Non-POU Domain Containing, Octamer-Binding Proteins (NONO)

NONO encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. Additionally we are shipping NONO Antibodies (132) and NONO Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NONO 4841 Q15233
NONO 317259 Q5FVM4
NONO 53610 Q99K48
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Top NONO Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,344.00
Details
Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$318.85
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

NONO Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus) ,

Mouse (Murine)

More Proteins for Non-POU Domain Containing, Octamer-Binding (NONO) Interaction Partners

Human Non-POU Domain Containing, Octamer-Binding (NONO) interaction partners

  1. Results show that NONO is upregulated in human esophageal squamous cell carcinoma (ESCC) tissue samples. Other findings suggest that NONO plays a potent role in multiple biological aspects of ESCC through activation of the Akt and Erk1/2 signaling pathways.

  2. we observed, for the first time, that the expression of p54 (show DDX6 Proteins) was markedly increased in the synovial tissues of rheumatoid arthritis patients.

  3. Findings reveal a new mechanism whereby HUR (show ELAVL1 Proteins) protects NONO from mir320-mediated degradation upon UVC exposure and identify a new component within the complex network of players underlying the DNA damage response adding mir320a to the list of p53 (show TP53 Proteins)-regulated targets upon genotoxic stress.

  4. GAPLINC has a role in promoting colorectal cancer invasion via binding to PSF/NONO and partly by stimulating the expression of SNAI2

  5. Here, it is reported that l-proline stabilizes purified NONO homodimers, enabling good-quality solution small-angle X-ray structure determination and crystallization. NONO crystallized in the apparent space group P21 (show CDKN1A Proteins) with a unique axis (b) of 408.9 A and with evidence of twinning, as indicated by the cumulative intensity distribution L statistic, suggesting the possibility of space group P1.

  6. Mechanistic dissection reveals that NEAT1 broadly interacts with the NONO-PSF (show IGFBP7 Proteins) heterodimer as well as many other RNA-binding proteins and that multiple RNA segments in NEAT1, including a 'pseudo pri-miRNA' near its 3' end, help attract the Drosha (show DROSHA Proteins)-DGCR8 (show DGCR8 Proteins) Microprocessor.

  7. The SFPQ*NONO complex contains an RNA binding domain, and prior work has demonstrated diverse roles in RNA metabolism. It is thus plausible that the additional repair function of NONO, revealed in cell-based assays, could involve RNA interaction.

  8. NEAT1-associated paraspeckle proteins P54nrb and PSF (show IGFBP7 Proteins) have been reported as positive regulators of c-Myc (show MYC Proteins) translation through interaction with c-Myc (show MYC Proteins) IRES

  9. Exome analysis identified a novel de novo splice-site variant c.1171+1G>T in exon 11 of NONO gene in a patient with intellectual disability and non-compaction cardiomyopathy.

  10. Case Report: melanotic PEComa of the sinonasal mucosa with NONO-TFE3 (show TFE3 Proteins) fusion.

Mouse (Murine) Non-POU Domain Containing, Octamer-Binding (NONO) interaction partners

  1. These findings argue that Nono collaborates with Erk (show EPHB2 Proteins) signaling to regulate the integrity of bivalent domains and Mouse embryonic stem cell pluripotency.

  2. NONO deficiency significantly compromises the response to ionizing radiation-induced DNA damage in the testes, consistent with cell type-specific loss of DSB repair capacity. The results provide evidence that this RNA binding protein significantly contributes to the DNA damage response in vivo.

  3. Data indicate involvement of non-POU domain-containing octamer-binding protein (NONO)/paraspeckle protein component 1 (PSPC1 (show PSPC1 Proteins))-aldehyde dehydrogenase 1 (NONO/PSPC1 (show PSPC1 Proteins)-ALDH1A1 (show ALDH1A1 Proteins)) in the modulation of Sertoli cells (SCs (show TWIST1 Proteins)) response to mono-(2-ethylhexyl) phthalate (MEHP) challenge.

  4. This study provides an improved understanding of the molecular basis (structure and dynamics) that governs the binding of the p54(nrb)/NonO RRM1 (show RRM1 Proteins) to one of its target RNAs.

  5. mechanisms have therapeutic implications for reducing beta-cell proliferation in insulinomas by inhibiting phospho-HLXB9 or its interaction with Nono and modulating the expression of its direct (Cblb) or indirect (c-Met) targets

  6. Cytoplasmic granule containing HERMES (show CD44 Proteins), NonO, PSF (show IL-3 Proteins), and G3BP1 (show G3BP1 Proteins) is a neuronal RNA-protein granule that is transported in neurites during retinal differentiation.

  7. Quantitative proteomics reveals dynamic interaction of JNK (show MAPK8 Proteins) with RNA transport granule proteins Sfpq and Nono during neuronal differentiation

  8. We analyzed the expression of sperm-specific Akap3 and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.

  9. NONO genetic insufficiency led to upregulation of PSPC1, which replaced NONO in a stable complex with SFPQ.

  10. Dsta indicate that NONO bound to p16-Ink4A cell cycle checkpoint gene and potentiated its circadian activation in a PER protein-dependent fashion.

NONO Protein Profile

Protein Summary

This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16.

Gene names and symbols associated with NONO

  • non-POU domain containing octamer binding (NONO)
  • non-POU domain containing, octamer-binding (NONO)
  • non-POU domain containing, octamer-binding (Nono)
  • non-POU domain containing, octamer binding L homeolog (nono.L)
  • non-POU-domain-containing, octamer binding protein (Nono)
  • AA407051 protein
  • AV149256 protein
  • nmt55 protein
  • nonA protein
  • nrb54 protein
  • P54 protein
  • p54nrb protein
  • xp54nrb protein

Protein level used designations for NONO

54 kDa nuclear RNA- and DNA-binding protein , 55 kDa nuclear protein , DNA-binding p52/p100 complex, 52 kDa subunit , non-POU domain-containing octamer (ATGCAAAT) binding protein , non-POU domain-containing octamer-binding protein , p54(nrb) , non-POU-domain-containing, octamer-binding protein , 54 kD nuclear RNA-binding protein

GENE ID SPECIES
4841 Homo sapiens
428701 Gallus gallus
612773 Canis lupus familiaris
615175 Bos taurus
317259 Rattus norvegicus
380427 Xenopus laevis
53610 Mus musculus
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