anti-Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) Antibodies

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). Additionally we are shipping Pleckstrin Homology Domain Containing, Family O Member 1 Kits (11) and Pleckstrin Homology Domain Containing, Family O Member 1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PLEKHO1 51177 Q53GL0
PLEKHO1 67220 Q9JIY0
PLEKHO1 310674 Q5BJM5
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Top anti-Pleckstrin Homology Domain Containing, Family O Member 1 Antibodies at antibodies-online.com

Showing 10 out of 57 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PLEKHO1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  COLO205 cell lysate WB Suggested Anti-PLEKHO1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: COLO205 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of CKIP-1 Antibody (N-term) (ABIN652439) in 293 cell line lysates (35 µg/lane). CKIP-1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human skeletal muscle reacted with CKIP-1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$484.00
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Human Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-PLEKHO1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 4 to 8 Days
$474.10
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti CKIP-1 Polyclonal Antibody, Unconjugated (ABIN675039) at 1:200 followed by conjugation to the secondary antibody and DAB staining Lane 1: mouse heart lysates Lane 2: mouse kidney lysates probed with Anti CKIP-1 Polyclonal Antibody, Unconjugated (ABIN675039) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 45kD. Observed band size: 45kD. 100 μL Log in to see 3 to 7 Days
$317.90
Details
Human Mouse Un-conjugated ELISA, IHC, IHC (p) 100 μg Log in to see 11 to 14 Days
$537.17
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB 50 μg Log in to see 12 to 14 Days
$686.14
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE) Western blot analysis of CKIP1 in human lung tissue lysate with CKIP1 antibody at (A) 1 and (B) 2 µg/ml. 50 μg Log in to see 6 to 8 Days
$495.00
Details

More Antibodies against Pleckstrin Homology Domain Containing, Family O Member 1 Interaction Partners

Human Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) interaction partners

  1. we firstly revealed the association of CKIP-1 rs2306235 polymorphism with an increased risk of CHF in Chinese Han populations.

  2. we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation.

  3. these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization.

  4. the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.

  5. High expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis.

  6. New light on the molecular mechanism of cell adhesion-mediated drug resistance in Non-Hodgkin's Lymphoma (NHL) and targeting CKIP-1 may be a novel therapeutic target for NHL.

  7. There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 for neoplastic prostate cells transformation.

  8. CKIP-1 interacts with CARMA1 and has an inhibitory effect on PKCtheta;-CBM-NF-kappaB signaling.

  9. CKIP-1 controlled Smurf1 expression in colon cancer

  10. overexpression triggers classical monocyte activation and transactivation of the TNF promoter

  11. CKIP-1, through its leucine zipper, interacts with the Rpt6 and mediates the Smurf1-Rpt6 interaction.

  12. CKIP-1 is involved in various important signaling pathways, controlling cell growth, apoptosis, differentiation, cytoskeleton and bone formation--REVIEW

  13. The N-terminal PH domain and C-terminal auto-inhibitory region of CKIP-1 coordinate to determine its subcellular localization and the nucleus-plasma membrane shuttling.

  14. examination of CK2alpha for a region that mediates interactions with CKIP-1 revealed a putative HIKE domain; this motif by itself may not be sufficient to mediate interactions.

  15. CKIP-1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein.

  16. Data provide evidence that ATM, a predominantly nuclear kinase, could be relocalized to the plasma membrane by CKIP-1.

  17. CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein

  18. The results provide a novel role of CKIP-1 in cytokine signaling response and the biochemical mechanism, by which two previously identified modulators IFP35 and Nmi are involved via interactions.

  19. Results indicate that CKIP-1, a novel Akt PH domain-interacting protein, would be a candidate of tumor suppressor with an Akt inhibitory function.

  20. CKIP-1 is cleaved by caspase-3 during apoptosis. C-terminal fragments translocate to the cytoplasm and nucleus and inhibit AP-1 activity via direct interaction with c-Jun and JunD. CKIP-1 also forms a feedback with caspase-3 and enhances apoptosis.

Mouse (Murine) Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) interaction partners

  1. The aim of this study was to investigate the effect of constrained dynamic loading (Loading) in combination with CKIP1 gene knockout (KO) on unloadinginduced bone loss in tailsuspension mice.

  2. the reduced bone formation in GIO mice could not only be prevented by osteoblasts-specific Ckip-1 ablation, but also be attenuated after osteoblasts-specific Smad1 overexpression

  3. we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation.

  4. PD increased CKIP-1 and Nrf2 levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1

  5. these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization.

  6. The results indicate that CKIP-1 deficiency in mice aggravates HFD-induced fatty liver by upregulating JNK1 phosphorylation and further upregulating IRS-1 phosphorylation and RI.

  7. the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.

  8. Data suggest CKIP1 (casein kinase 2 interacting protein-1) plays role in resistance to oxidative stress in glomerular mesangial cells in development of diabetic nephropathy; mechanisms appear to include down-regulation of expression of ICAM1 (intercellular adhesion molecule-1) and fibronectin plus activation of Nrf2/ARE (nuclear factor E2-related factor 2/antioxidant response element) antioxidative stress pathway.

  9. the effect of CKIP-1 on the regulation of bone metabolism and osteogenesis

  10. CKIP-1 is a novel inhibitor of MSC-originated adipogenesis by enhancing HDAC1-associated repression of C/EBPalpha.

  11. CKIP-1 interacts with TRAF6, a ubiquitin ligase required for K63-linked ubiquitination and plasma membrane recruitment of Akt, and terminates TRAF6-mediated Akt activation.

  12. Knockdown of CKIP-1 in RAW264.7 macrophage cells resulted in impaired cell migration.

  13. CKIP-1 was found to be an inhibitor of cardiac hypertrophy by upregulating the dephosphorylation of HDAC4 through the recruitment of protein phosphatase 2A.

  14. CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein

  15. CKIP-1 functions as the first auxiliary factor to enhance the activation of Smurf1.

Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) Antigen Profile

Protein Summary

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity).

Gene names and symbols associated with PLEKHO1

  • pleckstrin homology domain containing O1 (PLEKHO1) antibody
  • pleckstrin homology domain containing, family O member 1 (Plekho1) antibody
  • pleckstrin homology domain containing O1 (Plekho1) antibody
  • pleckstrin homology domain containing, family O member 1a (plekho1a) antibody
  • 2810052M02Rik antibody
  • ckip-1 antibody
  • Ckip1 antibody
  • JZA-20 antibody
  • Jza2 antibody
  • OC120 antibody
  • plekho1 antibody
  • RGD1311487 antibody
  • si:dkey-200h23.2 antibody

Protein level used designations for PLEKHO1

2810052M02Rik , C-Jun-binding protein , CK2 interacting protein 1; HQ0024c protein , CK2-interacting protein 1 , JBP , OC120 , PH domain-containing family O member 1 , casein kinase 2-interacting protein 1 , osteoclast maturation-associated gene 120 protein , pleckstrin homology domain-containing family O member 1 , pleckstrin homology domain containing, family O member 1 , CK2 interacting protein 1 , Jun zipper-associated 2 , TNF intracellular domain-interacting protein , CK2-interacting protein-1 , PH domain-containing family O member 1-A , pleckstrin homology domain-containing family O member 1-A

GENE ID SPECIES
51177 Homo sapiens
426108 Gallus gallus
457268 Pan troglodytes
607927 Canis lupus familiaris
706145 Macaca mulatta
788251 Bos taurus
100152184 Sus scrofa
100347162 Oryctolagus cuniculus
100444299 Pongo abelii
67220 Mus musculus
310674 Rattus norvegicus
563283 Danio rerio
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