anti-Polymerase (RNA) Mitochondrial (DNA Directed) (POLRMT) Antibodies

POLRMT encodes a mitochondrial DNA-directed RNA polymerase. Additionally we are shipping POLRMT Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
POLRMT 299604  
POLRMT 5442 O00411
POLRMT 216151 Q8BKF1
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Top anti-POLRMT Antibodies at antibodies-online.com

Showing 10 out of 28 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: POLRMT Sample Type: OVCAR-3 Whole Cell lysates Antibody Dilution: 1.0ug/ml  POLRMT is supported by BioGPS gene expression data to be expressed in OVCAR3 100 μL 2 to 3 Days
$319.00
Details
Human Goat Un-conjugated ELISA   100 μg 6 to 7 Days
$291.53
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of POLRMT using MCF7 whole cell lysates 100 μL 11 to 12 Days
$390.77
Details
Human Mouse Un-conjugated ELISA   100 μg 11 to 14 Days
$551.83
Details
Human Goat Un-conjugated ELISA   100 μg 11 to 14 Days
$507.83
Details
Human Mouse Un-conjugated IF, ELISA Detection limit for recombinant GST tagged POLRMT is 0.3 ng/ml as a capture antibody. Immunofluorescence of monoclonal antibody to POLRMT on HeLa cell. [antibody concentration 10 ug/ml] 100 μg 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged POLRMT is 0.3 ng/ml as a capture antibody. Western Blot detection against Immunogen (36.74 KDa) . 100 μg 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated ELISA, WB POLRMT polyclonal antibody (A01), Lot # NOW0060302QCS1 Western Blot analysis of POLRMT expression in A-431 Western Blot detection against Immunogen (38.21 KDa) . 50 μL 11 to 12 Days
$305.71
Details
Human Rabbit Un-conjugated WB Western blot analysis POLRMT using MCF7 whole cell lysates. 100 μg 11 to 18 Days
$440.62
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μL 11 to 14 Days
$551.83
Details

Top referenced anti-POLRMT Antibodies

  1. Human Polyclonal POLRMT Primary Antibody for IHC - ABIN966880 : Tiranti, Savoia, Forti, DApolito, Centra, Rocchi, Zeviani: Identification of the gene encoding the human mitochondrial RNA polymerase (h-mtRPOL) by cyberscreening of the Expressed Sequence Tags database. in Human molecular genetics 1997 (PubMed)
    Show all 5 Pubmed References

More Antibodies against POLRMT Interaction Partners

Human Polymerase (RNA) Mitochondrial (DNA Directed) (POLRMT) interaction partners

  1. the frequency of variation in sequence identity and length at conserved sequence block 2 amongst human mitochondrial genomes and used in vitro transcription to assess the effects of this length heterogeneity on the activity of the mitochondrial RNA polymerase, POLRMT, was examined.

  2. Suggest targeting POLRMT as strategy for treating acute myeloid leukemia.

  3. knock-down of MRPL12 by RNA interference results in instability of POLRMT.

  4. Results show that polymorphisms at POLG2 and POLRMT increased risk of oral cancer and leukoplakia, respectively, probably modulating synthesis and activity of the enzymes.

  5. The results reveal the organization of TFAM, POLRMT and TFB2M around the light-strand promoter and represent the first structural characterization of the entire mitochondrial transcriptional initiation complex.

  6. The results demonstrate that human TFAM binds to the N-terminal domain of mtRNAP, which results in bending of the promoter DNA around mtRNAP.

  7. Newly synthesized RNA exits toward the pentatricopeptide repeat (PPR) domain, a unique feature of mtRNAP with conserved RNA-recognition motifs.

  8. Authors propose that POLRMT interacts directly with h-mtTFB1 in 28S mitochondrial ribosomes to augment its 12S rRNA methyltransferase activity.

  9. X-ray structure of human mtRNAP at 2.5 A resolution, which reveals a T7-like catalytic carboxy-terminal domain, an amino-terminal domain resembling the T7 promoter-binding domain, a novel pentatricopeptide repeat domain, and flexible N-terminal extension

  10. muscle actin genes are transcribed by nuclear isoform of mitochondrial RNA polymerase (spRNAP-IV) whereas the non-muscle actin genes are transcribed by the conventional RNA polymerase II (PolII)

  11. Human mitochondrial RNA polymerase: evaluation of the single-nucleotide-addition cycle on synthetic RNA/DNA scaffolds

  12. POLRMT can function as an origin-specific primase in mammalian mitochondria.

  13. human mitochondrial DNA polymerase has a role in autosomal dominant progressive external ophthalmoplegia

  14. POLRMT recognizes promoter elements in a sequence specific manner; TFAM induces a structural change of the promoter that is required for POLRMT-dependent promoter recognition

  15. transcription of some mRNAs in humans and rodents is mediated by a previously unknown single-polypeptide nuclear RNA polymerase (spRNAP-IV), expressed from an alternative transcript of the mitochondrial RNA polymerase gene POLRMT

  16. the MRPL12 interaction with POLRMT is likely part of a novel regulatory mechanism that coordinates mitochondrial transcription with translation

  17. Promoter-independent DNA conformation-dependent transcription required TFB2M and was suppressed by TFAM, while promoter-dependent transcription was inhibited to a lesser extent BY TFAM.

Mouse (Murine) Polymerase (RNA) Mitochondrial (DNA Directed) (POLRMT) interaction partners

  1. we present in vivo evidence that POLRMT has a key regulatory role in the replication of mammalian mtDNA and is part of a transcriptional mechanism that provides a switch between primer formation for mtDNA replication and mitochondrial gene expression.

  2. POLRMT recognizes promoter elements in a sequence specific manner; TFAM induces a structural change of the promoter that is required for POLRMT-dependent promoter recognition

POLRMT Antigen Profile

Protein Summary

This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes.

Gene names and symbols associated with POLRMT

  • RNA polymerase mitochondrial (Polrmt) antibody
  • polymerase (RNA) mitochondrial (DNA directed) L homeolog (polrmt.L) antibody
  • polymerase (RNA) mitochondrial (DNA directed) (polrmt) antibody
  • RNA polymerase mitochondrial (POLRMT) antibody
  • polymerase (RNA) mitochondrial (DNA directed) (Polrmt) antibody
  • 1110018N15Rik antibody
  • 4932416K13 antibody
  • APOLMT antibody
  • h-mtRPOL antibody
  • MTRNAP antibody
  • mtRPO antibody
  • MTRPOL antibody
  • POLRMT antibody
  • polrmt-a antibody
  • si:dkeyp-74c5.5 antibody
  • wu:fb73g10 antibody

Protein level used designations for POLRMT

DNA-directed RNA polymerase, mitochondrial , polymerase (RNA) mitochondrial (DNA directed) , mitochondrial DNA-directed RNA polymerase , mtRPOL

GENE ID SPECIES
299604 Rattus norvegicus
394312 Xenopus laevis
557066 Danio rerio
504757 Bos taurus
5442 Homo sapiens
216151 Mus musculus
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