anti-Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) Antibodies

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. Additionally we are shipping NUDT1 Proteins (15) and NUDT1 Kits (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NUDT1 4521 P36639
NUDT1 17766 P53368
NUDT1 117260 P53369
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-NUDT1 Antibodies at antibodies-online.com

Showing 10 out of 66 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (fro), IHC (p), SimWes, WB Simple Western: MTH1 Antibody [ABIN151036] - Simple Western lane view shows a specific band for MTH1 in 0.5 mg/ml of A431 lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. 0.2 mL Log in to see 7 to 9 Days
$514.63
Details
Human Rabbit Un-conjugated WB Western blot analysis of MTH1 expression in A549 (A), mouse liver (B), rat brain (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Mouse Un-conjugated ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (45.43 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$461.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB Immunohistochemistry-Paraffin: MTH1 Antibody  - Staining of human testis shows moderate cytoplasmic positivity in cells in seminiferous ducts. Immunocytochemistry/Immunofluorescence: MTH1 Antibody  - Staining of human cell line U-2 OS shows positivity in cytoplasm. Antibody staining is shown in green. 100 μL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Anti-NUDT1 / MTH1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1103348 dilution 1:100. Anti-NUDT1 / MTH1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100. 50 μL Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 16 Days
$334.02
Details
Human Rabbit Un-conjugated ICC, IF, IHC, WB 200 μL Log in to see 6 to 7 Days
$555.07
Details
Human Rabbit Un-conjugated IP, WB NUDT1 MaxPab rabbit polyclonal antibody. Western Blot analysis of NUDT1 expression in human kidney. Immunoprecipitation of NUDT1 transfected lysate using anti-NUDT1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with NUDT1 MaxPab mouse polyclonal antibody (B01) . 100 μL Log in to see 11 to 12 Days
$425.71
Details
Human Rabbit Un-conjugated ELISA, IHC, WB   100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Mouse Un-conjugated WB Western Blot analysis of NUDT1 expression in transfected 293T cell line by NUDT1 MaxPab polyclonal antibody.<br><br>Lane 1: NUDT1 transfected lysate(17.16 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μg Log in to see 11 to 12 Days
$440.00
Details

Top referenced anti-NUDT1 Antibodies

  1. Human Polyclonal NUDT1 Primary Antibody for ICC, IF - ABIN151036 : Takeshita, Ogawa, Asamoto, Shirai: Mechanistic approach of contrasting modifying effects of caffeine on carcinogenesis in the rat colon and mammary gland induced with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. in Cancer letters 2003 (PubMed)
    Show all 15 Pubmed References

  2. Polyclonal NUDT1 Primary Antibody for IHC (fro), WB - ABIN3073355 : Kennedy, Pass, Mitchell: Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue. in Free radical biology & medicine 2003 (PubMed)
    Show all 3 Pubmed References

More Antibodies against NUDT1 Interaction Partners

Human Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) interaction partners

  1. PRDX1 (show PRDX1 Antibodies) and MTH1 cooperate to prevent accumulation of oxidized guanine in the genome

  2. Results provide evidence that MTH1 is not essential for cancer cell survival.

  3. CDT1 (show CDT1 Antibodies), MCM7 (show MCM7 Antibodies), and NUDT1 were shown to be up-regulated in hepatocellular carcinoma tissues and provide a more accurate diagnosis than alpha-fetal protein alone.

  4. Our results reveal a novel antitumor mechanism of (S)-crizotinib in NSCLC which involves activation of ROS (show ROS1 Antibodies)-dependent ER stress apoptotic pathway and is independent of MTH1 inhibition

  5. this study showed that MTH1 protein expression was closely related to factors associated with a high malignant potential and poor patient survival

  6. method for predicting individual residue contributions to enzyme specificity and binding-site energies, and its application to MTH1.

  7. Data indicate the specificity of the enzyme 8-oxo-dGTPase MTH1 toward the substrate 8-oxo-dGTP.

  8. We demonstrate that in order to kill cancer cells MTH1 inhibitors must also introduce oxidized nucleotides into DNA. Furthermore, we describe TH1579 as a best-in-class MTH1 inhibitor, which we expect to be useful in order to further validate the MTH1 inhibitor concept.

  9. Data indicate a positive correlation of Skp2 and MTH1 expression in melanoma cell lines and patient specimens.

  10. Results show that MTH1 is overexpressed in esophageal squamous cell carcinoma, and suggestive of disease progression.

Mouse (Murine) Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) interaction partners

  1. The crystal structures of mouse MTH1 in complex with inhibitor TH588 and dog MTH1 elucidate the structural and sequence basis for the observed difference in their affinities for TH588. Amino acid residue 116 in MTH1 is an important determinant of TH588 affinity. The structure of mouse MTH1 in complex with the substrate 8-oxo-dGTP is presented.

  2. These results suggest that MTH1 deficiency might be a causative factor for aging and age-related disorders.

  3. MTH1 protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP.

  4. MTH1 efficiently suppresses the accumulation of 8-oxoG in both cellular DNA and RNA in the hippocampus, especially in microglia, caused by excitotoxicity.

NUDT1 Antigen Profile

Protein Summary

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Gene names and symbols associated with NUDT1

  • 7,8-dihydro-8-oxoguanine triphosphatase (mth1) antibody
  • 7,8-dihydro-8-oxoguanine triphosphatase (Tsp_07498) antibody
  • nudix hydrolase 1 (nudt1) antibody
  • 7,8-dihydro-8-oxoguanine triphosphatase (8odp) antibody
  • nudix hydrolase 1 (NUDT1) antibody
  • nudix (nucleoside diphosphate linked moiety X)-type motif 1 (Nudt1) antibody
  • nudix hydrolase 1 (Nudt1) antibody
  • Mth1 antibody
  • mutT antibody
  • nudT1 antibody

Protein level used designations for NUDT1

7,8-dihydro-8-oxoguanine triphosphatase , 2-hydroxy-dATP diphosphatase , 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase , 8-oxo-7,8-dihydroguanosine triphosphatase , 8-oxo-dGTPase , mutT human homolog 1 , nucleoside diphosphate-linked moiety X motif 1 , nucleoside diphosphate-linked moiety X-type motif 1 , nudix motif 1 , 8-oxo-7,8-dihydro-2'-dGTPase , mutT human homolog (8-oxo-dGTPase) , nudix-type motif 1

GENE ID SPECIES
8791327 Azospirillum sp. B510
10901982 Trichinella spiralis
100195837 Salmo salar
100305248 Oncorhynchus mykiss
4521 Homo sapiens
17766 Mus musculus
117260 Rattus norvegicus
Selected quality suppliers for anti-NUDT1 (NUDT1) Antibodies
Did you look for something else?