anti-Potassium Voltage-Gated Channel, Isk-Related Family, Member 4 (KCNE4) Antibodies

Rabbit Potassium Voltage-Gated Channel, Isk-Related Family, Member 4 (KCNE4) interaction partners

1. Apparent association with BK channel in renal collecting duct

Human Potassium Voltage-Gated Channel, Isk-Related Family, Member 4 (KCNE4) interaction partners

1. Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4 has been reported.

2. The KCNE1 (rs1805127) appears to an independent risk factor for AF in the Uygur population. And the KCNE4 (rs12621643) was an independent risk factor for AF among both Uygurs and Hans.

3. Reported here are previously undiscovered protein-coding regions in exon 1 of hKCNE3 and hKCNE4 that extend their encoded extracellular domains by 44 and 51 residues, which yields full-length proteins of 147 and 221 residues, respectively.

4. the tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for Kv1.3- KCNE4 interaction.

5. the association of the KCNE4 gene variability with allergic rhinitis

6. KCNE4 juxtamembrane region is required for interaction with calmodulin and for functional suppression of KCNQ1.

7. MiRP3 modulates Kv4.2 current activation, inactivation and recovery from inactivation. MiRP3 shifts the half-maximal voltage for activation and slows time to peak ~ 100%.

8. KCNE4 E145D polymorphism may be related to atrial fibrillation.

9. KCNE4 (potassium voltage-gated channel subfamily E member 4), but not KCNE2, functions as an inhibitory Kv1.3 partner in leukocytes.

10. expressed strongly in heart, skeletal muscle, and kidney, less in placenta, lung, and liver, and weakly in brain and blood cells. Electrophysiological study showed that KCNE4 modulates the activation of the KCNQ1 channel.

11. KCNE4 beta-subunit has a drastic inhibitory effect on currents generated by Kv1.1 and Kv1.3 potassium channels

12. Based upon previous studies and the present results, it is concluded that both hKCNE4 and mKCNE4 have a drastic inhibitory impact on both hKCNQ1 and mKCNQ1 currents.

13. The non-synonymous single nucleotide polymorphism E145D may be associated with the atrial fibrillation phenotype.

14. KCNE4 directly associates with KCNQ1, and can co-associate together with KCNE1 in the same KCNQ1 complex to form a 'triple subunit' complex (KCNE1-KCNQ1-KCNE4).

15. MiRP3 (encoded by the KCNE4 gene) plays a role in modulation of BK-dependent urinary potassium excretion.

16. Specific KCNE4 domains responsible for the inhibitory effects on heterologously expressed KCNQ1 were identified. The KCNE4 C-terminus is critical for KCNQ1 modulation and physically interacts with KCNQ1.

Mouse (Murine) Potassium Voltage-Gated Channel, Isk-Related Family, Member 4 (KCNE4) interaction partners

1. the tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for Kv1.3- KCNE4 interaction.

2. Suggest role for KCNE4 in regulation of Kv7 channel activity to modulate vascular tone, and provide the first known molecular mechanism for sex-specificity of this modulation.

3. Kcne4 expression and function are age-, sex- dependent and regulated by 5alpha-dihydrotestosterone.

4. KCNE4 (potassium voltage-gated channel subfamily E member 4), but not KCNE2, functions as an inhibitory Kv1.3 partner in leukocytes.

5. KCNE4 beta-subunit has a drastic inhibitory effect on currents generated by Kv1.1 and Kv1.3 potassium channels

6. Based upon previous studies and the present results, it is concluded that both hKCNE4 and mKCNE4 have a drastic inhibitory impact on both hKCNQ1 and mKCNQ1 currents.