Nischarin Proteins (NISCH)

This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis\; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor.

• nischarin (NISCH)
• nischarin (Cyan7822_6841)
• nischarin S homeolog (nisch.S)
• nischarin (nisch)
• nischarin (Nisch)

• 1200007D05Rik protein
• 3202002H23Rik protein
• AW494485 protein
• hIRAS protein
• I-1 protein
• Show all synonym aliases
• IR1 protein
• IRAS protein
• NISCH protein

nischarin , nischarin-like , I1R , IR1 , imidazoline receptor 1 , imidazoline receptor I-1-like protein , imidazoline-1 receptor , I-1 receptor candidate protein , imidazoline receptor I-1 , I1R candidate protein , imidazoline receptor antisera selected