anti-Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) Antibodies

The protein encoded by KCNN4 is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Additionally we are shipping KCNN4 Proteins (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNN4 3783 O15554
KCNN4 65206  
KCNN4 16534 O89109
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Top anti-KCNN4 Antibodies at antibodies-online.com

Showing 10 out of 87 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KCNN4 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HepG2 cell lysate Host:  Rabbit  Target Name:  KCNN4  Sample Tissue:  Human Ovary Tumor  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: KCNN4 Antibody [NBP2-33694] - breast cancer Immunohistochemistry: KCNN4 Antibody [NBP2-33694] - Immunohistochemical staining of human smooth muscle shows moderate cytoplasmic positivity in smooth muscle cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated IF, IHC, WB 100 μL Log in to see 16 Days
$334.02
Details
Cow Goat Un-conjugated IHC, IHC (p) Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$484.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p) Anti-KCNN4 antibody  ABIN1048993 IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Cow Rabbit Un-conjugated IHC, IHC (p) Anti-KCNN4 antibody  ABIN1048992 IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), WB   100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB Anti-KCNN antibody,  Western blotting All lanes: Anti KCNN() at 0.5ug/ml WB: HUT Whole Cell Lysate at 40ug Predicted bind size: 60KD Observed bind size: 60KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB KCNN4 (KCA3.1) Polyclonal Antibody 0.1 mg Log in to see 6 to 8 Days
$379.50
Details

KCNN4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-KCNN4 Antibodies

  1. Human Polyclonal KCNN4 Primary Antibody for WB - ABIN948055 : Wong, Roberts, Randall: Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions? in British journal of pharmacology 2014 (PubMed)

  2. Human Polyclonal KCNN4 Primary Antibody for IF (p), IHC (p) - ABIN719786 : Zhang, Yang, Yin, Yi, Shen, Zhao, Zhu, Liu: Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells. in PLoS ONE 2016 (PubMed)

  3. Human Polyclonal KCNN4 Primary Antibody for IHC, IHC (p) - ABIN4328499 : Rabjerg, Oliván-Viguera, Hansen, Jensen, Sevelsted-Møller, Walter, Jensen, Marcussen, Köhler: High expression of KCa3.1 in patients with clear cell renal carcinoma predicts high metastatic risk and poor survival. in PLoS ONE 2015 (PubMed)

More Antibodies against KCNN4 Interaction Partners

Pig (Porcine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. Blockade of K(Ca)3.1 by delivery of TRAM (show TRAM1 Antibodies)-34 via balloon catheter prevented smooth muscle phenotypic modulation and limited subsequent restenosis in a swine model.

Human Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. this study reports cryo-electron microscopy (cryo-EM) structures of a human SK4-CaM channel complex in closed and activated states at 3.4- and 3.5-angstrom resolution, respectively.

  2. Expression of intermediate-conductance calmodulin/calcium-activated K+ channels 3.1 (KCa3.1) mRNA and protein was detected in all three layers of the human cornea.

  3. KCa3.1 channels are important modulators in hepatocellular homeostasis.

  4. Tumor suppressor miR (show MLXIP Antibodies)-497-5p down-regulates KCa3.1 expression and contributes to the inhibition of angiosarcoma malignancy development.

  5. We identified a two-gene signature including KCNN4 and S100A14 (show S100A14 Antibodies) which was related to recurrence in optimally debulked serous ovarian carcinoma patients

  6. Human arrhythmogenic calmodulin mutations impede the activation of SK2 (show KCNN2 Antibodies) channels in human embryonic kidney 293 cells.

  7. This study found a very substantial functional expression of KCa3.1 channels in microglia from adult epilepsy patients.

  8. Data show that RNAi-mediated knockdown of KCa3.1 and/or TRPC1 (show TRPC1 Antibodies) leads to a significant decrease in cell proliferation due to cell cycle arrest in the G1 phase.

  9. Higher epithelial KCNN4 expression was closely correlated with advanced TNM (show ODZ1 Antibodies) stages and predicted a poor prognosis in patients with pancreatic ductal adenocarcinoma.

  10. Here, the authors demonstrate that phosphorylation of His358 activates KCa3.1 by antagonizing copper-mediated inhibition of the channel.

