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OSBPL8 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Additionally we are shipping Oxysterol Binding Protein-Like 8 Kits (7) and Oxysterol Binding Protein-Like 8 Proteins (5) and many more products for this protein.
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ORP5 (show OSBPL5 Antibodies)/8 are endoplasmic reticulum (ER) membrane proteins implicated in lipid trafficking that localize to ER-plasma membrane (PM) contacts and maintain membrane homeostasis. Here the authors show that PtdIns(4,5)P 2 plays a critical role in the targeting and function of ORP5 (show OSBPL5 Antibodies)/8 at the PM.
we found that overexpression of ORP8 significantly inhibits GC cell proliferation and implanted tumor growth in vivo. Induction of ER stress, inhibition of Wnt (show WNT2 Antibodies) signaling, and apoptotic cell death are involved in ORP8-induced inhibition of GC cell proliferation.
mammalian ORP5 (show OSBPL5 Antibodies) and ORP8 proteins localize to ER-mitochondrial MCS (show SMCP Antibodies), in addition to ER-PM contact sites.
the present study suggests that ORP8 may mediate the cytotoxicity of 25-hydroxycholesterol.
ORP5 (show OSBPL5 Antibodies) and ORP8 could mediate PI4P/phosphatidylserine (PS) countertransport between the endoplasmic reticulum (ER) and the plasma membrane (PM), thus delivering PI4P to the ER-localized PI4P phosphatase Sac1 (show SACM1L Antibodies) for degradation and PS from the ER to the PM.
role of ORP8 in Fas (show FAS Antibodies) translocation to the plasma membrane and its down-regulation by miR (show MLXIP Antibodies)-143 offer a putative mechanistic explanation for HCC (show FAM126A Antibodies) resistance to apoptosis
Data indicate that miR (show MLXIP Antibodies)-143 impairs insulin (show INS Antibodies) action via downregulation of oxysterol-binding protein-related protein 8 (ORP8).
ORP8 overexpression resulted in reduced expression of the aP2 (show GTF3A Antibodies) mRNA, while down-regulation of adiponectin and aP2 (show GTF3A Antibodies) was observed in ORP11 (show OSBPL11 Antibodies) silenced cells. ORP8 overexpression or silencing of ORP11 (show OSBPL11 Antibodies) markedly decreased cellular triglyceride storage.
results reveal that ORP8 has the capacity to modulate lipid homeostasis and SREBP activity, probably through an indirect mechanism, and provide clues of an entirely new mode of ORP action
Data identify ORP8 as a negative regulator of ABCA1 (show ABCA1 Antibodies) expression and macrophage cholesterol efflux. ORP8 may, thus, modulate the development of atherosclerosis.
Orp8 deficiency in bone marrow-derived cells reduces atherosclerotic lesion progression in LDL receptor (show LDLR Antibodies) knockout mice.
Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism.
aspects of ORP8 function in macrophages not directly involving lipid metabolism, but rather associated with nuclear functions, microtubule organization, and migration capacity
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene.
oxysterol-binding protein-related protein 8
, oxysterol binding protein-like 8
, oxysterol-binding protein-like protein 8
, oxysterol-binding protein-related protein 8-like
, OSBP-related protein 8