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NID2 encodes a member of the nidogen family of basement membrane proteins.
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Nidogen-2, a protein shown to be expressed intracellularly and for secretion by pre-adipocytes, was shown to interact, through its globular G3 domain, with TRAP 5a in vitro.
show that loss of nidogen 2, but not of nidogen 1 (show NID1 ELISA Kits), promotes lung metastasis of melanoma cells. Histological and ultrastructural analysis of nidogen 1 (show NID1 ELISA Kits)- and 2-deficient lungs did not reveal differences in morphology and ultrastructure of basement membrane
Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.
These findings revealed extensive coregulation of nidogen-1 (show NID1 ELISA Kits) and -2 expression and much more complementary functions of the two nidogens than previously recognized.
Nid2 is essential for late stages of lung development and for maintenance and/or integrity of cardiac tissue
nidogen-2 is equivalent to nidogen-1 (show NID1 ELISA Kits) in skin-organotypic coculture, and both can promote the development of a functional basement membrane zone
nidogen-1 (show NID1 ELISA Kits) and -2 have roles in development of the ectodermal basement membrane of the limb bud
decreased expression of the entactin-2 gene after treatment of the cells with ent-2-specific siRNA preparation led to reduced expression of the cell cycle inhibitor p21
The lack of nidogen-1 (show NID1 ELISA Kits), nidogen-2, or both nidogens, plays no crucial role in the occurrence and localization of laminin-111, collagen type IV (show COL4 ELISA Kits), and perlecan (show HSPG2 ELISA Kits) in murine tubular renal basement membranes.
In capillaries, basement membrane formation is severely impaired in the absence of nidogen-1 (show NID1 ELISA Kits) and -2, showing an irregular, patchy distribution and a dramatically reduced deposition of collagen IV (show COL4 ELISA Kits), perlecan (show HSPG2 ELISA Kits), and particularly laminin-411.
Addition of a TWIST1/NID2-based DNA methylation assay adds diagnostic value to urine cytology and the model is sensitive to the classification of equivocal cytology.
Promoter methylation of NID2 was significantly higher in nasopharyngeal carcinoma and esophageal squamous cell carcinoma cells. NID2 suppresses the EGFR (show EGFR ELISA Kits)/Akt (show AKT1 ELISA Kits) and integrin/FAK (show PTK2 ELISA Kits)/PLCgamma metastasis-related pathways.
Knockdown of nidogen-2 reduced SOX9 (show SOX9 ELISA Kits) expression, whereas it up-regulated RUNX2 (show RUNX2 ELISA Kits) expression
The cleavage of nidogen-1 (show NID1 ELISA Kits) and -2 is partially inhibited in human tumor samples.
combined methylation analysis of Twist homolog 1 (show TWIST1 ELISA Kits) and nidogen-2 genes may be a simple, noninvasive, sensitive, and specific method for detecting cancer cells in urine.
Decreased nidogen-2 expression is associated with hepatocellular carcinoma
NID2 promoter hypermethylation is associated with oral cavity squamous cell carcinoma.
Nidogen-2 is a new biomarker for ovarian cancer which correlates closely with CA125 (show MUC16 ELISA Kits).
short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1 (show NID1 ELISA Kits), fibulin-1 (show FBLN1 ELISA Kits) and fibulin-2 (show FBLN2 ELISA Kits)
Nidogen-2 compensation hypothesis to explain limited phenotype observed following elimination of nidogen-1 (show NID1 ELISA Kits) gene.
This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.