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PROP1 encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Additionally we are shipping PROP1 Proteins (9) and many more products for this protein.
Showing 10 out of 30 products:
Human Polyclonal PROP1 Primary Antibody for ELISA - ABIN4240033
Kelberman, Turton, Woods, Mehta, Al-Khawari, Greening, Swift, Otonkoski, Rhodes, Dattani: Molecular analysis of novel PROP1 mutations associated with combined pituitary hormone deficiency (CPHD). in Clinical endocrinology 2009
Genomic profiling reveals that PROP1 binds to genes expressed in epithelial cells like Claudin 23 (show CLDN23 Antibodies), and to epithelial-mesenchymal transition inducer genes like Zeb2 (show ZEB2 Antibodies), Notch2 (show NOTCH2 Antibodies) and Gli2 (show GLI2 Antibodies). Zeb2 (show ZEB2 Antibodies) activation appears to be a key step in the epithelial-mesenchymal transition process.
SOX2 (show SOX2 Antibodies) is a regulatory factor of Prop1 expression
Data show that human paired like homeodomain factor 1 (PROP1) can substitute functionally for mouse Prop1.
endocochlear potential and KCNJ10 (show KCNJ10 Antibodies) immunostaining in the stria vascularis are indistinguishable from wild type, and no differences in neurofilament or synaptophysin (show SYP Antibodies) staining are evident in Prop1(df) mutants
Data report the spatial and temporal regulation of Otx2 (show OTX2 Antibodies) in normal mice and Prop1 mutant.
Several components of the main GH-signaling pathways exhibit enhanced sensitivity to the hormone in liver and muscle of Ames dwarf mice.
Studies suggest that TLE1 (show TLE1 Antibodies) and TLE3 (show TLE3 Antibodies) might also play roles independent of HESX1 (show HESX1 Antibodies) by interacting with other transcription factors like PROP1.
Lhx4 (show LHX4 Antibodies) and Prop1 have critical, but mechanistically different roles in specification and expansion of specialized anterior pituitary cells
Tcf4 (show TCF4 Antibodies) and Aes (show AES Antibodies) influence pituitary growth and development, and place Tcf4 (show TCF4 Antibodies) and Tle3 (show TLE3 Antibodies) in the genetic hierarchy with Prop1
PROP1 has a role in pituitary gland growth
PROP1 mutations are a prevalent cause of congenital CPHD with OPP, and therefore, PROP1 sequencing must be the first step of molecular investigation in patients with CPHD and OPP, especially in populations with a high frequency of PROP1 mutations.
Deletion in the PROP1 gene is associated with Combined pituitary hormone (show CGA Antibodies) deficiency.
The anterior pituitary gland comprised specialized cell-types that arise from stem cells expressing SOX2 (show SOX2 Antibodies) and PROP1, which is necessary to establish the stem cell pool and promote an epithelial to mesenchymal-like transition, releasing progenitors from the niche. [review]
GH replacement successfully corrects the growth deficit in children with Growth Hormone Deficiency . While the genetic aetiology remains undefined in most cases of Isolated Growth Hormone Deficiency , PROP1 mutations constitute a major cause for Multiple Pituitary Hormone Deficiencies. Persistence of Growth Hormone Deficiency into adulthood is related to abnormal pituitary morphology.
The present study reports on screening of POU1F1 (show POU1F1 Antibodies), PROP1, and HESX1 (show HESX1 Antibodies) in combined pituitary hormone (show CGA Antibodies) deficiency patients and the novel variations identified.
A compound heterozygosity in the PROP1 gene has been identified for both probands. The first change represents a mutational hot spot (c.150delA, p.R53fsX164), whereas the second is a novel alteration (p.R112X) that leads to protein disruption. The resulting clinical phenotype was surprisingly distinct compared to most patients with genetic alterations in PROP1.
the most frequent variants in the PROP1 gene are not a consequence of variant hot spots as previously assumed, but are founder variants.
A novel heterozygous mutation in the HESX1 (show HESX1 Antibodies) gene and a novel homozygous mutation in the PROP1 gene were detected in 2 pedigrees with combined pituitary hormone (show CGA Antibodies) deficiency
The c.301_302delAG homozygous genotype had a high frequency of 38%, reaching 100% in group with familial cases of multiple pituitary hormone (show CGA Antibodies) deficiency and 16% in group with sporadic forms of MPHD.
Data suggest that formation of a heterodimer between HESX1 (show HESX1 Antibodies) and PROP1 allows HESX1 (show HESX1 Antibodies) to become active, and that PROP1 then replaces HESX1 (show HESX1 Antibodies) to advance to the middle stage of pituitary development.
Prop-1 participates in the regulation of FSHbeta gene
Prop-1 might be involved in development of gonadotropes and hormone production
Dimeric binding of PROP1 is able to recognize diverse palindromic TAAT sequences separated by 3 nucleotides and to exhibit its transcriptional activity.
The H173R mutation in PROP1 can be considered as a DNA marker for selecting individuals with superior growth traits, thereby contributing to research on breeding and genetics in the beef industry.
This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone.
, homeobox protein prophet of Pit-1
, pituitary specific homeodomain factor
, pituitary-specific homeodomain factor
, prophet of Pit-1
, PROP paired-like homeobox 1
, prophet of Pit1, paired-like homeodomain transcription factor
, paired like homeodomain factor 1
, prophet of Pit1 paired-like homeodomain transcription factor