Platelet Factor 4 Proteins (PF4)

PF4 encodes a member of the CXC chemokine family. Additionally we are shipping Platelet Factor 4 Antibodies (184) and Platelet Factor 4 Kits (114) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PF4 5196 P02776
PF4 56744 Q9Z126
PF4 360918 P06765
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Top Platelet Factor 4 Proteins at antibodies-online.com

Showing 10 out of 78 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 10 to 12 Days
$684.38
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Mouse Un-conjugated   10 μg Log in to see 10 to 12 Days
$146.23
Details
Escherichia coli (E. coli) Human His tag 20 μg Log in to see 2 to 3 Days
$295.00
Details
Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 14 to 16 Days
$570.06
Details
Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 15 to 18 Days
$560.00
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$720.00
Details
Escherichia coli (E. coli) Mouse Un-conjugated   50 μg Log in to see 2 to 3 Days
$575.00
Details
Escherichia coli (E. coli) Human Un-conjugated Validation with Western Blot 20 μg Log in to see 4 to 8 Days
$319.00
Details

PF4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, ,
Mouse (Murine)
,
Rat (Rattus) ,
,

More Proteins for Platelet Factor 4 (PF4) Interaction Partners

Human Platelet Factor 4 (PF4) interaction partners

  1. results identify PF4 as a ligand for the integrin Mac-1 and suggest that many immune-modulating effects previously ascribed to PF4 are mediated through its interaction with Mac-1

  2. Bacteremia/sepsis was associated with higher anti-PF4/heparin antibody titers. There was no difference between Gram negative/positive bacteremia and antibody titer.

  3. CXCL4 boosts pro-inflammatory cytokine production especially IL-17 by CD4(+) T cells, either by acting directly or indirectly via myeloid antigen presenting cells, implicating a role for CXCL4 in psoriatic arthritis pathology.

  4. The data show that antibodies magnify immune responses induced in PBMCs by PF4 alone or in complex with heparin or LMWH. Authors propose that following induction of HIT antibodies by heparin-PF4 complexes, binding of the antibodies to PF4 is sufficient to induce a local pro-inflammatory response which may play a role in the progression of HIT.

  5. Report anti-PF4/H monoclonal antibody with a human Fc fragment, which induces similar cellular activation as heparin-induced thrombocytopenia antibodies.

  6. PF4 was produced by Ly6G+CD11b+ immature myeloid cells in the early stage premetastatic lungs, and decreased during metastatic progression.

  7. The CXCL4 monomer acts as the minimal active unit for interacting with CXCR3 N-Terminal Sulfated Peptide, and sulfation of N-terminal tyrosine residues on the receptor is important for binding.

  8. These findings support PF4 as a cancer-enhancing endocrine signal that controls discrete aspects of bone marrow hematopoiesis and tumor microenvironment.

  9. data support that increased levels of circulating CXCL4 may contribute to immune dysregulation through the modulation of dendritic cell differentiation

  10. Endometrial CXCL4 mRNA concentrations were significantly increased during menstruation. In women with heavy menstrual bleeding, CXCL4 was reduced in endothelial cells during the menstrual phase compared with women with normal menstrual bleeding. These data implicate CXCL4 in endometrial repair after menses.

  11. Two haplotype blocks, one upstream to the coding region of UGT2A1 (rs146712414, P = 9.1 x 10(-5); odds ratio [OR], 1.34; 95% confidence interval [CI], 1.16-1.56) and one downstream of the genes PF4/PPBP/CXCL5 (rs1595009, P = 1.3 x 10(-4); OR, 1.32; 95% CI, 1.15-1.52), were associated with AgP.

  12. These data demonstrate that the CXCR2 network and CXCL4 play a role in the maintenance of normal HSC/HPC cell fates, including survival and self-renewal.

  13. The major aim of this review article was to evaluate the role of CXCL4 in hematological malignancies, promotion of HSC quiescence as well as BM niche cells.

  14. binding of PF4 to perlecan was found to inhibit both FGF2 signaling and platelet activation

  15. CXCL4 plays an important role in pancreatic inflammation

  16. Data suggest that serum haptoglobin, fetuin-A, platelet factor-4, hs-CRP (high sensitive-C-reactive protein), SAP (serum amyloid P), AGP (alpha1-acid glycoprotein) levels of adolescents with metabolic syndrome are significantly higher than those of controls subjects.

