anti-Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) Antibodies

The protein encoded by KCNN4 is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Additionally we are shipping KCNN4 Proteins (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNN4 3783 O15554
KCNN4 65206  
KCNN4 16534 O89109
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Top anti-KCNN4 Antibodies at antibodies-online.com

Showing 10 out of 87 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KCNN4 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HepG2 cell lysate Host:  Rabbit  Target Name:  KCNN4  Sample Tissue:  Human Ovary Tumor  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$319.00
Details
Cow Goat Un-conjugated IHC, IHC (p) Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IF, IHC, WB 100 μL Log in to see 16 Days
$366.77
Details
Bat Rabbit Un-conjugated IHC, IHC (p) Anti-KCNN4 antibody  ABIN1048993 IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-KCNN4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Cow Rabbit Un-conjugated IHC, IHC (p) Anti-KCNN4 antibody  ABIN1048992 IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-KCNN4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis of Jurkat cell extracts, using KCNN4 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276990 staining HepG2 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis of extracts from HepG2 cells, using KCNN4 antibody. ABIN6275200 staining HepG2 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB Anti-KCNN antibody,  Western blotting All lanes: Anti KCNN() at 0.5ug/ml WB: HUT Whole Cell Lysate at 40ug Predicted bind size: 60KD Observed bind size: 60KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB KCNN4 (KCA3.1) Polyclonal Antibody 0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti KCNN4 Polyclonal Antibody, Unconjugated (ABIN719786) at 1:200 followed by conjugation to the secondary antibody and DAB staining Lane 1: rat brain lysates Lane 2: rat heart lysates probed with Anti KCNN4 Polyclonal Antibody, Unconjugated (ABIN719786) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 50kD. Observed band size: 45kD, 50kD. 100 μL Log in to see 3 to 7 Days
$329.45
Details

Top referenced anti-KCNN4 Antibodies

  1. Human Polyclonal KCNN4 Primary Antibody for WB - ABIN948055 : Wong, Roberts, Randall: Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions? in British journal of pharmacology 2014 (PubMed)

  2. Human Polyclonal KCNN4 Primary Antibody for IF (p), IHC (p) - ABIN719786 : Zhang, Yang, Yin, Yi, Shen, Zhao, Zhu, Liu: Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells. in PLoS ONE 2016 (PubMed)

  3. Human Polyclonal KCNN4 Primary Antibody for IHC, IHC (p) - ABIN4328499 : Rabjerg, Oliván-Viguera, Hansen, Jensen, Sevelsted-Møller, Walter, Jensen, Marcussen, Köhler: High expression of KCa3.1 in patients with clear cell renal carcinoma predicts high metastatic risk and poor survival. in PLoS ONE 2015 (PubMed)

More Antibodies against KCNN4 Interaction Partners

Pig (Porcine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. Blockade of K(Ca)3.1 by delivery of TRAM-34 via balloon catheter prevented smooth muscle phenotypic modulation and limited subsequent restenosis in a swine model.

Human Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. The results of this study suggest that KCa3.1 is involved in the regulation of Ca(2+) homeostasis in astrocytes and attenuation of the UPR and ER stress, thus contributing to memory deficits and neuronal loss.

  2. These results suggest that His358, the inhibitory histidine in KCa3.1, might coordinate a copper ion through a similar binding mode.

  3. T-cell dependency on Kv1.3 or KCa3.1 might be irreversibly modulated by antigen exposure.

  4. present study was designed to evaluate in hereditary xerocytosis the functional link between mutated Piezo1 and KCNN4

  5. this study reports cryo-electron microscopy (cryo-EM) structures of a human SK4-CaM channel complex in closed and activated states at 3.4- and 3.5-angstrom resolution, respectively.

  6. Expression of intermediate-conductance calmodulin/calcium-activated K+ channels 3.1 (KCa3.1) mRNA and protein was detected in all three layers of the human cornea.

  7. KCa3.1 channels are important modulators in hepatocellular homeostasis.

  8. Tumor suppressor miR-497-5p down-regulates KCa3.1 expression and contributes to the inhibition of angiosarcoma malignancy development.

  9. We identified a two-gene signature including KCNN4 and S100A14 which was related to recurrence in optimally debulked serous ovarian carcinoma patients

  10. Human arrhythmogenic calmodulin mutations impede the activation of SK2 channels in human embryonic kidney 293 cells.

  11. This study found a very substantial functional expression of KCa3.1 channels in microglia from adult epilepsy patients.

  12. Data show that RNAi-mediated knockdown of KCa3.1 and/or TRPC1 leads to a significant decrease in cell proliferation due to cell cycle arrest in the G1 phase.

  13. Higher epithelial KCNN4 expression was closely correlated with advanced TNM stages and predicted a poor prognosis in patients with pancreatic ductal adenocarcinoma.

  14. Here, the authors demonstrate that phosphorylation of His358 activates KCa3.1 by antagonizing copper-mediated inhibition of the channel.

  15. This work demonstrates the critical role of SK4 Ca(2+)-activated K(+) channels in adult pacemaker function.

  16. Implicating both KCa1.1 and KCa3.1 channels.

  17. Blocking KCa3.1 suppresses plaque instability in advanced stages of atherosclerosis by inhibiting macrophage polarization toward an M1 phenotype.

  18. IKCa1 is overexpressed in cervical cancer tissues, and IKCa1 upregulation in cervical cancer cell linea enhances cell proliferation, partly by reducing the proportion of apoptotic cells.

  19. Findings suggest that SK4 channels are expressed in triple-negative breast cancer (TNBC) cells and are involved in the proliferation, apoptosis, migration and epithelial-mesenchymal transition processes of TNBC cells.

