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anti-Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 (NUDT21) Antibodies

The protein encoded by NUDT21 is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. Additionally we are shipping Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 Proteins (12) and Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NUDT21 11051 O43809
NUDT21 68219 Q9CQF3
NUDT21 291877 Q4KM65
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Top anti-Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 Antibodies at antibodies-online.com

Showing 10 out of 48 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-NUDT21 Antibody Titration: 1.25ug/ml ELISA Titer: 1:312500 Positive Control: HepG2 cell lysate Rabbit Anti-NUDT21 Antibody Paraffin Embedded Tissue: Human Intestine Cellular Data: Epithelial cells of intestinal villas Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X 100 μL 2 to 3 Days
$229.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts from HepG2, using NUDT21 antibody. Lane 1 was treated with the blocking peptide. ABIN6273011 at 1/100 staining Human lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$390.77
Details
Human Mouse Un-conjugated ELISA, IF, IHC, IHC (p), WB 100 μg 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IF, IHC, IP, WB Western blot analysis of extracts of various cell lines, using NUDT21 antibody (ABIN1873983) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s. 100 μL 11 to 13 Days
$366.77
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to NUDT21 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml] Detection limit for recombinant GST tagged NUDT21 is approximately 3ng/ml as a capture antibody. 100 μg 11 to 12 Days
$440.00
Details
Dog Rabbit Un-conjugated IHC, ELISA, WB 100 μL 2 to 3 Days
$446.88
Details
Human Mouse Un-conjugated IHC, IHC (p), WB   100 μL 11 to 14 Days
$522.50
Details
Human Mouse Un-conjugated ICC, IF, IHC, IHC (p), WB   100 μL 11 to 14 Days
$522.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using NUDT21 antibody (ABIN5972537) at 1/1000 dilution. 100 μL 11 to 16 Days
$426.40
Details

More Antibodies against Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 Interaction Partners

Human Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 (NUDT21) interaction partners

  1. Pak1 expression is regulated by Nudt21.

  2. NUDT21 inhibits HCC proliferation, metastasis and tumorigenesis, at least in part, by suppressing PSMB2 and CXXC5.

  3. Findings suggest that CFIm25 plays an important role in lung cancer cell proliferation through regulating the alternative polyadenylation (APA) of oncogenes.

  4. RNA sequence preferences of unconventional RNA-binding proteins, Nudt21 and CNBP, has been described.

  5. Loss of NUDT21 shortened the 3'-UTR of various oncogenes in hepatocellular carcinoma cells. The shorter 3'-UTR contained less miRNA binding sites, which enabled the oncogenes to evade miRNA regulation and become overexpressed in HCC, leading to unregulated cancer cell proliferation.

  6. it was demonstrated that the CFIm25 protein was also downregulated in osteosarcoma tissues, and inhibited the proliferation and promoted the apoptosis of the cells. Elucidating the roles of miR181a and CFIm25 in osteosarcoma not only assists in further understanding the pathogenesis and progression of this disease, but also offers novel targets for effective therapies.

  7. The authors identify NUDT21 as a novel candidate for intellectual disability and neuropsychiatric disease, and elucidate a mechanism of pathogenesis by MeCP2 dysregulation via altered alternative polyadenylation.

  8. Crystal structure of CFIm25-CFIm68 RRM heterotetramer illustrated that CFIm25 homodimer is clamped by two CFIm68 monomers on each side of the dimer interface.

  9. Data provide evidence that CFIm exists as a heterotetramer of 25-kD, 59-kD and 68-kD subunits of CFIm: CFIm25, CFIm59 and CFIm68.

  10. crystal structures of the CFI(m)25 homodimer in complex with UGUAAA and UUGUAU RNA sequences

  11. region in the subunit of CF I(m) involved in RNA binding, protein-protein interactions, and subcellular localization

  12. Evidence that CFIm25 regulates alternative poly(A) site selection of genes with tandem poly(A) signals in their 3'-UTRs.

  13. Results from crystallographic and biochemical experiments suggest that CF I(m)25 makes use of its Nudix fold to bind but not hydrolyze ATP and diadenosine tetraphosphate.

  14. The crystal structure of human CPSF5 was solved at 1.9 A resolution.

Mouse (Murine) Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 (NUDT21) interaction partners

  1. Nudt21 directs differential polyadenylation of over 1,500 transcripts in cells acquiring pluripotency, although only a fraction changed protein levels. These proteins were strongly enriched for chromatin regulators.

  2. Here we report that the CFIm subunits NUDT21/CPSF5 and CPSF6 are highly enriched in mouse male germ cells relative to somatic cells.

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 (NUDT21) Antigen Profile

Protein Summary

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides.

