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Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP).
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we firstly revealed the association of CKIP-1 rs2306235 polymorphism with an increased risk of CHF in Chinese Han populations.
we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation.
these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization.
the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.
High expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis.
New light on the molecular mechanism of cell adhesion-mediated drug resistance in Non-Hodgkin's Lymphoma (NHL (show RTEL1 Antibodies)) and targeting CKIP-1 may be a novel therapeutic target for NHL (show RTEL1 Antibodies).
There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 (show PAK1 Antibodies) for neoplastic prostate cells transformation.
CKIP-1 interacts with CARMA1 (show CARD11 Antibodies) and has an inhibitory effect on PKCtheta (show PRKCQ Antibodies);-CBM-NF-kappaB (show NFKB1 Antibodies) signaling.
CKIP-1 controlled Smurf1 (show SMURF1 Antibodies) expression in colon cancer
overexpression triggers classical monocyte activation and transactivation of the TNF (show TNF Antibodies) promoter
PD increased CKIP-1 and Nrf2 (show NFE2L2 Antibodies) levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1 (show ICAM1 Antibodies)
The results indicate that CKIP-1 deficiency in mice aggravates HFD-induced fatty liver by upregulating JNK1 (show MAPK8 Antibodies) phosphorylation and further upregulating IRS-1 (show IRS1 Antibodies) phosphorylation and RI.
Data suggest CKIP1 (casein kinase 2 interacting protein-1) plays role in resistance to oxidative stress in glomerular mesangial cells in development of diabetic nephropathy; mechanisms appear to include down-regulation of expression of ICAM1 (intercellular adhesion molecule-1 (show ICAM1 Antibodies)) and fibronectin (show FN1 Antibodies) plus activation of Nrf2 (show NFE2L2 Antibodies)/ARE (nuclear factor E2-related factor 2/antioxidant response element) antioxidative stress pathway.
the effect of CKIP-1 on the regulation of bone metabolism and osteogenesis
CKIP-1 is a novel inhibitor of MSC (show MSC Antibodies)-originated adipogenesis by enhancing HDAC1 (show HDAC1 Antibodies)-associated repression of C/EBPalpha (show CEBPA Antibodies).
CKIP-1 interacts with TRAF6 (show TRAF6 Antibodies), a ubiquitin ligase (show RNF123 Antibodies) required for K63-linked ubiquitination and plasma membrane recruitment of Akt (show AKT1 Antibodies), and terminates TRAF6 (show TRAF6 Antibodies)-mediated Akt (show AKT1 Antibodies) activation.
Knockdown of CKIP-1 in RAW264.7 macrophage cells resulted in impaired cell migration.
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity).
pleckstrin homology domain containing, family O member 1
, C-Jun-binding protein
, CK2 interacting protein 1; HQ0024c protein
, CK2-interacting protein 1
, PH domain-containing family O member 1
, casein kinase 2-interacting protein 1
, osteoclast maturation-associated gene 120 protein
, pleckstrin homology domain-containing family O member 1
, CK2 interacting protein 1
, Jun zipper-associated 2
, TNF intracellular domain-interacting protein