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POU3F3 is a member of the class III POU family of transcription factors (see POU3F1\; MIM 602479) that are expressed in the central nervous system.
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Mouse (Murine) Polyclonal POU3F3 Primary Antibody for ELISA, WB - ABIN4346888
Castro, Skowronska-Krawczyk, Armant, Donaldson, Parras, Hunt, Critchley, Nguyen, Gossler, Göttgens, Matter, Guillemot: Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. in Developmental cell 2006
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Data show that the long noncoding RNA encoded by a gene next to POU3F3 (linc-POU3F3) is a potential therapeutic target and novel molecular biomarker for colorectal cancer (CRC (show CALR Antibodies)).
linc-POU3F3 might affect glioma development via altering expression level of POU3F3, and may also have a crucial regulatory role in glioma progression
Long intergenic non-protein coding RNA POU3F3 contributes to the development of ESCC by interacting with EZH2 (show EZH2 Antibodies) to promote methylation of POU3F3, which encodes a transcription factor.
The results of the present study confirm the important function of POU3F3 in nephron patterning, especially in development of the the Thick Ascending Limb of the Loop of Henle. Missense Mutation of POU Domain Class 3 Transcription Factor 3 in Pou3f3L423P Mice Causes Reduced Nephron Number and Impaired Development of the Thick Ascending Limb of the Loop of Henle.
results suggest that a mutually repressive mechanism exists between Brn1/2 and Rorb (show RORB Antibodies) expression and that the established expression of Brn1/2 and Rorb (show RORB Antibodies) further specifies those neurons into L2/3 and L4, respectively, during UCP (show UCP1 Antibodies) maturation
Line Pou3f3L423P is a viable mouse model harboring a homozygous Pou3f3 mutation.
Brn1 predominantly forms homomdimers on MORE cis (show CISH Antibodies) elements in NS5 (show RAF1 Antibodies) mouse neural stem cells
Onset of Pou3f3 expression occurs in ventricular zone progenitors, and that Pou3f3 subsequently label neural progeny switching from deep-layer Ctip2 (show BCL11B Antibodies)+ identity to Satb2 (show SATB2 Antibodies)+ upper-layer fate as they migrate to proper superficial positions.
Brn-1 and Brn-2 (show POU3F2 Antibodies) appear to critically control the initiation of radial migration, redundantly regulating the cell-autonomous expression of the p35 (show CDK5R1 Antibodies) and p39 (show ATP6V0D1 Antibodies) regulatory subunits of Cdk5 (show CDK5 Antibodies) in migrating cortical neurons
Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons
These results suggest that Brn1 is essential for both the development and function of the nephron in the kidney.
Brn-1 was shown to be capable of fully replacing the related Oct-6 (show POU3F1 Antibodies) in Schwann cell development.
Sox2 and SF1 may mediate basal nestin expression in undifferentiated cells, whereas Sox2, Brn1, and Brn2 bind to the enhancer in neural progenitor cells.
POU3F3 is a member of the class III POU family of transcription factors (see POU3F1\; MIM 602479) that are expressed in the central nervous system. The POU domain in these proteins is required for high affinity binding to octamer DNA sequences (summarized by Sumiyama et al., 1996
, POU domain, class 3, transcription factor 3
, brain-specific homeobox/POU domain protein 1
, octamer-binding protein 8
, octamer-binding transcription factor 8
, brn-1 protein
, class III POU protein POU-domain
, nrl-20 POU-homeobox protein