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PF4 encodes a member of the CXC chemokine family. Additionally we are shipping Platelet Factor 4 Antibodies (166) and Platelet Factor 4 Kits (107) and many more products for this protein.
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The CXCL4 monomer acts as the minimal active unit for interacting with CXCR3 (show CXCR3 Proteins) N-Terminal Sulfated (show SULF1 Proteins) Peptide, and sulfation of N-terminal tyrosine residues on the receptor is important for binding.
These findings support PF4 as a cancer-enhancing endocrine signal that controls discrete aspects of bone marrow hematopoiesis and tumor microenvironment.
data support that increased levels of circulating CXCL4 may contribute to immune dysregulation through the modulation of dendritic cell differentiation
Endometrial CXCL4 mRNA concentrations were significantly increased during menstruation. In women with heavy menstrual bleeding, CXCL4 was reduced in endothelial cells during the menstrual phase compared with women with normal menstrual bleeding. These data implicate CXCL4 in endometrial repair after menses.
Two haplotype blocks, one upstream to the coding region of UGT2A1 (rs146712414, P = 9.1 x 10(-5); odds ratio [OR], 1.34; 95% confidence interval [CI], 1.16-1.56) and one downstream of the genes PF4/PPBP/CXCL5 (rs1595009, P = 1.3 x 10(-4); OR, 1.32; 95% CI, 1.15-1.52), were associated with AgP.
These data demonstrate that the CXCR2 (show CXCR2 Proteins) network and CXCL4 play a role in the maintenance of normal HSC (show FUT1 Proteins)/HPC cell fates, including survival and self-renewal.
The major aim of this review article was to evaluate the role of CXCL4 in hematological malignancies, promotion of HSC (show FUT1 Proteins) quiescence as well as BM niche cells.
binding of PF4 to perlecan (show HSPG2 Proteins) was found to inhibit both FGF2 (show FGF2 Proteins) signaling and platelet activation
CXCL4 plays an important role in pancreatic inflammation
Data suggest that serum haptoglobin, fetuin-A, platelet factor-4, hs-CRP (high sensitive-C-reactive protein), SAP (serum amyloid P), AGP (alpha1-acid glycoprotein) levels of adolescents with metabolic syndrome are significantly higher than those of controls subjects.
Platelet-derived CXCL7 (show PPBP Proteins) and CXCL4 contribute to the pathogenesis of acute lung injury.
Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage
PF4 has a complex intramedullary life cycle with important implications in megakaryopoiesis and hematopoietic stem cell replication not seen with other tested alpha granule proteins.
Heparin enhances antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes.
Data indicate that platelet factor 4 (PF4) is involved directly in liver innate immune response against ischaemia-reperfusion injury (IRI) by regulating Th17 cell differentiation.
CXCL4 regulates hematopoietic stem cell cell cycle activity.
Platelet factor 4 has a role in regulating Th17 differentiation and cardiac allograft rejection
Histones regulate activated protein C (show PROC Proteins) formation in a manner similar to PF4 and suggest heparinoids may be benificial in sepsis.
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function.
platelet factor 4 (chemokine (C-X-C motif) ligand 4)
, C-X-C motif chemokine 4
, chemokine (C-X-C motif) ligand 4