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The product of OTUB1 is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. Additionally we are shipping OTU Domain, Ubiquitin Aldehyde Binding 1 Proteins (18) and many more products for this protein.
Showing 10 out of 129 products:
Human Monoclonal OTUB1 Primary Antibody for ELISA, WB - ABIN527583
Edelmann, Kramer, Altun, Kessler: Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion. in The FEBS journal 2010
Mouse (Murine) Polyclonal OTUB1 Primary Antibody for ELISA, WB - ABIN451694
Juris, Shah, Shokat, Dixon, Vacratsis: Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry. in FEBS letters 2006
Silencing of OTU domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) inhibits migration of human glioma cells in vitro. Study results suggested that OTUB1 was a valuable marker in the pathogenesis of human gliomas and could be used as a novel biomarker for glioma therapy in the future.
Data suggest that inhibiting OTUB1-FOXM1 (show FOXM1 Antibodies) interaction is a potential avenue for ovarian cancer therapy.
Data indicate that knockdown of otubain 1 protein (Otub1) reduced the levels of double minute 4 protein (MDMX (show MDM4 Antibodies)).
High expression of NUDC is associated with prostate cancer.
OTUB1 may play an important role in colon cancer development and metastasis.
the upregulation of miR (show MLXIP Antibodies)-194 affects the hNUDC expression, leading to a downregulated expression of Mpl (show MPL Antibodies)/ERK (show EPHB2 Antibodies) pathway proteins, and suppresses the mitosis and proliferation of NSCLC cells.
An increase of OTUB1 expression is commonly observed in non-small-cell lung carcinomas harboring wild-type KRAS and is associated with increased levels of ERK1/2 phosphorylation, high Ki67 (show MKI67 Antibodies) score, and poorer patient survival.
NudC is co-localized with Aurora B (show AURKB Antibodies) at the midbody and co-immunoprecipitated with Aurora B (show AURKB Antibodies) in mitosis. results suggest that that dynamic phosphorylation of NudC by Aurora B (show AURKB Antibodies) regulates cytokinesis.
the data suggest that OTUB1 limits the ubiquitination and degradation of FOXM1 (show FOXM1 Antibodies) in breast cancer and has a key role in genotoxic agent resistance.
substrate for hydroxylation by FIH (show CASR Antibodies) on N22
GRAIL (show RNF128 Antibodies) expression is regulated by the IL2 (show IL2 Antibodies)/mTOR (show FRAP1 Antibodies)/Otubain-1 axis in CD4 (show CD4 Antibodies) T cells during Trypanosoma cruzi infection.
Otub1 as a Tau deubiquitinase in vitro and in vivo, involved in formation of pathological Tau forms, including small soluble oligomeric forms
OTUB1 localizes predominantly in the nucleus and is highly expressed in the brain, liver, spleen, lung, kidney, large intestine, small intestine, stomach, ovary, uterus and thym (show PTMA Antibodies)
This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2.
OTU domain-containing ubiquitin aldehyde-binding protein 1
, OTU-domain Ubal-binding 1
, deubiquitinating enzyme OTUB1
, ubiquitin thioesterase OTUB1
, ubiquitin-specific protease otubain 1
, ubiquitin-specific-processing protease OTUB1
, nuclear distribution C homolog
, nuclear distribution gene C homolog
, nuclear distribution protein C homolog
, nuclear migration protein nudC
, otubain 1
, OTU domain, ubiquitin aldehyde binding 1
, Ubiquitin thioesterase OTUB1
, ubiquitin thioesterase otub1