Osteoclast Associated Receptor Proteins (OSCAR)

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. Additionally we are shipping OSCAR Antibodies (41) and OSCAR Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
OSCAR 232790 Q8VBT3
OSCAR 126014 Q8IYS5
Rat OSCAR OSCAR 292537  
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Top OSCAR Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
$5,262.31
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human His tag 100 μg 13 to 16 Days
$553.85
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
Baculovirus infected Insect Cells Human His tag   50 μg 13 to 16 Days
$646.15
Details
Escherichia coli (E. coli) Human Un-conjugated   1 mg 11 to 18 Days
$1,762.47
Details

OSCAR Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
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Human , , , ,
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More Proteins for Osteoclast Associated Receptor (OSCAR) Interaction Partners

Mouse (Murine) Osteoclast Associated Receptor (OSCAR) interaction partners

  1. OSCAR expression in monocytic cells is regulated by proatherogenic stimuli further pointing towards a role in vascular inflammation or plaque vulnerability during atherosclerosis

  2. Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice.

  3. PU.1 and MITF transcription factors synergistically activate OSCAR gene expression, which is further enhanced by the TRANCE-induced MKK6/p38 signaling cascade.

  4. the FcRgamma-mediated signal transduction by OSCAR is involved in osteoclast differentiation

  5. OSCAR but not TREM-2 is involved in the positive feedback loop of the immunoreceptor-NFATc1 pathway during osteoclastogenesis

  6. analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts

  7. The overexpression of PIAS3 attenuates osteoclast formation and down-regulates the expression of NFATc1 and osteoclast-associated receptor (OSCAR), which are important modulators in osteoclastogenesis.

  8. Results indicate that USFs 1 and 2 serve as modulators in the induction of OSCAR and RANKL-mediated osteoclastogenesis.

Human Osteoclast Associated Receptor (OSCAR) interaction partners

  1. regulation of OSCAR by TNF-alpha and receptor activator of NF kappa beta ligand (RANKL) in pre-osteoclasts/osteoclasts

  2. OSCAR can play a proinflammatory role in monocyte-derived cells and may contribute crucially on multiple levels to rheumatoid arthritis pathogenesis.

  3. Each domain of OSCAR binds a collagen triple-helical peptide; the primary site is on the C-terminal domain in contrast to GPVI and LAIR-1.

  4. OSCAR is a receptor for surfactant protein D that activates TNF-alpha release from human CCR2+ inflammatory monocytes.

  5. Data indicate that osteoclast associated receptor (OSCAR) was strongly expressed by the vasculature of active rheumatoid arthritis (RA) patients.

  6. Plasma OSCAR level was higher in the serum of RA patients than controls, and higher in patients with destructive RA rather than non-destructive RA.

  7. Rotative stress in mouse cells results in increased levels of Oscar transcription.

  8. endothelial cell-derived OSCAR was found to be involved in the STAT signaling pathway and to affect monocyte adhesion.

  9. OSCAR is expressed in vascular endothelial cells and is regulated by oxLDL involving NFATc1

  10. Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice.

  11. This review discusses the structure-function relationship, expression pattern, and physiological role of OSCAR in osteoimmunology and summarizes its potential implications for human diseases.

  12. hOSCAR thus represents a novel class of molecule expressed by dendritic cells involved in the initiation of the immune response.

  13. ligation of OSCAR promotes dendritic cell survival by an ERK- and PI3K-dependent pathway, linked to expression of the Bcl-2 and Bcl-x(L) antiapoptotic molecules

  14. Human OSCAR mediates the rescue from apoptosis and the cooperation between dendritic cells and antigen-specific T cells that is prevented by CD85j receptor.

  15. Promoter variant in OSCAR gene (OSCAR-2322A>G) might be one of genetic determinants of bone density in postmenopausal women.

  16. analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts

  17. OSCAR is a functional receptor on monocytes and neutrophils, involved in the induction of the primary proinflammatory cascade and the initiation of downstream immune responses.

  18. OSCAR (osteoclast associated immunoglobulin-like receptor)is expressed by erosion front osteoclasts and by synovial microvessels mononuclear cells. OSCAR is induced in monocytes of rheumatod arthritis patients, facilitating osteoclast differentiation

OSCAR Protein Profile

Protein Summary

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with OSCAR

  • osteoclast associated, immunoglobulin-like receptor (OSCAR)
  • osteoclast-associated immunoglobulin-like receptor (LOC748876)
  • osteoclast associated receptor (Oscar)
  • osteoclast associated, immunoglobulin-like receptor (Oscar)
  • mOSCAR protein
  • mOSCAR-M1 protein
  • mOSCAR-M2 protein
  • mOSCAR-M3 protein
  • OSCAR protein
  • PIgR-3 protein
  • PIGR3 protein
  • RGD1559897 protein

Protein level used designations for OSCAR

osteoclast associated, immunoglobulin-like receptor , osteoclast associated, immunoglobulin-like receptor, isoform 4 , ocl178 , osteoclast-associated immunoglobulin-like receptor , osteoclast-associated receptor OSCAR , osteoclast associated receptor OSCAR-S1 , osteoclast associated receptor OSCAR-S2 , poly-Ig receptor 3 , polymeric immunoglobulin receptor 3 , osteoclast associated receptor

GENE ID SPECIES
484313 Canis lupus familiaris
748876 Pan troglodytes
100137562 Papio anubis
232790 Mus musculus
126014 Homo sapiens
292537 Rattus norvegicus
100351627 Oryctolagus cuniculus
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