KCNQ2 antibody (Middle Region)

Catalog No. ABIN2776304

This Rabbit Polyclonal antibody specifically detects KCNQ2 in WB and IHC. It exhibits reactivity toward Rat, Human, Mouse, Dog, Cow, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio). It has been mentioned in 2+ publications

Quick Overview for KCNQ2 antibody (Middle Region) (ABIN2776304)

Target: KCNQ2 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2))

Reactivity: Rat, Human, Mouse, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNQ2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-KCNQ2 Antibody

Binding Specificity: Middle Region

Sequence: GNVFATSALR SLRFLQILRM IRMDRRGGTW KLLGSVVYAH SKELVTAWYI

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against KCNQ2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KCNQ2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 393 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-KCNQ2 antibody (ABIN2776304)

Zhang, Liu, Xu, Zhang, Liang, Du, Zhang: "Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents." in: Neuroscience, Vol. 254, pp. 70-9, (2013) (PubMed).

Tang, Li, Xia, Jiang, Pan, Shen, Long, Zhao, Cai: "A novel mutation in KCNQ2 gene causes benign familial neonatal convulsions in a Chinese family." in: Journal of the neurological sciences, Vol. 221, Issue 1-2, pp. 31-4, (2004) (PubMed).

Target Details for KCNQ2

Target: KCNQ2 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2))

Alternative Name: KCNQ2

Background: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by the KCNQ2 gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1).
Alias Symbols: EBN, BFNC, EBN1, ENB1, BFNS1, EIEE7, HNSPC, KV7.2, KCNA11, KVEBN1
Protein Interaction Partner: ARIH2, KCNQ3, PRKCA, CALM3, CALM1, CALM2, KCNQ1,
Protein Size: 393

Molecular Weight: 43 kDa

Gene ID: 3785

NCBI Accession: NM_172109, NP_742107

UniProt: Q5VYU0