anti-Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) Antibodies

OLIG2 encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. Additionally we are shipping OLIG2 Proteins (7) and OLIG2 Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
OLIG2 10215 Q13516
OLIG2 304103  
OLIG2 50913 Q9EQW6
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Top anti-OLIG2 Antibodies at antibodies-online.com

Showing 10 out of 129 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Dog Rabbit Un-conjugated IHC, WB WB Suggested Anti-OLIG2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate Sample Type: Human Optic Nerve and Spinal CordCellular Target: Oligoden Drocyte Lineage CellsDilution: 1:500 100 μL 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated IHC, WB Sample Type: Human Optic Nerve and Spinal CordCellular Target: Oligoden Drocyte Lineage CellsDilution: 1:500 100 μL 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated IHC, WB WB Suggested Anti-OLIG2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Jurkat cell lysate Sample Type: Human Optic Nerve and Spinal CordCellular Target: Oligoden Drocyte Lineage CellsDilution: 1:500 100 μL 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated IF, IHC (fro), IP, WB   0.1 mL 4 to 8 Days
$511.50
Details
Human Mouse Un-conjugated ELISA, IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
$551.83
Details
Human Mouse Un-conjugated ICC, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Immunofluorescence analysis of U251 cells using OLIG2 mouse mAb (green) . Blue: DRAQ5 fluorescent DNA dye. 100 μL 3 to 4 Days
$430.10
Details
Human Rabbit Un-conjugated ELISA, IHC, IP, WB   100 μg 1 to 2 Days
$462.69
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with OLIG2 antibody ABIN214131 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-OLIG2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Ot ... 100 μL 11 to 14 Days
$727.83
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Mouse Un-conjugated ELISA, IHC, IHC (p), WB Human Brain, Oligodendroglia: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-OLIG2 antibody IHC of human brain, oligodendroglia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
$561.00
Details

Top referenced anti-OLIG2 Antibodies

  1. Human Polyclonal OLIG2 Primary Antibody for ICC, IF - ABIN447418 : Kolenda-Roberts, Harris, Singletary, Hardisty: Immunohistochemical characterization of spontaneous and acrylonitrile-induced brain tumors in the rat. in Toxicologic pathology 2012 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal OLIG2 Primary Antibody for IF, IHC (fro) - ABIN5551609 : Norwood, Franklin, Sharma, DMello: Histone deacetylase 3 is necessary for proper brain development. in The Journal of biological chemistry 2014 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal OLIG2 Primary Antibody for ICC, IHC - ABIN969331 : Bonnet-Dupeyron, Combes, Boespflug-Tanguy, Vaurs-Barrière: Absence of OLIG2 mutations in patients presenting with a severe Pelizaeus-Merzbacher-like leukodystrophy associated with motor neuron dysfunction. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal OLIG2 Primary Antibody for IF, IHC (p) - ABIN523613 : Libard, Popova, Amini, Kärjä, Pietiläinen, Hämäläinen, Sundström, Hesselager, Bergqvist, Ekman, Zetterling, Smits, Nilsson, Pfeifer, de Ståhl, Enblad, Ponten, Alafuzoff: Human cytomegalovirus tegument protein pp65 is detected in all intra- and extra-axial brain tumours independent of the tumour type or grade. in PLoS ONE 2014 (PubMed)

  5. Dog (Canine) Polyclonal OLIG2 Primary Antibody for IHC, WB - ABIN2777565 : Mitkus, Hyde, Vakkalanka, Kolachana, Weinberger, Kleinman, Lipska: Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia. in Schizophrenia research 2007 (PubMed)
    Show all 2 Pubmed References

  6. Dog (Canine) Polyclonal OLIG2 Primary Antibody for IHC, WB - ABIN2777314 : Cowen, Green: The Kallmann's syndrome variant (KSV) model of the schizophrenias. in Schizophrenia research 1993 (PubMed)
    Show all 2 Pubmed References

  7. Dog (Canine) Polyclonal OLIG2 Primary Antibody for IHC, WB - ABIN2777566 : Sun, Hafler, Kaing, Kitada, Ligon, Widlund, Yuk, Stiles, Rowitch: Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. in Developmental biology 2006 (PubMed)

More Antibodies against OLIG2 Interaction Partners

Human Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) interaction partners

  1. Results show that Olig2(+) oligodendrocyte precursor-like glioma cells invade by single-cell vessel co-option and preserve the blood-brain barrier (BBB). Conversely, Olig2-negative glioma cells form dense perivascular collections and promote angiogenesis and BBB breakdown, leading to innate immune cell activation. Olig2 was found to regulate Wnt7b expression in a p53-dependent manner.