  17. The hitherto unknown association of increased serum CXCL4 with features of microvascular impairment in primary Sjogren's syndrome, along with the negative association with features of lymphocytic response suggest clarifying the possible implication of this chemokine in primary Sjogren's syndrome pathogenesis in larger studies.

  18. serum concentration of CXCL4 was significantly increased in patients with Chronic Liver Allograft Dysfunction (CLAD); CXCL4 mRNA was significantly increased in subjects with CLAD versus individuals without CLAD

  19. Plasma levels of CXCL4 are associated with tumour vascularity.

  20. Data suggest that, in patients with hypothyroid autoimmune thyroiditis, PF4/CXCL4 serum levels are significantly lower in those with subclinical hypothyroidism than in euthyroid control subjects.

Mouse (Murine) Platelet Factor 4 (PF4) interaction partners

  1. these data demonstrate that PF4 has an important role in increasing B cell differentiation in the bone marrow environment

  2. these results identify CXCL4 as a vital immunoregulatory chemokine essential for protecting mice against influenza A virus infection, especially as it affects the development of lung injury and neutrophil mobilization to the inflamed lung

  3. These results indicate that CXCL4 is a novel Ni-binding protein that augments Ni allergy at the elicitation and sensitization phases. This is the first study to demonstrate that the Ni-binding protein augments Ni allergy in vivo.

  4. PF4 was produced by Ly6G+CD11b+ immature myeloid cells in the early stage premetastatic lungs, and decreased during metastatic progression.

  5. These data demonstrate that the CXCR2 network and CXCL4 play a role in the maintenance of normal HSC/HPC cell fates, including survival and self-renewal.

  6. Platelet-derived CXCL7 and CXCL4 contribute to the pathogenesis of acute lung injury.

  7. CXCL4 plays an important role in pancreatic inflammation

  8. Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage

  9. PF4 has a complex intramedullary life cycle with important implications in megakaryopoiesis and hematopoietic stem cell replication not seen with other tested alpha granule proteins.

  10. Heparin enhances antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes.

  11. Data indicate that platelet factor 4 (PF4) is involved directly in liver innate immune response against ischaemia-reperfusion injury (IRI) by regulating Th17 cell differentiation.

  12. CXCL4 regulates hematopoietic stem cell cell cycle activity.

  13. Platelet factor 4 has a role in regulating Th17 differentiation and cardiac allograft rejection

  14. Histones regulate activated protein C formation in a manner similar to PF4 and suggest heparinoids may be benificial in sepsis.

  15. PF4 drives a vascular smooth muscle inflammatory phenotype including a decline in differentiation markers, increased cytokine production, and cell proliferation.

  16. Peptide inhibition of CXCL4-CCL5 interactions may represent a viable translational strategy to limit progression of abdominal aortic aneurysms.

  17. PF4 expression on intestinal epithelial cells is increased after IR at both the mRNA and protein levels. In conclusion, these findings demonstrate that may PF4 represent an important mediator of local and remote tissue damage.

  18. These results suggest that Cxcl4 and Cxcl7 play a role in the development of neurobehavioral alterations that are triggered by in utero TCDD exposure and later surface in adults.

  19. PF4 may have a role in bacterial defense, and heparin-induced thrombocytopenia is probably a misdirected antibacterial host defense mechanism.

  20. In vivo, half-life and diffusibility of CXCL4L1 compared with Cxcl4 is strongly increased.

Platelet Factor 4 (PF4) Protein Profile

Protein Summary

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function.

Gene names and symbols associated with Platelet Factor 4 Proteins (PF4)

  • platelet factor 4 (PF4)
  • platelet factor 4 (Pf4)
  • platelet factor 4 (LOC703451)
  • platelet factor 4 (LOC100524373)
  • platelet factor 4 (LOC102181854)
  • platelet factor 4 (LOC100630489)
  • Cxcl4 protein
  • PF-4 protein
  • PF4 protein
  • Pf4a protein
  • RATPF4A protein
  • Scyb4 protein

Protein level used designations for Platelet Factor 4 Proteins (PF4)

C-X-C motif chemokine 4 , chemokine (C-X-C motif) ligand 4 , iroplact , oncostatin-A , PF-4 , platelet factor 4 (chemokine (C-X-C motif) ligand 4) , platelet factor 4

GENE ID SPECIES
5196 Homo sapiens
56744 Mus musculus
360918 Rattus norvegicus
507790 Bos taurus
703451 Macaca mulatta
740477 Pan troglodytes
101104401 Ovis aries
102181854 Capra hircus
100630489 Equus caballus
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