Cow (Bovine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. Blood brain barrier endothelial cells exhibit KCa3.1 protein and activity.

Mouse (Murine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. Diet-induced hyperhomocysteinemia enhanced myoendothelial feedback, and increased Cx37 (show GJA4 Antibodies) and IK1 expression may contribute. nNOS (show NOS1 Antibodies) or iNOS (show NOS2 Antibodies) did not upregulate to compensate for decreased eNOS (show NOS3 Antibodies), and they had little involvement in vasomotor function.

  2. The Intermediate-conductance calmodulin/calcium-activated K+ channels 3.1 (KCa3.1-/- knockout mice) significantly reduced corneal fibrosis and expression of pro-fibrotic marker genes, suggesting that KCa3.1 plays an important role corneal wound healing in vivo.

  3. KCa3.1(-/-) mice exhibited significantly smaller infarct areas in a model of ischemic stroke.

  4. KCa3.1(-/-) mice demonstrated normal behavioral responses in models of acute nociceptive, persistent inflammatory, and persistent neuropathic pain. However, their behavioral responses to noxious chemical stimuli such as formalin and capsaicin were increased. Accordingly, formalin-induced nociceptive behavior was increased in wild-type mice after administration of the KCa3.1 inhibitor TRAM (show TICAM2 Antibodies)-34.

  5. SK4 activity is crucial for cell cycle control.

  6. Following differentiation with LPS (show TLR4 Antibodies) or a combination of LPS (show TLR4 Antibodies) and IFN-gamma (show IFNG Antibodies) microglia exhibited high KV 1.3 current densities ( approximately 50 pA/pF at 40 mV) and virtually no KCa (show CSN3 Antibodies) 3.1 and Kir (show GEM Antibodies) currents, while microglia differentiated with IL-4 (show IL4 Antibodies) exhibited large Kir (show GEM Antibodies) 2.1 currents ( approximately 10 pA/pF at -120 mV). KCa (show CSN3 Antibodies) 3.1 currents were generally low

  7. Deletion of KCa3.1 reduced astrogliosis and rescued memory loss induced by intrahippocampal Abeta1-42 peptide injection.

  8. Dynamic coupling between TRPV4 (show TRPV4 Antibodies) and Ca(2 (show CA2 Antibodies)+)-activated SK1 (show SPHK1 Antibodies)/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 (show KCNMA1 Antibodies) in kidney collecting duct cells.

  9. Blocking KCa3.1 suppresses plaque instability in advanced stages of atherosclerosis by inhibiting macrophage polarization toward an M1 phenotype.

  10. enhanced KCa (show CSN3 Antibodies) 3.1 activity may compensate for decreased nitric oxide signaling during vascular aging.

KCNN4 Antigen Profile

Protein Summary

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.

Gene names and symbols associated with KCNN4

  • potassium calcium-activated channel subfamily N member 4 (KCNN4) antibody
  • potassium calcium-activated channel subfamily N member 4 (Kcnn4) antibody
  • potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (Kcnn4) antibody
  • hIKCa1 antibody
  • hKCa4 antibody
  • hSK4 antibody
  • IK1 antibody
  • IKCA1 antibody
  • KCa3.1 antibody
  • KCA4 antibody
  • mIKCa1 antibody
  • rKCNN4c antibody
  • rSK4 antibody
  • SK4 antibody
  • SKCas antibody

Protein level used designations for KCNN4

intermediate conductance calcium-activated potassium channel protein 4 , intermediate-conductance calcium-activated potassium channel , intermediate conductance calcium-activated potassium channel protein 1 , potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 , intermediate conductance calcium-activated potassium channel protein 4-like , SKCa 4 , SKCa4 , putative Gardos channel , putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel , IK1 , KCa4 , SK4 , intermediate conductance K channel , intermediate-conductance Ca-activated K channel , potassium intermediate-small conductance calcium-activated channel subfamily N member 4

GENE ID SPECIES
397081 Sus scrofa
456098 Pan troglodytes
100379254 Cavia porcellus
100391934 Callithrix jacchus
100468357 Ailuropoda melanoleuca
100593199 Nomascus leucogenys
3783 Homo sapiens
65206 Rattus norvegicus
534591 Bos taurus
484464 Canis lupus familiaris
16534 Mus musculus
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