anti-Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) Antibodies

Human Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) interaction partners

1. indicate Olig2 as an onco-requisite factor in diffuse intrinsic pontine glioma

2. OLIG2 immunoreactivity was observed in GABAergic cells of the proliferative zones of the MGE and septum, but not necessarily co-expressed with NKX2.1 (show NKX2-1 Antibodies), and OLIG2 expression was also extensively seen in the LGE, CGE, and cortex

3. Data suggest positive feedback loops including oligodendrocyte transcription factor 2 (OLIG2): loops of epigenetic regulation.

4. Data show that oligodendrocyte transcription factor 2 (OLIG2) is epigenetically regulated via DNA methylation (show HELLS Antibodies) and expressed in a subset of AML (show RUNX1 Antibodies) patients.

5. Ectopic expression of phosphomimetic Olig2 is sufficient to block TGF-beta2 (show TGFB2 Antibodies)-mediated invasion.

6. phosphorylation of the motif itself serves as a template to prime phosphorylation of additional serines and creates a highly charged "acid blob" in the amino terminus of Olig2.

7. Olig2 was expressed in cord blood eosinophils on d 24, when cord blood eosinophils are considered fully differentiated, but no earlier. It was also expressed in human peripheral-blood eosinophils but not neutrophils, monocytes, lymphocytes, or cord blood mast cells. Many genes, including eosinophil surface molecules, were up-regulated along with OLIG2. OLIG2 shRNA or siRNA downregulated SIGLEC-8 (show SIGLEC8 Antibodies) mRNA and protein.

8. Data indicate that transcription factors Sox10 (show SOX10 Antibodies) and Olig2 play key roles in oligodendrocytes (OLs) specification.

9. Olig2 expressions were successfully detected in 12 (15.58%) of 77 SVZ type II Glioblastomas (GBs (show GNB5 Antibodies)) and 16 (21.3%) of 75 SVZ type III GBs (show GNB5 Antibodies).

10. Olig2 was positive in 5 out of 44 ependymomas (11%) and 50 out of 54 (93%) non-ependymal tumors

Zebrafish Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) interaction partners

1. these data raise the possibility that cells expressing olig2 are intermediate targets that help guide facial motor neuron migration.

2. Study detected at least five different classes of olig2-positive cells in the telencephalon of the adult zebrafish.

3. By cooperating with Shh (show SHH Antibodies), FGF-receptor (show FGFR2 Antibodies) signalling controls the expression of olig2, a patterning gene essential for the specification of somatic motoneurons and oligodendrocytes.

4. Loss of olig2 function prevents primary motor neuron and oligodendrocyte development, whereas olig2 overexpression promotes formation of excess primary motor neurons and oligodendrocytes.

5. Olig2 is required for repression of iro3 (show IRX3 Antibodies) expression in the progenitor domain of ventral spinal cord

6. data indicate that Hedgehog (show SHH Antibodies) & Wnt (show WNT2 Antibodies) work in opposition across the dorsoventral axis of the cerebellum to regulate formation of olig2(+) neurons; we propose that Hedgehog (show SHH Antibodies) limits the range of Wnt (show WNT2 Antibodies) signaling, which is necessary for olig2(+) neuron development

7. commitment of basal diencephalic DA neurons is regulated by the combined action of the neural protein Olig2 and its downstream neuronal specific effector Sim1

Mouse (Murine) Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) interaction partners

1. Cuprizone-induced schizophrenia-like symptoms involved olig2 upregulation. The silence of olig2 could prevent changes, likely through regulating MBP (show MBP Antibodies), CNPase (show CNP Antibodies), and GFAP (show GFAP Antibodies) expressions.

2. transient hypoxia at P7 altered the expression of Olig1 (show OLIG1 Antibodies) and Nkx2.2 (show Nkx2-2 Antibodies), resulting in delayed myelination in the external capsule.

3. Functionally, deletion of Olig2 alone results in a preferential reduction of Purkinje cells in the cerebellum, which is likely mediated by decreased neuronal generation from their cerebellar ventricular zone progenitors.

4. Olig2 is down-regulated in oligodendrocyte progenitor cells infected by Theiler's murine encephalomyelitis virus.

5. phosphorylation of the motif itself serves as a template to prime phosphorylation of additional serines and creates a highly charged "acid blob" in the amino terminus of Olig2.

6. OLIG2 modulates growth factor signaling in two distinct populations of glioma stem cells, characterized by expression of either the epidermal growth factor receptor (EGFR (show EGFR Antibodies)) or platelet-derived growth factor receptor alpha (show PDGFRA Antibodies).

7. the dynamic interplay between HMGNs and H1 in chromatin epigenetically regulates the expression of OLIG1 (show OLIG1 Antibodies)&2, thereby affecting oligodendrocyte development and myelination, and mouse behavior.

8. Olig2 was significantly upregulated and transcriptionally targeted the Gpr17 (show GPR17 Antibodies) locus

9. Brg1 (show SMARCA4 Antibodies) represses Olig2 expression and the specification of oligodendrocyte progenitors, but is required for OPC differentiation and oligodendrocyte maturation

10. Data show that oligodendrocyte transcription factor 2 (Olig2) deletion causes platelet-derived growth factor receptor (PDGFR (show PDGFRB Antibodies)) downregulation and reciprocal epidermal growth factor receptor (EGFR (show EGFR Antibodies)) upregulation.