anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) Antibodies

OTUB1 encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. Additionally we are shipping OTU Domain, Ubiquitin Aldehyde Binding 1 Proteins (17) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
OTUB1 55611 Q96FW1
OTUB1 107260 Q7TQI3
OTUB1 293705 B2RYG6
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Top anti-OTU Domain, Ubiquitin Aldehyde Binding 1 Antibodies at antibodies-online.com

Showing 10 out of 142 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-OTUB1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-OTUB1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Goat Un-conjugated ELISA, WB ABIN302152 (0.05µg/ml) staining of Mouse Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Mouse Un-conjugated IF, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Mouse Un-conjugated FACS, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$522.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis OTUB1 using HuvEc whole cell lysates ABIN6279907 staining  Hela cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL Log in to see 11 to 12 Days
$390.77
Details
Cow Goat Un-conjugated EIA, WB   0.1 mg Log in to see 4 to 8 Days
$462.00
Details
Human Rabbit Un-conjugated ICC, IF, WB WB Image Sample (50 ug of whole cell lysate) A: Mouse liver 12% SDS PAGE antibody diluted at 1:500 ICC/IF Image Immunofluorescence analysis of methanol-fixed HeLa, using OTUB1, antibody at 1:50 dilution. 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Porcine Brain Tissue ; Lane2: Human HeLa Cells. Figure. Western Blot; Sample: Recombinant OTUB1, Human. 100 μg Log in to see 15 to 18 Days
$386.00
Details

Top referenced anti-OTU Domain, Ubiquitin Aldehyde Binding 1 Antibodies

  1. Mouse (Murine) Polyclonal OTUB1 Primary Antibody for ELISA, WB - ABIN451694 : Juris, Shah, Shokat, Dixon, Vacratsis: Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry. in FEBS letters 2006 (PubMed)

  2. Human Monoclonal OTUB1 Primary Antibody for ELISA, WB - ABIN527583 : Edelmann, Kramer, Altun, Kessler: Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion. in The FEBS journal 2010 (PubMed)

More Antibodies against OTU Domain, Ubiquitin Aldehyde Binding 1 Interaction Partners

Human OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) interaction partners

  1. findings reveal a mechanism that stabilizes the mTORC1 inhibitor DEPTOR via OTUB1's deubiquitinase activity.

  2. High OTUB1 expression is associated with esophageal squamous cell carcinoma metastasis through modulating Snail stability.

  3. Overexpression of OTUB1 (OTU domain-containing ubiquitin aldehyde binding protein 1) in hepatocellular carcinoma (HCC) could be a supplementary biomarker for HCC because it plays a vital role in the progression of HCC.

  4. Silencing of OTU domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) inhibits migration of human glioma cells in vitro. Study results suggested that OTUB1 was a valuable marker in the pathogenesis of human gliomas and could be used as a novel biomarker for glioma therapy in the future.

  5. Data suggest that inhibiting OTUB1-FOXM1 interaction is a potential avenue for ovarian cancer therapy.

  6. Data indicate that knockdown of otubain 1 protein (Otub1) reduced the levels of double minute 4 protein (MDMX).

  7. OTUB1 may play an important role in colon cancer development and metastasis.

  8. An increase of OTUB1 expression is commonly observed in non-small-cell lung carcinomas harboring wild-type KRAS and is associated with increased levels of ERK1/2 phosphorylation, high Ki67 score, and poorer patient survival.

  9. the data suggest that OTUB1 limits the ubiquitination and degradation of FOXM1 in breast cancer and has a key role in genotoxic agent resistance.

  10. substrate for hydroxylation by FIH on N22

  11. Data show that casein kinase 2 (CK2)-mediated phosphorylation of deubiquitylating enzyme OTUB1 at Ser16 causes nuclear accumulation of OTUB1.

  12. OTUB1 promoted the metastasis of CRC cell lines.

  13. After viral infection, HSCARG interacted with tumor necrosis receptor-associated factor 3 (TRAF3) and inhibited its ubiquitination by promoting the recruitment of OTUB1 to TRAF3.

  14. These data reveal novel insights into the Otub1 inhibition of E2 wherein monoubiquitination promotes the interaction of Otub1 with UbcH5 and the function to suppress it.

  15. OTUB1 enhances TGF-beta signaling by inhibiting the ubiquitylation and degradation of active SMAD2 and SMAD3.

  16. A second role of OTUB1-E2 interactions is to stimulate OTUB1 cleavage of Lys48 polyubiquitin. This stimulation is regulated by the ratio of charged to uncharged E2 and by the concentration of Lys48-linked polyubiquitin and free ubiquitin.

  17. These results suggest that OTUB1 regulates NF-kappaB and MAPK signalling pathways and TNF-dependent cell death by modulating c-IAP1 stability.

  18. the crystal structure of human OTUB1 in complex with human UBC13 and MMS2

  19. structural and biochemical studies elucidating how OTUB1 inhibits UBC13 and other E2 enzymes

  20. OTUB1 therefore co-opts Lys48-linked ubiquitin chain recognition to suppress ubiquitin conjugation and the DNA damage response

Mouse (Murine) OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) interaction partners

  1. High OTUB1 expression is associated with esophageal squamous cell carcinoma metastasis through modulating Snail stability.

  2. GRAIL expression is regulated by the IL2/mTOR/Otubain-1 axis in CD4 T cells during Trypanosoma cruzi infection.

  3. Otub1 as a Tau deubiquitinase in vitro and in vivo, involved in formation of pathological Tau forms, including small soluble oligomeric forms

Pig (Porcine) OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) interaction partners

  1. OTUB1 localizes predominantly in the nucleus and is highly expressed in the brain, liver, spleen, lung, kidney, large intestine, small intestine, stomach, ovary, uterus and thym

OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) Antigen Profile

Protein Summary

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with OTUB1

  • OTU deubiquitinase, ubiquitin aldehyde binding 1 (OTUB1) antibody
  • OTU domain, ubiquitin aldehyde binding 1 (Otub1) antibody
  • OTU deubiquitinase, ubiquitin aldehyde binding 1 (Otub1) antibody
  • OTU deubiquitinase, ubiquitin aldehyde binding 1b (otub1b) antibody
  • OTU deubiquitinase, ubiquitin aldehyde binding 1 L homeolog (otub1.L) antibody
  • OTU domain, ubiquitin aldehyde binding 1 (otub1) antibody
  • OTU domain, ubiquitin aldehyde binding 1 (OTUB1) antibody
  • AI850305 antibody
  • fa19h07 antibody
  • MGC131231 antibody
  • OTB1 antibody
  • OTU1 antibody
  • otub1 antibody
  • wu:fa19h07 antibody
  • zgc:92839 antibody

Protein level used designations for OTUB1

OTU domain-containing ubiquitin aldehyde-binding protein 1 , OTU-domain Ubal-binding 1 , deubiquitinating enzyme OTUB1 , otubain-1 , ubiquitin thioesterase OTUB1 , ubiquitin-specific protease otubain 1 , ubiquitin-specific-processing protease OTUB1 , otubain 1 , OTU domain, ubiquitin aldehyde binding 1 , Ubiquitin thioesterase OTUB1 , ubiquitin thioesterase otub1

GENE ID SPECIES
55611 Homo sapiens
107260 Mus musculus
293705 Rattus norvegicus
436773 Danio rerio
540984 Bos taurus
717989 Macaca mulatta
734823 Xenopus laevis
742797 Pan troglodytes
100286700 Salmo salar
100302092 Sus scrofa
100529028 Ictalurus punctatus
611228 Canis lupus familiaris
100714472 Cavia porcellus
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