an important functional role of NMNAT-2 in p53-mediated signaling.

  7. Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) is essential for axon growth and survival.

  8. Overexpression of NMNAT2 in colorectal cancer cells renders them sensitive to Tiazofurin antineoplastic action.

  9. affects tau phosphorylation by regulating PP2A activity

  10. Decreased endogenous NMNAT2 function caused by reduced CREB signaling during pathological insults may be one of underlying mechanisms for neuronal death in tauopathies

  11. that overexpression of Nmnat2 in M-cells significantly delayed axon degeneration in vivo

  12. Nmnat2 is a neuronal protein peripherally attached to membranes via palmitoylation and suggest that Nmnat2 is transported to synaptic terminals via an endosomal pathway.

  13. analysis of isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases

  14. cloning, isolation and kinetics

  15. Nicotinamide 5'-mononucleotide adenylyltransferase-2 is markedly expressed in the islets of Langerhans.

  16. NMNAT1 is a nuclear protein, whereas NMNAT2 and -3 are localized to the Golgi complex and the mitochondria

  17. ATP binds before NMN with Golgi apparatus NMNAT2. NMNH conversion to NADH by NMNAT1 and NMNAT3 occurs at similar rates, conversion by NMNAT2 is much slower.

Mouse (Murine) Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2) interaction partners

  1. the deregulated expression of Nmnat2 appears to have a great influence on the cellular stress in the spinal cord of wobbler mice.

  2. Consistent with Skp1a functioning through regulation of Nmnat2, Skp1a knockdown fails to protect axons from Nmnat2 knockdown.

  3. Active nerve degeneration requires SARM1 and MAP kinases, including DLK, while the NAD+ synthetic enzyme NMNAT2 prevents degeneration.

  4. nicotinamide mononucleotide adenylyltransferase 2-depletion-dependent degeneration of established axons and restricted extension of developing axons are thus both SARM1 dependent

  5. Data indicate that thioesterases APT1/APT2 depalmitoylate nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) and zDHHC17 is the strongest candidate palmitoyltransferase for NMNAT2.

  6. Complete loss of Nmnat2 leads to a mature but distended bladder in utero and is not compatible with survival. Moderate loss of Nmnat2 has no effect on bladder development, survival, and has only modest effects on bladder function later in life.

  7. Together, our results establish Nmnat2 localisation and turnover as a valuable target for modulating axon degeneration in vivo.

  8. results suggest an essential role for NMNAT2 during axon growth

  9. Nmnat2 activity supports axon survival through a site of action distinct from Nmnat2 transport vesicles.

  10. Nmnat2 is involved in axon development or survival in a mammal.

  11. Decreased endogenous NMNAT2 function caused by reduced CREB signaling during pathological insults may be one of underlying mechanisms for neuronal death in tauopathies

  12. Nmnat2 is a neuronal protein peripherally attached to membranes via palmitoylation and suggest that Nmnat2 is transported to synaptic terminals via an endosomal pathway.

  13. The brain-specific Nmnat2 delays injury-induced axon degeneration dependent on its NAD synthesis activity. These findings provide new clues to further study the molecular mechanisms of axon degeneration and the related neurodegenerative diseases.

NMNAT2 Protein Profile

Protein Summary

This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed\; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NMNAT2

  • nicotinamide nucleotide adenylyltransferase 2 (nmnat2)
  • nicotinamide nucleotide adenylyltransferase 2 (NMNAT2)
  • nicotinamide nucleotide adenylyltransferase 2 (Nmnat2)
  • AI843915 protein
  • C1orf15 protein
  • D030041I09Rik protein
  • NMNAT2 protein
  • PNAT1 protein
  • PNAT2 protein
  • wu:fj59g01 protein
  • zgc:73048 protein

Protein level used designations for NMNAT2

NMN adenylyltransferase 2 , naMN adenylyltransferase 1 , nicotinamide mononucleotide adenylyltransferase 2 , nicotinate-nucleotide adenylyltransferase 1 , nicotinamide nucleotide adenylyltransferase 2 , NaMN adenylyltransferase 2 , nicotinate-nucleotide adenylyltransferase 2 , pyridine nucleotide adenylyltransferase 2

GENE ID SPECIES
336257 Danio rerio
610576 Canis lupus familiaris
743583 Pan troglodytes
771393 Gallus gallus
100124800 Xenopus (Silurana) tropicalis
100172391 Pongo abelii
23057 Homo sapiens
226518 Mus musculus
289095 Rattus norvegicus
511042 Bos taurus
Selected quality suppliers for NMNAT2 Proteins (NMNAT2)
Did you look for something else?