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NONO encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. Additionally we are shipping NONO Antibodies (132) and NONO Kits (6) and many more products for this protein.
Showing 7 out of 9 products:
Results show that NONO is upregulated in human esophageal squamous cell carcinoma (ESCC) tissue samples. Other findings suggest that NONO plays a potent role in multiple biological aspects of ESCC through activation of the Akt and Erk1/2 signaling pathways.
we observed, for the first time, that the expression of p54 (show DDX6 Proteins) was markedly increased in the synovial tissues of rheumatoid arthritis patients.
Findings reveal a new mechanism whereby HUR (show ELAVL1 Proteins) protects NONO from mir320-mediated degradation upon UVC exposure and identify a new component within the complex network of players underlying the DNA damage response adding mir320a to the list of p53 (show TP53 Proteins)-regulated targets upon genotoxic stress.
GAPLINC has a role in promoting colorectal cancer invasion via binding to PSF/NONO and partly by stimulating the expression of SNAI2
Here, it is reported that l-proline stabilizes purified NONO homodimers, enabling good-quality solution small-angle X-ray structure determination and crystallization. NONO crystallized in the apparent space group P21 (show CDKN1A Proteins) with a unique axis (b) of 408.9 A and with evidence of twinning, as indicated by the cumulative intensity distribution L statistic, suggesting the possibility of space group P1.
Mechanistic dissection reveals that NEAT1 broadly interacts with the NONO-PSF (show IGFBP7 Proteins) heterodimer as well as many other RNA-binding proteins and that multiple RNA segments in NEAT1, including a 'pseudo pri-miRNA' near its 3' end, help attract the Drosha (show DROSHA Proteins)-DGCR8 (show DGCR8 Proteins) Microprocessor.
The SFPQ*NONO complex contains an RNA binding domain, and prior work has demonstrated diverse roles in RNA metabolism. It is thus plausible that the additional repair function of NONO, revealed in cell-based assays, could involve RNA interaction.
NEAT1-associated paraspeckle proteins P54nrb and PSF (show IGFBP7 Proteins) have been reported as positive regulators of c-Myc (show MYC Proteins) translation through interaction with c-Myc (show MYC Proteins) IRES
Exome analysis identified a novel de novo splice-site variant c.1171+1G>T in exon 11 of NONO gene in a patient with intellectual disability and non-compaction cardiomyopathy.
Case Report: melanotic PEComa of the sinonasal mucosa with NONO-TFE3 (show TFE3 Proteins) fusion.
These findings argue that Nono collaborates with Erk (show EPHB2 Proteins) signaling to regulate the integrity of bivalent domains and Mouse embryonic stem cell pluripotency.
NONO deficiency significantly compromises the response to ionizing radiation-induced DNA damage in the testes, consistent with cell type-specific loss of DSB repair capacity. The results provide evidence that this RNA binding protein significantly contributes to the DNA damage response in vivo.
Data indicate involvement of non-POU domain-containing octamer-binding protein (NONO)/paraspeckle protein component 1 (PSPC1 (show PSPC1 Proteins))-aldehyde dehydrogenase 1 (NONO/PSPC1 (show PSPC1 Proteins)-ALDH1A1 (show ALDH1A1 Proteins)) in the modulation of Sertoli cells (SCs (show TWIST1 Proteins)) response to mono-(2-ethylhexyl) phthalate (MEHP) challenge.
This study provides an improved understanding of the molecular basis (structure and dynamics) that governs the binding of the p54(nrb)/NonO RRM1 (show RRM1 Proteins) to one of its target RNAs.
mechanisms have therapeutic implications for reducing beta-cell proliferation in insulinomas by inhibiting phospho-HLXB9 or its interaction with Nono and modulating the expression of its direct (Cblb) or indirect (c-Met) targets
Cytoplasmic granule containing HERMES (show CD44 Proteins), NonO, PSF (show IL-3 Proteins), and G3BP1 (show G3BP1 Proteins) is a neuronal RNA-protein granule that is transported in neurites during retinal differentiation.
Quantitative proteomics reveals dynamic interaction of JNK (show MAPK8 Proteins) with RNA transport granule proteins Sfpq and Nono during neuronal differentiation
We analyzed the expression of sperm-specific Akap3 and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.
NONO genetic insufficiency led to upregulation of PSPC1, which replaced NONO in a stable complex with SFPQ.
Dsta indicate that NONO bound to p16-Ink4A cell cycle checkpoint gene and potentiated its circadian activation in a PER protein-dependent fashion.
This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16.
54 kDa nuclear RNA- and DNA-binding protein
, 55 kDa nuclear protein
, DNA-binding p52/p100 complex, 52 kDa subunit
, non-POU domain-containing octamer (ATGCAAAT) binding protein
, non-POU domain-containing octamer-binding protein
, non-POU-domain-containing, octamer-binding protein
, 54 kD nuclear RNA-binding protein