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OTUD5 encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. Additionally we are shipping OTUD5 Proteins (5) and many more products for this protein.
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Human Polyclonal OTUD5 Primary Antibody for ELISA - ABIN451675
Kayagaki, Phung, Chan, Chaudhari, Quan, ORourke, Eby, Pietras, Cheng, Bazan, Zhang, Arnott, Dixit: DUBA: a deubiquitinase that regulates type I interferon production. in Science (New York, N.Y.) 2007
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.
OTU domain containing 5
, OTU domain-containing protein 5
, OTU domain-containing protein 5-A
, deubiquitinating enzyme A
, deubiquinating enzyme A