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OLIG2 encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. Additionally we are shipping OLIG2 Kits (7) and OLIG2 Proteins (7) and many more products for this protein.
Showing 10 out of 124 products:
Human Polyclonal OLIG2 Primary Antibody for ICC, IF - ABIN447418
Kolenda-Roberts, Harris, Singletary, Hardisty: Immunohistochemical characterization of spontaneous and acrylonitrile-induced brain tumors in the rat. in Toxicologic pathology 2012
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Human Monoclonal OLIG2 Primary Antibody for ICC, IHC - ABIN969331
Bonnet-Dupeyron, Combes, Boespflug-Tanguy, Vaurs-Barrière: Absence of OLIG2 mutations in patients presenting with a severe Pelizaeus-Merzbacher-like leukodystrophy associated with motor neuron dysfunction. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008
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Human Monoclonal OLIG2 Primary Antibody for IF, IHC (p) - ABIN523613
Libard, Popova, Amini, Kärjä, Pietiläinen, Hämäläinen, Sundström, Hesselager, Bergqvist, Ekman, Zetterling, Smits, Nilsson, Pfeifer, de Ståhl, Enblad, Ponten, Alafuzoff: Human cytomegalovirus tegument protein pp65 is detected in all intra- and extra-axial brain tumours independent of the tumour type or grade. in PLoS ONE 2014
Dog (Canine) Polyclonal OLIG2 Primary Antibody for IHC, WB - ABIN2777314
Mitkus, Hyde, Vakkalanka, Kolachana, Weinberger, Kleinman, Lipska: Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia. in Schizophrenia research 2007
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Dog (Canine) Polyclonal OLIG2 Primary Antibody for IHC, WB - ABIN2777565
Cowen, Green: The Kallmann's syndrome variant (KSV) model of the schizophrenias. in Schizophrenia research 1993
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Dog (Canine) Polyclonal OLIG2 Primary Antibody for IHC, WB - ABIN2777566
Sun, Hafler, Kaing, Kitada, Ligon, Widlund, Yuk, Stiles, Rowitch: Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. in Developmental biology 2006
indicate Olig2 as an onco-requisite factor in diffuse intrinsic pontine glioma
OLIG2 immunoreactivity was observed in GABAergic cells of the proliferative zones of the MGE and septum, but not necessarily co-expressed with NKX2.1 (show NKX2-1 Antibodies), and OLIG2 expression was also extensively seen in the LGE, CGE, and cortex
Data suggest positive feedback loops including oligodendrocyte transcription factor 2 (OLIG2): loops of epigenetic regulation.
Data show that oligodendrocyte transcription factor 2 (OLIG2) is epigenetically regulated via DNA methylation (show HELLS Antibodies) and expressed in a subset of AML (show RUNX1 Antibodies) patients.
Ectopic expression of phosphomimetic Olig2 is sufficient to block TGF-beta2 (show TGFB2 Antibodies)-mediated invasion.
phosphorylation of the motif itself serves as a template to prime phosphorylation of additional serines and creates a highly charged "acid blob" in the amino terminus of Olig2.
Olig2 was expressed in cord blood eosinophils on d 24, when cord blood eosinophils are considered fully differentiated, but no earlier. It was also expressed in human peripheral-blood eosinophils but not neutrophils, monocytes, lymphocytes, or cord blood mast cells. Many genes, including eosinophil surface molecules, were up-regulated along with OLIG2. OLIG2 shRNA or siRNA downregulated SIGLEC-8 (show SIGLEC8 Antibodies) mRNA and protein.
Data indicate that transcription factors Sox10 (show SOX10 Antibodies) and Olig2 play key roles in oligodendrocytes (OLs) specification.
Olig2 expressions were successfully detected in 12 (15.58%) of 77 SVZ type II Glioblastomas (GBs (show GNB5 Antibodies)) and 16 (21.3%) of 75 SVZ type III GBs (show GNB5 Antibodies).
Olig2 was positive in 5 out of 44 ependymomas (11%) and 50 out of 54 (93%) non-ependymal tumors
these data raise the possibility that cells expressing olig2 are intermediate targets that help guide facial motor neuron migration.
Study detected at least five different classes of olig2-positive cells in the telencephalon of the adult zebrafish.
By cooperating with Shh (show SHH Antibodies), FGF-receptor (show FGFR2 Antibodies) signalling controls the expression of olig2, a patterning gene essential for the specification of somatic motoneurons and oligodendrocytes.
Loss of olig2 function prevents primary motor neuron and oligodendrocyte development, whereas olig2 overexpression promotes formation of excess primary motor neurons and oligodendrocytes.
Olig2 is required for repression of iro3 (show IRX3 Antibodies) expression in the progenitor domain of ventral spinal cord
data indicate that Hedgehog (show SHH Antibodies) & Wnt (show WNT2 Antibodies) work in opposition across the dorsoventral axis of the cerebellum to regulate formation of olig2(+) neurons; we propose that Hedgehog (show SHH Antibodies) limits the range of Wnt (show WNT2 Antibodies) signaling, which is necessary for olig2(+) neuron development
commitment of basal diencephalic DA neurons is regulated by the combined action of the neural protein Olig2 and its downstream neuronal specific effector Sim1
Cuprizone-induced schizophrenia-like symptoms involved olig2 upregulation. The silence of olig2 could prevent changes, likely through regulating MBP (show MBP Antibodies), CNPase (show CNP Antibodies), and GFAP (show GFAP Antibodies) expressions.
transient hypoxia at P7 altered the expression of Olig1 (show OLIG1 Antibodies) and Nkx2.2 (show Nkx2-2 Antibodies), resulting in delayed myelination in the external capsule.
Functionally, deletion of Olig2 alone results in a preferential reduction of Purkinje cells in the cerebellum, which is likely mediated by decreased neuronal generation from their cerebellar ventricular zone progenitors.
Olig2 is down-regulated in oligodendrocyte progenitor cells infected by Theiler's murine encephalomyelitis virus.
OLIG2 modulates growth factor signaling in two distinct populations of glioma stem cells, characterized by expression of either the epidermal growth factor receptor (EGFR (show EGFR Antibodies)) or platelet-derived growth factor receptor alpha (show PDGFRA Antibodies).
the dynamic interplay between HMGNs and H1 in chromatin epigenetically regulates the expression of OLIG1 (show OLIG1 Antibodies)&2, thereby affecting oligodendrocyte development and myelination, and mouse behavior.
Olig2 was significantly upregulated and transcriptionally targeted the Gpr17 (show GPR17 Antibodies) locus
Brg1 (show SMARCA4 Antibodies) represses Olig2 expression and the specification of oligodendrocyte progenitors, but is required for OPC differentiation and oligodendrocyte maturation
Data show that oligodendrocyte transcription factor 2 (Olig2) deletion causes platelet-derived growth factor receptor (PDGFR (show PDGFRB Antibodies)) downregulation and reciprocal epidermal growth factor receptor (EGFR (show EGFR Antibodies)) upregulation.
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14\;21)(q11.2\;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.
oligodendrocyte transcription factor 4
, oligodendrocyte transcription factor 3
, oligodendrocyte lineage transcription factor 2
, basic domain, helix-loop-helix protein, class B, 1
, class B basic helix-loop-helix protein 1
, class E basic helix-loop-helix protein 19
, human protein kinase C-binding protein RACK17
, oligodendrocyte transcription factor 2
, oligodendrocyte-specific bHLH transcription factor 2
, protein kinase C-binding protein 2
, bHLH transcription factor Olig2