  2. indicate Olig2 as an onco-requisite factor in diffuse intrinsic pontine glioma

  3. OLIG2 immunoreactivity was observed in GABAergic cells of the proliferative zones of the MGE and septum, but not necessarily co-expressed with NKX2.1, and OLIG2 expression was also extensively seen in the LGE, CGE, and cortex

  4. Data suggest positive feedback loops including oligodendrocyte transcription factor 2 (OLIG2): loops of epigenetic regulation.

  5. Data show that oligodendrocyte transcription factor 2 (OLIG2) is epigenetically regulated via DNA methylation and expressed in a subset of AML patients.

  6. Ectopic expression of phosphomimetic Olig2 is sufficient to block TGF-beta2-mediated invasion.

  7. phosphorylation of the motif itself serves as a template to prime phosphorylation of additional serines and creates a highly charged "acid blob" in the amino terminus of Olig2.

  8. Olig2 was expressed in cord blood eosinophils on d 24, when cord blood eosinophils are considered fully differentiated, but no earlier. It was also expressed in human peripheral-blood eosinophils but not neutrophils, monocytes, lymphocytes, or cord blood mast cells. Many genes, including eosinophil surface molecules, were up-regulated along with OLIG2. OLIG2 shRNA or siRNA downregulated SIGLEC-8 mRNA and protein.

  9. Data indicate that transcription factors Sox10 and Olig2 play key roles in oligodendrocytes (OLs) specification.

  10. Olig2 expressions were successfully detected in 12 (15.58%) of 77 SVZ type II Glioblastomas (GBs) and 16 (21.3%) of 75 SVZ type III GBs.

  11. Olig2 was positive in 5 out of 44 ependymomas (11%) and 50 out of 54 (93%) non-ependymal tumors

  12. The present study is the first to verify the associations of SNPs rs762178, rs1059004, and rs9653711 of the OLIG2 gene with OCD in a Chinese Han population. Thus, OLIG2 might serve as a potential target for OCD treatment

  13. The results demonstrate that the expression of Olig2 in dental pulp stem cells reduces the expression of stem cell markers and induces the development of oligodendrocyte progenitors.

  14. High Olig2 expression is associated with oligodendrogliomas.

  15. OLIG2 is the most specific GSC marker.

  16. Our study suggests that CGT expression is controlled by balanced expression of the negative modulator OLIG2 and positive regulator Nkx2.2, providing new insights into how expression of GalCer is tightly regulated in cell-type- and stage-specific manners.

  17. Authors investigated the role of Pten in these two critical cellular compartments in adult and developing brains using methods for activation or suppression of PI3K signaling in glial and neuronal progenitors expressing Olig2.

  18. LGR5 expression may be functionally correlated with the neurogenic competence, and be regulated by OLIG2 in stem-like cells in glioblastoma.

  19. We found that the risk allele OLIG2 (A) was associated with reduced white matter integrity in the corona radiata bilaterally

  20. Olig2-positive cells in glioneuronal tumors, and some of them also exhibited neuronal features

Zebrafish Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) interaction partners

  1. these data raise the possibility that cells expressing olig2 are intermediate targets that help guide facial motor neuron migration.

  2. Study detected at least five different classes of olig2-positive cells in the telencephalon of the adult zebrafish.

  3. By cooperating with Shh, FGF-receptor signalling controls the expression of olig2, a patterning gene essential for the specification of somatic motoneurons and oligodendrocytes.

  4. Loss of olig2 function prevents primary motor neuron and oligodendrocyte development, whereas olig2 overexpression promotes formation of excess primary motor neurons and oligodendrocytes.

  5. Olig2 is required for repression of iro3 expression in the progenitor domain of ventral spinal cord

  6. data indicate that Hedgehog & Wnt work in opposition across the dorsoventral axis of the cerebellum to regulate formation of olig2(+) neurons; we propose that Hedgehog limits the range of Wnt signaling, which is necessary for olig2(+) neuron development

  7. commitment of basal diencephalic DA neurons is regulated by the combined action of the neural protein Olig2 and its downstream neuronal specific effector Sim1

Mouse (Murine) Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) interaction partners

  1. postnatal deletion of Olig2 caused NG2 cells in the neocortex but not in other gray matter regions to become protoplasmic astrocytes. However, NG2 cells in the neocortex became more resistant to astrocyte fate switch over the first 3 postnatal weeks.

