anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) Antibodies

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. Additionally we are shipping Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNQ2 3785 O43526
KCNQ2 16536 Q9Z351
KCNQ2 170848 O88943
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Top anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Antibodies at antibodies-online.com

Showing 10 out of 106 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-KCNQ2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Jurkat cell lysate Immunohistochemistry with Brain, cortex tissue at an antibody concentration of 5µg/ml using anti-KCNQ2 antibody (ARP35458_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-KCNQ2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  NCI-H226 cell lysate There is BioGPS gene expression data showing that KCNQ2 is expressed in NCIH226 Immunohistochemistry with Brain, cerebellum tissue at an antibody concentration of 5µg/ml using anti-KCNQ2 antibody (ARP35457_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KCNQ2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Kcnq2 Antibody   Titration: 1.0 ug/ml   Positive Control: Mouse Brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Hamster Mouse FITC AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Tissue: frozen brain section. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human, hamster HEK and CHO cell lysates showing detection of KCNQ2 protein using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. KCNQ2 overexpressed. 100 μg Log in to see 3 to 4 Days
$504.40
Details
Hamster Mouse PerCP AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Tissue: frozen brain section. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human, hamster HEK and CHO cell lysates showing detection of KCNQ2 protein using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. KCNQ2 overexpressed. 100 μg Log in to see 3 to 4 Days
$513.50
Details
Hamster Mouse APC AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Tissue: frozen brain section. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human, hamster HEK and CHO cell lysates showing detection of KCNQ2 protein using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. KCNQ2 overexpressed. 100 μg Log in to see 3 to 4 Days
$513.50
Details
Hamster Mouse Atto 655 AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Tissue: frozen brain section. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human, hamster HEK and CHO cell lysates showing detection of KCNQ2 protein using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. KCNQ2 overexpressed. 100 μg Log in to see 3 to 4 Days
$514.80
Details
Hamster Mouse Atto 700 AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Tissue: frozen brain section. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human, hamster HEK and CHO cell lysates showing detection of KCNQ2 protein using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. KCNQ2 overexpressed. 100 μg Log in to see 3 to 4 Days
$514.80
Details
Hamster Mouse Atto 633 AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Tissue: frozen brain section. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human, hamster HEK and CHO cell lysates showing detection of KCNQ2 protein using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. KCNQ2 overexpressed. 100 μg Log in to see 3 to 4 Days
$514.80
Details

Top referenced anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Antibodies

  1. Mammalian Monoclonal KCNQ2 Primary Antibody for ISt, IHC - ABIN1304776 : Miceli, Soldovieri, Ambrosino, De Maria, Migliore, Migliore, Taglialatela: Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 (PubMed)
    Show all 12 Pubmed References

  2. Cow (Bovine) Polyclonal KCNQ2 Primary Antibody for IHC, WB - ABIN2776304 : Tang, Li, Xia, Jiang, Pan, Shen, Long, Zhao, Cai: A novel mutation in KCNQ2 gene causes benign familial neonatal convulsions in a Chinese family. in Journal of the neurological sciences 2004 (PubMed)
    Show all 3 Pubmed References

More Antibodies against Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Interaction Partners

Human Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) interaction partners

  1. This study provides evidence that neurotransmitter-induced suppression of M-current generated by Kv7.2-containing channels exacerbates behavioral seizures.

  2. An optimum cholesterol level in the plasma membrane is required for the proper functioning of Kv7.2/Kv7.3 channels.

  3. Study describes the interactions of hposphatidylinositol-4,5-bisphosphate with both the open and closed states of a KCNQ2 channel. Through these methods, results show that a lipid can migrate between different binding sites in a protein and this migration modulates protein functions.

  4. A distinctive ictal amplitude-integrated EEG pattern occurs in newborns with neonatal epilepsy associated with KCNQ2 mutations.

  5. patients with the KCNQ2 E515D mutation are susceptible to seizures.

