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The protein encoded by PHOX2A contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product.
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Human Polyclonal PHOX2A Primary Antibody for ELISA, WB - ABIN4345384
Fan, Huang, Kieran, Zhu: Effects of transcription factors Phox2 on expression of norepinephrine transporter and dopamine beta-hydroxylase in SK-N-BE(2)C cells. in Journal of neurochemistry 2009
PHOX2A expression is finely controlled during retinoic acid differentiation and this, together with PHOX2B (show PHOX2B Antibodies) down-regulation.
Genetic linkage was found at 11q13 between D11S4151 and D11S1320 and the PHOX2A gene.
Patients with ARIX and/or PHOX2B (show PHOX2B Antibodies) polymorphisms had less hypoplastic superior oblique muscles.
The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase (show DBH Antibodies) gene transcription through its phosphorylation status
PHOX2A mutation analysis revealed a novel nonsense mutation in CFEOM2 (congenital fibrosis of extraocular muscles type 2)
the polymorphisms of the ARIX gene and PHOX2B (show PHOX2B Antibodies) gene may be genetic risk factors for the development of congenital superior oblique muscle palsy
PHOX2A, but not PHOX2B (show PHOX2B Antibodies), seems to act directly on the c-RET (show RET Antibodies) promoter
Together, these results suggest that phosphorylation of Arix by ERK1/2 inhibits its ability to interact with target genes, and that both specificity of expression and modulation by external stimuli are monitored through the same transcription factor.
These results demonstrate the direct interactions of the Phox2a and b and dHAND (show HAND2 Antibodies) transcription factors within a noradrenergic cell type
the alpha3 subunit is expressed in every terminally differentiated ganglionic cell, this is the first example of a "pan (show SUPT6H Antibodies)-autonomic" gene whose expression is regulated by PHOX2 proteins.
All E1 sequences from lamprey to mouse responded equally well to Phox2a and the Isl1 (show ISL1 Antibodies)-Lhx3 (show LHX3 Antibodies) complex. Conversely, E2, the enhancer for limb-innervating motor neurons, was only found in tetrapod animals
reveal an unanticipated role for Lmx1b (show LMX1B Antibodies) in regulating Phox2a expression and the sequential specification of ocular motor neurons (OMNs) and red nucleus neurons (RNNs) from progenitors located lateral to dopamine neurons in the midbrain
Maintenance of noradrenergic differentiation during embryogenesis requires ongoing expression of Phox2b (show PHOX2B Antibodies) in sympathetic ganglia, and of Phox2a in the main noradrenergic center, the locus coeruleus.
Noradrenaline, A6 neurons, and the Phox2a gene, which is crucial for the generation of A6 neurons, are essential for development of normal respiratory rhythm in neonatal mice
Phox2 genes have roles in neural differentiation
These data indicate that Phox2a plays a critical role in the ontogeny of the reflex control of inspiration.
The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles.
ARIX1 homeodomain protein
, aristaless homeobox homolog
, aristaless homeobox protein homolog
, arix homeodomain protein
, paired mesoderm homeobox protein 2A
, PHOX2A homeodomain protein
, aristaless homeobox gene homolog
, paired mesoderm homeobox 2a
, aristaless homeobox
, paired-like (aristaless) homeobox 2a