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Osteoclast Associated Receptor (OSCAR) (AA 19-282) protein (His tag) Protein

OSCAR Origin: Human Source: Baculovirus infected Insect Cells Recombinant > 90 % by SDS - PAGE SDS
Catalog No. ABIN5855171
$646.15
Plus shipping costs $45.00
50 μg ABIN5855171
50 μg ABIN5855171
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  • Protein Name
    Protein Type
    Recombinant
    Protein Characteristics
    AA 19-282
    Origin
    Human
    Source
    Baculovirus infected Insect Cells
    Purification tag / Conjugate
    This OSCAR protein is labelled with His tag.
    Application
    SDS-PAGE (SDS)
    Sequence
    DITPSVPPAS YHPKPWLGAQ PATVVTPGVN VTLRCRAPQP AWRFGLFKPG EIAPLLFRDV SSELAEFFLE EVTPAQGGSY RCCYRRPDWG PGVWSQPSDV LELLVTEELP RPSLVALPGP VVGPGANVSL RCAGRLRNMS FVLYREGVAA PLQYRHSAQP WADFTLLGAR APGTYSCYYH TPSAPYVLSQ RSEVLVISWE GEGPEARPAS SAPGMQAPGP PPSDPGAQAP SLSSFRPRGL VLQPLLPQTQ DSWDPAPPPS DPGVHHHHHH
    Purity
    > 90 % by SDS - PAGE
    Endotoxin Level
    < 1.0 EU per 1ug of protein (determined by LAL method)
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
  • Protein Name
    Background
    OSCAR, also known as osteoclast-associated immunoglobulin-like receptor isoform 6, is an activating receptor expressed by human myeloid cells. It is a receptor for surfactant protein D that activates TNF-alpha release from human CCR2+ inflammatory monocytes. It is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells. Its expression is detected specifically in preosteoclasts or mature osteoclasts. It is upregulated on monocytes from rheumatoid arthritis (RA) patients with active disease, and these monocytes show an increased proosteoclastogenic potential. Recombinant human OSCAR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
    Molecular Weight
    29.2kDa (270aa) 40-57kDa (SDS-PAGE under reducing conditions)
    NCBI Accession
    NP_001269278
    UniProt
    Q8IYS5
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