Protein Summary

Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer (By similarity).

Gene names and symbols associated with NMRAL1

• NmrA like redox sensor 1 (NMRAL1) antibody
• NmrA-like family domain containing 1 (Nmral1) antibody
• NmrA like redox sensor 1 (Nmral1) antibody

• 1110025F24Rik antibody
• AI256624 antibody
• HSCARG antibody
• RGD1311451 antibody
• SDR48A1 antibody

Protein level used designations for NMRAL1

nmrA-like family domain-containing protein 1 , short chain dehydrogenase/reductase family 48A, member 1