Gene names and symbols associated with NUDT21

  • nudix hydrolase 21 (NUDT21) antibody
  • nudix (nucleoside diphosphate linked moiety X)-type motif 21 (Nudt21) antibody
  • nudix hydrolase 21 (Nudt21) antibody
  • nudix hydrolase 21 (nudt21) antibody
  • nudix hydrolase 21 L homeolog (nudt21.L) antibody
  • cleavage and polyadenylation specificity factor subunit 5 (ANI_1_1518144) antibody
  • cleavage and polyadenylation specificity factor subunit 5 (AOR_1_2312154) antibody
  • cleavage and polyadenylation specificity factor subunit 5 (PTRG_11035) antibody
  • cleavage and polyadenylation specificity factor subunit 5 (PAAG_04662) antibody
  • cleavage and polyadenylation specificity factor subunit 5 (MCYG_02022) antibody
  • cleavage and polyadenylation specificity factor subunit 5 (VDBG_06706) antibody
  • cleavage and polyadenylation specificity factor subunit 5 (MGYG_04057) antibody
  • cleavage and polyadenylation specific factor 5 (cpsf5) antibody
  • autocrine motility factor receptor (PGTG_05353) antibody
  • cleavage and polyadenylation specificity factor subunit 5 (Tsp_03672) antibody
  • cleavage and polyadenylation specific factor 5 (LOC732888) antibody
  • cleavage and polyadenylation specific factor 5 (AFUA_5G02030) antibody
  • cleavage and polyadenylation specific factor 5 (NFIA_040090) antibody
  • cleavage and polyadenylation specific factor 5 (ACLA_003240) antibody
  • cleavage and polyadenylation specific factor 5 (CC1G_07993) antibody
  • cleavage and polyadenylation specific factor 5 (PMAA_039710) antibody
  • cleavage and polyadenylation specific factor 5 (AFLA_025180) antibody
  • cleavage and polyadenylation specific factor 5 (TSTA_079060) antibody
  • cleavage and polyadenylation specific factor 5 (BDBG_01565) antibody
  • cleavage and polyadenylation specific factor 5 (TERG_04393) antibody
  • nudix hydrolase homolog 21 (NUDT21) antibody
  • 25kDa antibody
  • 3110048P04Rik antibody
  • 5730530J16Rik antibody
  • Afu5g02030 antibody
  • An16g01870 antibody
  • AO090003001316 antibody
  • atnudt21 antibody
  • AU014860 antibody
  • AW549947 antibody
  • CFIM25 antibody
  • cpsf5 antibody
  • nudix hydrolase homolog 21 antibody
  • T9L24.30 antibody
  • T9L24_30 antibody
  • zgc:63966 antibody

Protein level used designations for NUDT21

CPSF 25 kDa subunit , cleavage and polyadenylation specific factor 5, 25 kD subunit , cleavage and polyadenylation specific factor 5, 25 kDa , cleavage and polyadenylation specificity factor 25 kDa subunit , cleavage and polyadenylation specificity factor subunit 5 , cleavage factor Im complex 25 kDa subunit , nucleoside diphosphate-linked moiety X motif 21 , nudix motif 21 , pre-mRNA cleavage factor Im (25kD) , pre-mRNA cleavage factor Im 25 kDa subunit , pre-mRNA cleavage factor Im, 25kD subunit , cleavage and polyadenylation specific factor 5 , Cleavage and polyadenylation specificity factor 5 , cleavage and polyadenylation specificity factor subunit 5-like

GENE ID SPECIES
11051 Homo sapiens
68219 Mus musculus
291877 Rattus norvegicus
394092 Danio rerio
444830 Xenopus laevis
4988580 Aspergillus niger CBS 513.88
5992362 Aspergillus oryzae RIB40
6349347 Pyrenophora tritici-repentis Pt-1C-BFP
9096568 Paracoccidioides sp. 'lutzii' Pb01
9229141 Arthroderma otae CBS 113480
9537188 Verticillium alfalfae VaMs.102
10029169 Arthroderma gypseum CBS 118893
100172645 Pongo abelii
100301863 Oncorhynchus mykiss
100528826 Ictalurus punctatus
10534307 Puccinia graminis f. sp. tritici CRL 75-36-700-3
10910141 Trichinella spiralis
732888 Bombyx mori
3505522 Aspergillus fumigatus Af293
4593152 Neosartorya fischeri NRRL 181
4708488 Aspergillus clavatus NRRL 1
6014831 Coprinopsis cinerea okayama7130
7028602 Talaromyces marneffei ATCC 18224
7909208 Aspergillus flavus NRRL3357
8102520 Talaromyces stipitatus ATCC 10500
8507179 Ajellomyces dermatitidis SLH14081
10379768 Trichophyton rubrum CBS 118892
518859 Bos taurus
478123 Canis lupus familiaris
843688 Arabidopsis thaliana
100858636 Gallus gallus
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