PLEKHO1 antibody (AA 143-404) (HRP)

Catalog No. ABIN7163661

Product Details anti-PLEKHO1 Antibody (HRP)

Target: PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))

Binding Specificity: AA 143-404

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLEKHO1 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Pleckstrin homology domain-containing family O member 1 protein (143-404AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PLEKHO1

Target: PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))

Alternative Name: PLEKHO1 (PLEKHO1 Products)

Synonyms: CKIP-1 antibody, OC120 antibody, 2810052M02Rik antibody, Ckip1 antibody, JZA-20 antibody, Jza2 antibody, RGD1311487 antibody, ckip-1 antibody, plekho1 antibody, si:dkey-200h23.2 antibody, pleckstrin homology domain containing O1 antibody, pleckstrin homology domain containing, family O member 1 antibody, pleckstrin homology domain containing, family O member 1a antibody, PLEKHO1 antibody, Plekho1 antibody, plekho1a antibody

Background:

Background: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.

Aliases: C-Jun-binding protein antibody, Casein kinase 2-interacting protein 1 antibody, CK2 interacting protein 1 antibody, CK2 interacting protein 1 HQ0024c protein antibody, CK2-interacting protein 1 antibody, CKIP 1 antibody, CKIP-1 antibody, CKIP1 antibody, JBP antibody, OC120 antibody, Osteoclast maturation associated gene 120 protein antibody, Osteoclast maturation-associated gene 120 protein antibody, PH domain-containing family O member 1 antibody, PKHO1_HUMAN antibody, Pleckstrin homology domain containing family O member 1 antibody, Pleckstrin homology domain-containing family O member 1 antibody, PLEKHO1 antibody

UniProt: Q53GL0