Nischarin Proteins (NISCH)

NISCH encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. Additionally we are shipping Nischarin Antibodies (26) and Nischarin Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NISCH 64652 Q80TM9
Rat NISCH NISCH 306255  
NISCH 11188 Q9Y2I1
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Top Nischarin Proteins at

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days

NISCH Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
Human , , ,
, , ,

More Proteins for Nischarin (NISCH) Interaction Partners

Mouse (Murine) Nischarin (NISCH) interaction partners

  1. results indicate that Nisch is an important AMPK inhibitor and a critical regulator of energy homeostasis, including lipid and glucose metabolism.

  2. We identified a significant genetic interaction between Nisch and Itga5; mice heterozygous for Itga5-null and homozygous for edison mutations display a significantly increased penetrance and severity of chronic otitis media.

  3. Nischarin inhibits neurite outgrowth by blocking PAK1 activation in neurons.

  4. Data from studies using various receptor antagonists/agonists suggest that imidazoline receptors (Nisch I-1), alpha2-adrenoceptors, and endothelin-A receptors are involved in body temperature regulation in mice.

  5. Activation of I1-imidazoline receptor ameliorated energy intake and epididymal white adipose tissue accumulation.

  6. Data suggest that both IR1 and IR2 (imidazoline receptor 2) play roles in acquisition of behavioral responses in alcoholism; activation of IR1 and IR2 may serve as molecular targets in prevention (and possibly treatment) of alcoholism.

  7. Activation of cerebral I(1)-imidazoline receptor decreased hyperphagia in streptozotocin-induced diabetic mice.

  8. Activation of I-1 R may activate FXR to lower plasma lipids, suggesting I-1 R as a new target for the treatment of hyperlipidemia.

  9. Report imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.

  10. guanidine increases glucose uptake via an activation of imidazoline I2 receptor through AMPK activation in skeletal muscle cell.

  11. Nisch regulates cell movement by inhibiting PAK.

  12. Data suggest that nischarin, in addition to regulating the p21-activated kinase (PAK) strand of Rac1 signaling, can also regulate other links in the web of Rac1 signaling pathways.

  13. Nischarin may serve as the functional I1-receptor

Human Nischarin (NISCH) interaction partners

  1. These experiments demonstrate an important role of Nischarin in regulating cell attachment, which adds to our understanding of the early events of the metastatic process in breast cancer.

  2. In the prefrontal cortex of long-term opiate/cocaine abusers, IRAS content was increased when compared to matched controls.

  3. IRAS is a new mu opioid receptor interacting protein that regulates agonist-induced trafficking of mu opioid receptor.

  4. The present data confirmed that Nishcharin might be a novel tumor suppressor and plays an important role in breast cancer cell apoptosis and metastasis, which can be used as a potential therapeutic target for breast cancer treatment.

  5. Data found that NISCH was significantly downregulated in ovarian neoplasm through its promotor silencing with hypermethylation and its expression was correlated with poor prognosis.

  6. Nischarin expression may therefore be used as a marker to predict the invasiveness and metastasis of primary breast cancer

  7. Tobacco smoke induces methylation changes in the NISCH gene promoter before any detectable cancer.

  8. unctional interaction between LKB1 and Nischarin to inhibit cell migration and breast tumor progression

  9. Imidazoline receptor 1 gene plays a role in the development of cardiac hypertrophy and ventirular remodeling.

  10. Nischarin reduces alpha5 integrin expression leading to reduction of FAK phosphorylation and Rac GTP loading, which in turn reduces tumor growth. NISCH also regulates PAK and LIMK signaling.

  11. Insulin receptor substrate 4 associates with the protein IRAS (IRAS protein)

  12. The heart possesses imidazoline I1-receptors that are up-regulated in the presence of hypertension or heart failure, which suggests their involvement in cardiovascular regulation.

  13. I(1)-receptors can abrogate the primary signaling cascade activated by NGF, most likely by increasing levels of a specific phosphatase to return dually phosphorylated ERK to its unphosphorylated state.

  14. hIRAS expression in PC12 cells resulted in protection against apoptosis

  15. Results suggest that IRAS may represent a previously unknown anti-apoptotic protein involved in the regulation of cell survival.

  16. Results describe three alternatively spliced transcripts of the human I(1)-imidazoline receptor candidate gene, IRAS.

  17. Results suggest that imidazoline-1 receptors (I(1)R) and alpha(2)-noradrenergic receptors (alpha(2)AR) may interact with each other.

  18. platelets lacked the 170-kD form of IRAS, but 33-kD and 85-kD bands were detectable and seemed to be possible fragments of full-length IRAS

  19. PX domain of imidazoline receptor antisera-selected protein(IRAS) is essential for association with phosphatidylinositol 3-phosphate-enriched endosomal membranes but is insufficient without coiled-coil domain

  20. The signaling pathway of IRAS in response to I1R agonists coupled with the activation of PC-PLC and its downstream signal transduction molecule, ERK. These findings are similar to those in the signaling pathways of native I1R.

Nischarin (NISCH) Protein Profile

Protein Summary

This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis\; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor.

Gene names and symbols associated with Nischarin Proteins (NISCH)

  • nischarin (NISCH)
  • nischarin (Cyan7822_6841)
  • nischarin S homeolog (nisch.S)
  • nischarin (nisch)
  • nischarin (Nisch)
  • 1200007D05Rik protein
  • 3202002H23Rik protein
  • AW494485 protein
  • hIRAS protein
  • I-1 protein
  • IR1 protein
  • IRAS protein
  • NISCH protein

Protein level used designations for Nischarin Proteins (NISCH)

nischarin , nischarin-like , I1R , IR1 , imidazoline receptor 1 , imidazoline receptor I-1-like protein , imidazoline-1 receptor , I-1 receptor candidate protein , imidazoline receptor I-1 , I1R candidate protein , imidazoline receptor antisera selected

415893 Gallus gallus
476594 Canis lupus familiaris
515009 Bos taurus
745886 Pan troglodytes
9736308 Cyanothece sp. PCC 7822
100036978 Xenopus laevis
100060179 Equus caballus
100156417 Sus scrofa
100170568 Xenopus (Silurana) tropicalis
100346537 Oryctolagus cuniculus
100391522 Callithrix jacchus
100457907 Pongo abelii
100540291 Meleagris gallopavo
100559383 Anolis carolinensis
100582208 Nomascus leucogenys
64652 Mus musculus
306255 Rattus norvegicus
11188 Homo sapiens
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