-
These experiments demonstrate an important role of Nischarin in regulating cell attachment, which adds to our understanding of the early events of the metastatic process in breast cancer.
-
In the prefrontal cortex of long-term opiate/cocaine abusers, IRAS content was increased when compared to matched controls.
-
IRAS is a new mu opioid receptor interacting protein that regulates agonist-induced trafficking of mu opioid receptor.
-
The present data confirmed that Nishcharin might be a novel tumor suppressor and plays an important role in breast cancer cell apoptosis and metastasis, which can be used as a potential therapeutic target for breast cancer treatment.
-
Data found that NISCH was significantly downregulated in ovarian neoplasm through its promotor silencing with hypermethylation and its expression was correlated with poor prognosis.
-
Nischarin expression may therefore be used as a marker to predict the invasiveness and metastasis of primary breast cancer
-
Tobacco smoke induces methylation changes in the NISCH gene promoter before any detectable cancer.
-
unctional interaction between LKB1 and Nischarin to inhibit cell migration and breast tumor progression
-
Imidazoline receptor 1 gene plays a role in the development of cardiac hypertrophy and ventirular remodeling.
-
Nischarin reduces alpha5 integrin expression leading to reduction of FAK phosphorylation and Rac GTP loading, which in turn reduces tumor growth. NISCH also regulates PAK and LIMK signaling.
-
Insulin receptor substrate 4 associates with the protein IRAS (IRAS protein)
-
The heart possesses imidazoline I1-receptors that are up-regulated in the presence of hypertension or heart failure, which suggests their involvement in cardiovascular regulation.
-
I(1)-receptors can abrogate the primary signaling cascade activated by NGF, most likely by increasing levels of a specific phosphatase to return dually phosphorylated ERK to its unphosphorylated state.
-
hIRAS expression in PC12 cells resulted in protection against apoptosis
-
Results suggest that IRAS may represent a previously unknown anti-apoptotic protein involved in the regulation of cell survival.
-
Results describe three alternatively spliced transcripts of the human I(1)-imidazoline receptor candidate gene, IRAS.
-
Results suggest that imidazoline-1 receptors (I(1)R) and alpha(2)-noradrenergic receptors (alpha(2)AR) may interact with each other.
-
platelets lacked the 170-kD form of IRAS, but 33-kD and 85-kD bands were detectable and seemed to be possible fragments of full-length IRAS
-
PX domain of imidazoline receptor antisera-selected protein(IRAS) is essential for association with phosphatidylinositol 3-phosphate-enriched endosomal membranes but is insufficient without coiled-coil domain
-
The signaling pathway of IRAS in response to I1R agonists coupled with the activation of PC-PLC and its downstream signal transduction molecule, ERK. These findings are similar to those in the signaling pathways of native I1R.