  20. KCa3.1 blockade protects against cisplatin-induced acute kidney injury through the attenuation of apoptosis by interference with intrinsic apoptotic and endoplasmic reticulum stress-related mediators.

Cow (Bovine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. Blood brain barrier endothelial cells exhibit KCa3.1 protein and activity.

Mouse (Murine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. KCa3.1 channel is likely to be a critical target on the oxidative stress.

  2. Diet-induced hyperhomocysteinemia enhanced myoendothelial feedback, and increased Cx37 and IK1 expression may contribute. nNOS or iNOS did not upregulate to compensate for decreased eNOS, and they had little involvement in vasomotor function.

  3. The Intermediate-conductance calmodulin/calcium-activated K+ channels 3.1 (KCa3.1-/- knockout mice) significantly reduced corneal fibrosis and expression of pro-fibrotic marker genes, suggesting that KCa3.1 plays an important role corneal wound healing in vivo.

  4. KCa3.1(-/-) mice exhibited significantly smaller infarct areas in a model of ischemic stroke.

  5. KCa3.1(-/-) mice demonstrated normal behavioral responses in models of acute nociceptive, persistent inflammatory, and persistent neuropathic pain. However, their behavioral responses to noxious chemical stimuli such as formalin and capsaicin were increased. Accordingly, formalin-induced nociceptive behavior was increased in wild-type mice after administration of the KCa3.1 inhibitor TRAM-34.

  6. SK4 activity is crucial for cell cycle control.

  7. Following differentiation with LPS or a combination of LPS and IFN-gamma microglia exhibited high KV 1.3 current densities ( approximately 50 pA/pF at 40 mV) and virtually no KCa 3.1 and Kir currents, while microglia differentiated with IL-4 exhibited large Kir 2.1 currents ( approximately 10 pA/pF at -120 mV). KCa 3.1 currents were generally low

  8. Deletion of KCa3.1 reduced astrogliosis and rescued memory loss induced by intrahippocampal Abeta1-42 peptide injection.

  9. Dynamic coupling between TRPV4 and Ca(2+)-activated SK1/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 in kidney collecting duct cells.

  10. Blocking KCa3.1 suppresses plaque instability in advanced stages of atherosclerosis by inhibiting macrophage polarization toward an M1 phenotype.

  11. enhanced KCa 3.1 activity may compensate for decreased nitric oxide signaling during vascular aging.

  12. Findings highlight a novel role for intermediate-conductance calcium-activated potassium channel (KCa3.1) in phenotypic modulation of reactive astrocytes and in astrocyte mobilization in response to mechanical stress, providing a potential target for therapeutic intervention in brain injuries.

  13. alpha1D Ca and SK4 channels are coupled in the atria, and deletion of alpha1D leads to decreased SK4 mRNA and BNP secretion providing evidence for a novel role of alpha1D in atrial endocrine function

  14. KCa3.1 blockade protects against cisplatin-induced acute kidney injury through the attenuation of apoptosis by interference with intrinsic apoptotic and endoplasmic reticulum stress-related mediators.

  15. The results suggest that KCa3.1 activation contributes to dysfunctional tubular autophagy in diabetic nephropathy through PI3K/Akt/mTOR signaling pathways.

  16. These results indicate that IK1 channels do not mediate the a slow afterhyperpolarization in pyramidal neurons.

  17. KCa3.1 is a possible marker of M/MPhi in the protumor state and a potential therapeutic target to induce glioma-associated microglia/macrophages to re-acquire a pro-inflammatory, antitumor activity.

  18. promotes B lymphocyte activation, proliferation and monocyte chemotaxis

  19. that KCa3.1 channels are key actors in the migration capacity of neutrophils, and its inhibition did not affect other relevant cellular functions

  20. Modulation of PKA and PI3KC2beta activity to control of KCa3.1 channel expression can be an alternative important target to attenuate ascending thoracic aortic aneurysms in Fabry disease.

KCNN4 Antigen Profile

Protein Summary

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.

Gene names and symbols associated with KCNN4

  • potassium calcium-activated channel subfamily N member 4 (KCNN4) antibody
  • potassium calcium-activated channel subfamily N member 4 (Kcnn4) antibody
  • potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (Kcnn4) antibody
  • hIKCa1 antibody
  • hKCa4 antibody
  • hSK4 antibody
  • IK1 antibody
  • IKCA1 antibody
  • KCa3.1 antibody
  • KCA4 antibody
  • mIKCa1 antibody
  • rKCNN4c antibody
  • rSK4 antibody
  • SK4 antibody
  • SKCas antibody

Protein level used designations for KCNN4

intermediate conductance calcium-activated potassium channel protein 4 , intermediate-conductance calcium-activated potassium channel , intermediate conductance calcium-activated potassium channel protein 1 , potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 , intermediate conductance calcium-activated potassium channel protein 4-like , SKCa 4 , SKCa4 , putative Gardos channel , putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel , IK1 , KCa4 , SK4 , intermediate conductance K channel , intermediate-conductance Ca-activated K channel , potassium intermediate-small conductance calcium-activated channel subfamily N member 4

GENE ID SPECIES
397081 Sus scrofa
456098 Pan troglodytes
100379254 Cavia porcellus
100391934 Callithrix jacchus
100468357 Ailuropoda melanoleuca
100593199 Nomascus leucogenys
3783 Homo sapiens
65206 Rattus norvegicus
534591 Bos taurus
484464 Canis lupus familiaris
16534 Mus musculus
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