  2. findings reveal a tight coupling between the regulatory networks that control patterning and neuronal differentiation and demonstrate how Olig2 acts as the developmental pacemaker coordinating the spatial and temporal pattern of motor neuron generation

  3. Cuprizone-induced schizophrenia-like symptoms involved olig2 upregulation. The silence of olig2 could prevent changes, likely through regulating MBP, CNPase, and GFAP expressions.

  4. transient hypoxia at P7 altered the expression of Olig1 and Nkx2.2, resulting in delayed myelination in the external capsule.

  5. Functionally, deletion of Olig2 alone results in a preferential reduction of Purkinje cells in the cerebellum, which is likely mediated by decreased neuronal generation from their cerebellar ventricular zone progenitors.

  6. Olig2 is down-regulated in oligodendrocyte progenitor cells infected by Theiler's murine encephalomyelitis virus.

  7. phosphorylation of the motif itself serves as a template to prime phosphorylation of additional serines and creates a highly charged "acid blob" in the amino terminus of Olig2.

  8. OLIG2 modulates growth factor signaling in two distinct populations of glioma stem cells, characterized by expression of either the epidermal growth factor receptor (EGFR) or platelet-derived growth factor receptor alpha.

  9. the dynamic interplay between HMGNs and H1 in chromatin epigenetically regulates the expression of OLIG1&2, thereby affecting oligodendrocyte development and myelination, and mouse behavior.

  10. Olig2 was significantly upregulated and transcriptionally targeted the Gpr17 locus

  11. Brg1 represses Olig2 expression and the specification of oligodendrocyte progenitors, but is required for OPC differentiation and oligodendrocyte maturation

  12. Data show that oligodendrocyte transcription factor 2 (Olig2) deletion causes platelet-derived growth factor receptor (PDGFR) downregulation and reciprocal epidermal growth factor receptor (EGFR) upregulation.

  13. This study suggests that Olig2 misexpression in neural stem cells elicits neurogenesis defects and neuronal cell death, which may contribute to developmental disorders including Down syndrome

  14. OLIG2 is a multifunctional regulator of neural stem cell self-renewal

  15. Olig2 expression is localized to the cochleovestibular ganglia from E12.5 through E14.5

  16. Olig2 overexpression accelerates the differentiation of mouse embryonic stem cells into oligodendrocyte progenitor cells in vitro.

  17. This study demonstrated that that OLIG2 overexpression in oligodendrocyte progenitor cells might be a possible therapeutic mechanism for enhancing myelin repair.

  18. Results from expression pattern suggests that Olig2 may have an important role in the early stage of Purkinje cell development.

  19. Prox1 controls binary fate decisions between motor neurons and V2 interneurons in progenitor cells via direct repression of Olig2 gene regulatory elements

  20. Phosphorylated Olig2 is preferentially localized to a transcriptionally active compartment for regulation of gene expression.

OLIG2 Antigen Profile

Protein Summary

This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14\;21)(q11.2\;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.

Gene names and symbols associated with OLIG2

  • oligodendrocyte transcription factor 4 (olig4) antibody
  • oligodendrocyte transcription factor 2 (OLIG2) antibody
  • oligodendrocyte transcription factor 2 (Olig2) antibody
  • oligodendrocyte lineage transcription factor 2 (olig2) antibody
  • oligodendrocyte lineage transcription factor 2 (OLIG2) antibody
  • AI604895 antibody
  • Bhlhb1 antibody
  • bHLHe19 antibody
  • MGC89336 antibody
  • Olg-2 antibody
  • OLIG2 antibody
  • olig3.2 antibody
  • Oligo2 antibody
  • PRKCBP2 antibody
  • RACK17 antibody
  • RK17 antibody
  • wu:fc64g09 antibody

Protein level used designations for OLIG2

oligodendrocyte transcription factor 4 , oligodendrocyte transcription factor 3 , oligodendrocyte lineage transcription factor 2 , basic domain, helix-loop-helix protein, class B, 1 , class B basic helix-loop-helix protein 1 , class E basic helix-loop-helix protein 19 , human protein kinase C-binding protein RACK17 , oligodendrocyte transcription factor 2 , oligodendrocyte-specific bHLH transcription factor 2 , protein kinase C-binding protein 2 , bHLH transcription factor Olig2 , oligo2

GENE ID SPECIES
734024 Xenopus (Silurana) tropicalis
749928 Pan troglodytes
100137242 Papio anubis
100347256 Oryctolagus cuniculus
10215 Homo sapiens
539695 Bos taurus
304103 Rattus norvegicus
325288 Danio rerio
50913 Mus musculus
428612 Gallus gallus
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