  6. he present study involves identification of newer anti-epileptic agents by means of a computer-aided drug design adaptive protocol involving both structure-based virtual screening of Asinex library using homology model of KCNQ2 and 3D-QSAR based virtual screening with docking analysis, followed by dG bind and ligand efficiency calculations with ADMET studies, of which 20 hits qualified all the criterions.

  7. This study provided evidence to suggests that the p.R213Q mutation has a dominant-negative effect on the current amplitude of homomeric wild-type and mutant KCNQ2 constructs, which correlates with clinical seizure frequencies and neurodevelopmental outcomes.

  8. Mutations in STXBP1 encoding the syntaxin binding protein 1 can produce a phenotype similar to that of KCNQ2 mutations

  9. whole exome sequencing in families with ID and history of autosomal dominant inheritance pattern with or without seizures, may further broaden the phenotypic spectrum of KCNQ2 associated epileptic encephalopathy or encephalopathy

  10. The direct effect of heat on KCNQ2 channels may be involved in excitability regulation of neurons, and the P-loop region is critical for temperature-dependent modulation of the expression and trafficking of KCNQ2 channels.

  11. Epileptic encephalopathy with burst suppression without brain malformations is associated with pathogenic variation in KCNQ2.

  12. Heterozygous KCNQ2 R201C and R201H gain-of-function variants present with profound neonatal encephalopathy in the absence of neonatal seizures.

  13. This study provide evidence for a new phenotypic and functional profile in KCNQ2-related epilepsy.

  14. In the present work, a pharmacophore-based 3D-QSAR model was generated for a series of N-pyridyl and pyrimidine benzamides possessing KCNQ2/Q3 opening activity. The pharmacophore model generated contains one hydrogen bond donor (D), one hydrophobic (H), and two aromatic rings (R). They are the crucial molecular write-up detailing predicted binding efficacy of high affinity and low affinity ligands for KCNQ2/Q3 opening a

  15. This study demonstrated that Mutations in the KCNQ2 gene encoding the voltage-gated potassium channel subunit Kv7.2 cause early onset epileptic encephalopathy .

  16. This work shows for the first time the association between KCNQ2 mutations and startle attacks in 38% of patients, which opens the possibility to define electroclinical phenotypes associated to KCNQ2 mutations. It also demonstrates that KCNQ2 mutations contribute to an important percentage of Spanish patients with epilepsy.

  17. USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation.

  18. a structural mechanism for the gating of the Kv7.3 PM and for the site of action of RTG as a Kv7.2/Kv7.3 K(+) current activator.

  19. There is a variable clinical expression in infantile epilepsy patients with mosaicism for KCNQ2 mutations.

  20. Our data indicate that the TW site is dispensable for function, contributes to the stabilization of the CaM-Kv7.2 complex and becomes essential when docking to either helix A or when helix B is perturbed.

Mouse (Murine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) interaction partners

  1. decreases in interneuron KCNQ2/3 activity remodels excitatory networks, providing a new function for these channels.

  2. The data of this study showed that, in Kcnq2 mutant slices, burst activity was modulated by GABAA receptor blockade.

  3. Kcnq2 ablation leads to increased neuronal excitability of neocortex layer 2/3 pyramidal neurons.

  4. USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation.

  5. Mechanosensitivity of Skin Down-hair mechanoeceptors is increased in Kcnq3-/- and in Kcnq2+/-/Kcnq3-/- Mutant Mice.

  6. Resilience to tinnitus is developed in mice that show a re-emergence of KCNQ2/3 channel activity and a reduction in HCN channel activity.

  7. Reduced M-current in the superior cervical ganglion neurons of Kcnq2 truncation mutation heterozygotic mice.

  8. Data show that a reduction in Kv7.2/3 channel activity is essential for tinnitus induction and for the tinnitus-specific hyperactivity.

  9. Retigabine is more effective on KCNQ3 than KCNQ2, whereas ZnPy is more effective on KCNQ2 with no detectable effect on KCNQ3.

