Nischarin Proteins
NISCH encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane.
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Nischarin (NISCH) (AA 2-1504) protein (His tag) Protein
Nischarin (NISCH) (AA 1-1593) protein (His tag) Protein
Nischarin (NISCH) (AA 1246-1346) protein (His tag,GST tag) Protein
Nischarin (NISCH) (AA 1246-1345) protein (GST tag) Protein
Nischarin (NISCH) (AA 1335-1435) protein (His tag,GST tag) Protein
Nischarin (NISCH) protein (Myc-DYKDDDDK Tag) Protein
Nischarin (NISCH) Protein Profile
Protein Summary
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis\; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor.
Gene names and symbols associated with Nischarin Proteins (NISCH)
- nischarin (NISCH) antibody
- nischarin (Cyan7822_6841) antibody
- nischarin S homeolog (nisch.S) antibody
- nischarin (nisch) antibody
- nischarin (Nisch) antibody
- 1200007D05Rik antibody
- 3202002H23Rik antibody
- AW494485 antibody
- hIRAS antibody
- I-1 antibody
- IR1 antibody
- IRAS antibody
- NISCH antibody
Protein level used designations for Nischarin Proteins (NISCH)
nischarin , nischarin-like , I1R , IR1 , imidazoline receptor 1 , imidazoline receptor I-1-like protein , imidazoline-1 receptor , I-1 receptor candidate protein , imidazoline receptor I-1 , I1R candidate protein , imidazoline receptor antisera selected
GENE ID | SPECIES |
---|---|
415893 | Gallus gallus |
476594 | Canis lupus familiaris |
515009 | Bos taurus |
745886 | Pan troglodytes |
9736308 | Cyanothece sp. PCC 7822 |
100036978 | Xenopus laevis |
100060179 | Equus caballus |
100156417 | Sus scrofa |
100170568 | Xenopus (Silurana) tropicalis |
100346537 | Oryctolagus cuniculus |
100391522 | Callithrix jacchus |
100457907 | Pongo abelii |
100540291 | Meleagris gallopavo |
100559383 | Anolis carolinensis |
100582208 | Nomascus leucogenys |
64652 | Mus musculus |
306255 | Rattus norvegicus |
11188 | Homo sapiens |
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