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PF4 encodes a member of the CXC chemokine family. Additionally we are shipping Platelet Factor 4 Antibodies (184) and Platelet Factor 4 Kits (111) and many more products for this protein.
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The data show that antibodies magnify immune responses induced in PBMCs by PF4 alone or in complex with heparin or LMWH. Authors propose that following induction of HIT antibodies by heparin-PF4 complexes, binding of the antibodies to PF4 is sufficient to induce a local pro-inflammatory response which may play a role in the progression of HIT.
Report anti-PF4/H monoclonal antibody with a human Fc fragment, which induces similar cellular activation as heparin-induced thrombocytopenia antibodies.
PF4 was produced by Ly6G+CD11b (show ITGAM Proteins)+ immature myeloid cells in the early stage premetastatic lungs, and decreased during metastatic progression.
The CXCL4 monomer acts as the minimal active unit for interacting with CXCR3 (show CXCR3 Proteins) N-Terminal Sulfated (show SULF1 Proteins) Peptide, and sulfation of N-terminal tyrosine residues on the receptor is important for binding.
These findings support PF4 as a cancer-enhancing endocrine signal that controls discrete aspects of bone marrow hematopoiesis and tumor microenvironment.
data support that increased levels of circulating CXCL4 may contribute to immune dysregulation through the modulation of dendritic cell differentiation
Endometrial CXCL4 mRNA concentrations were significantly increased during menstruation. In women with heavy menstrual bleeding, CXCL4 was reduced in endothelial cells during the menstrual phase compared with women with normal menstrual bleeding. These data implicate CXCL4 in endometrial repair after menses.
Two haplotype blocks, one upstream to the coding region of UGT2A1 (rs146712414, P = 9.1 x 10(-5); odds ratio [OR], 1.34; 95% confidence interval [CI], 1.16-1.56) and one downstream of the genes PF4/PPBP/CXCL5 (rs1595009, P = 1.3 x 10(-4); OR, 1.32; 95% CI, 1.15-1.52), were associated with AgP.
These data demonstrate that the CXCR2 (show CXCR2 Proteins) network and CXCL4 play a role in the maintenance of normal HSC (show FUT1 Proteins)/HPC cell fates, including survival and self-renewal.
The major aim of this review article was to evaluate the role of CXCL4 in hematological malignancies, promotion of HSC (show FUT1 Proteins) quiescence as well as BM niche cells.
these data demonstrate that PF4 has an important role in increasing B cell differentiation in the bone marrow environment
these results identify CXCL4 as a vital immunoregulatory chemokine (show CCL1 Proteins) essential for protecting mice against influenza A virus infection, especially as it affects the development of lung injury and neutrophil mobilization to the inflamed lung
These results indicate that CXCL4 is a novel Ni-binding protein that augments Ni allergy at the elicitation and sensitization phases. This is the first study to demonstrate that the Ni-binding protein augments Ni allergy in vivo.
Platelet-derived CXCL7 (show PPBP Proteins) and CXCL4 contribute to the pathogenesis of acute lung injury.
CXCL4 plays an important role in pancreatic inflammation
Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage
PF4 has a complex intramedullary life cycle with important implications in megakaryopoiesis and hematopoietic stem cell replication not seen with other tested alpha granule proteins.
Heparin enhances antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes.
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function.
C-X-C motif chemokine 4
, chemokine (C-X-C motif) ligand 4
, platelet factor 4 (chemokine (C-X-C motif) ligand 4)
, platelet factor 4