  10. Results show that in the same protein complex in which PKA augments L currents, AKAP79/150 directs calcineurin to activate NFAT and initiate a longer-term feedback loop that upregulates M-channel expression, countering increased neuronal excitability.

  11. Accumulation of Kv7 channels in afferent fibers may increase M-type currents which then acquired a more important role at regulating fiber excitability.

  12. Data show that in early pregnant mouse myometrium, the relative abundance of mRNA expression was KCNQ3 > KCNQ4 > KCNQ5 > KCNQ1 > KCNQ2.

  13. These findings provide novel evidence that KCNQ2/3 channels could be an important regulator in neuronal apoptosis.

  14. These findings demonstrate that spectrin cytoskeleton finely regulates ion channel distribution and implicates KCNQ2/3 subunits in axonal excitability and in myokymia etiology.

  15. Suppression of neuronal KCNQ2 current in mice is associated with spontaneous seizures, behavioral hyperactivity and morphological changes in hippocampus.

  16. Genomic deletions affecting the C terminus of KCNQ2 have been identified in human families with benign familial neonatal convulsions.

  17. In the adult mouse brain, a predominantly axonal staining pattern was found, most observed in the caudoputamen, the alveus and the mossy fiber pathway of the hippocampus. The hippocampal staining pattern of adult mice was not observed before P8.

  18. This study evaluated a model of benign familial neonatal convulsions in transgenic mice with a knockin mutation for KCNQ2 and KCNQ3 mutations.

  19. expression of Kcnq2 is in the modiolus and organ of Corti, while Kcnq3 expression was also detected in the cochlear lateral wall and both in spiral ganglion neurons

  20. KCNQ2 and KCNQ3 channels contribute to the apamin-insensitive afterhyperpolarization.

Horse (Equine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) interaction partners

  1. The KCNQ2 and KCNQ3 genes are located on the terminal region of chromosomes 22 and 9, respectively. The KCNQ2 gene tree exhibited close clustering between horses and humans, relative to horses and mice.

Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) Antigen Profile

Protein Summary

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.

Gene names and symbols associated with KCNQ2

  • potassium voltage-gated channel subfamily Q member 2 (KCNQ2) antibody
  • potassium voltage-gated channel, subfamily Q, member 2 (Kcnq2) antibody
  • potassium voltage-gated channel subfamily Q member 2 (Kcnq2) antibody
  • potassium voltage-gated channel subfamily KQT member 2 (LOC100537363) antibody
  • potassium voltage-gated channel, KQT-like subfamily, member 2a (kcnq2a) antibody
  • BFNC antibody
  • BFNS1 antibody
  • EBN antibody
  • EBN1 antibody
  • EIEE7 antibody
  • ENB1 antibody
  • HNSPC antibody
  • KCNA11 antibody
  • KQT2 antibody
  • KV7.2 antibody
  • KVEBN1 antibody
  • mKQT2.3 antibody
  • mKQT2.4 antibody
  • Nmf134 antibody
  • zgc:171872 antibody

Protein level used designations for KCNQ2

KQT-like 2 , neuroblastoma-specific potassium channel protein , neuroblastoma-specific potassium channel subunit alpha KvLQT2 , potassium voltage-gated channel subfamily KQT member 2 , voltage-gated potassium channel subunit Kv7.2 , potassium channel subunit alpha KvLQT2 , potassium voltage-gated channel, subfamily Q, member 2 , potassium voltage-gated channel KQT-like subfamily member 2.3 , potassium voltage-gated channel KQT-like subfamily member 2.4 , potassium voltage-gated channel, KQT-like subfamily, member 2 , LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily KQT member 2 , uncharacterized protein LOC100141342

GENE ID SPECIES
3785 Homo sapiens
16536 Mus musculus
170848 Rattus norvegicus
100537363 Danio rerio
428151 Gallus gallus
100146986 Equus caballus
505963 Bos taurus
612515 Canis lupus familiaris
100732168 Cavia porcellus
101118630 Ovis aries musimon
100141342 Danio rerio
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