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Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Additionally we are shipping NMRK1 Antibodies (53) and NMRK1 Proteins (7) and many more products for this protein.
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nicotinamide riboside kinase 1 (NRK1) is necessary and rate-limiting for the use of exogenous nicotinamide riboside and nicotinamide mononucleotide for NAD(+) synthesis.
Crystal structure of NRK1 is reported.
NRK1 KO myotubes revealed redundancy in the NRK1/2 dependent metabolism of nicotinamide riboside to NAD+.
adenoviral delivery of NRK1 in diet- and age-induced mice elevates hepatic NAD(+) levels, reduces hepatic steatosis, and improves glucose tolerance and insulin sensitivity.
Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004
, RNK 1
, nicotinic acid riboside kinase 1
, nmR-K 1
, ribosylnicotinamide kinase 1
, ribosylnicotinic acid kinase 1
, nicotinamide riboside kinase 1