anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) Antibodies

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping KCNA3 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNA3 3738 P22001
KCNA3 16491 P16390
KCNA3 29731 P15384
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Top anti-KCNA3 Antibodies at antibodies-online.com

Showing 10 out of 117 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$461.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of KCNA3 Antibody (Center) in A549 cell line lysates (35ug/lane).This demonstrates the KCNA3 antibody detected the KCNA3 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chicken Rabbit Un-conjugated IP, WB Western blot analysis of Kv1.3 expression in A549 (A) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Chicken Rabbit Un-conjugated WB Western blot analysis of Kv1.3 (pY187) expression in HEK293T EGF-treated (A), SP2/0 EGF-treated (B), PC12 EGF-treated (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$575.00
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells treated with starved 24h, using Kv1.3/KCNA3 (Phospho-Tyr135) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain, using Kv1.3/KCNA3 (Phospho-Tyr135) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Mammalian Mouse Un-conjugated ISt, IHC, WB   5 mL Log in to see 2 to 6 Days
$366.67
Details
Human Rabbit Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Kv1.3/KCNA3 (Ab-135) Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HuvEc cells, using Kv1.3/KCNA3 (Ab-135) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB 100 μL Log in to see 16 Days
$181.73
Details

Top referenced anti-KCNA3 Antibodies

  1. Mammalian Monoclonal KCNA3 Primary Antibody for ISt, IHC - ABIN1304749 : Cidad, Novensà, Garabito, Batlle, Dantas, Heras, López-López, Pérez-García, Roqué: K+ channels expression in hypertension after arterial injury, and effect of selective Kv1.3 blockade with PAP-1 on intimal hyperplasia formation. in Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2014 (PubMed)
    Show all 21 Pubmed References

More Antibodies against KCNA3 Interaction Partners

Human Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) interaction partners

  1. In this work, we showed that although both Kv1.1 (show KCNA1 Antibodies) and Kv1.3 channels are expressed in U87 (glioblastoma), MDA-MB-231 (breast cancer) and LS174 (colon adenocarcinoma) cells, these respond differently to KAaH1 or KAaH2, two homologous Kv1 (show KCNA5 Antibodies) blockers from scorpion venom

  2. Kv1.3 methylation may serve as diagnostic and prognostic markers in colorectal cancer.

  3. the tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for Kv1.3- KCNE4 (show KCNE4 Antibodies) interaction.

  4. results identify a caveolin-binding domain in Kv1 (show KCNA5 Antibodies) channels and highlight the mechanisms that govern the regulation of channel surface localization during cellular processes

  5. we report that Kv1.3-NPs (show NPS Antibodies) reduced NFAT (show NFATC1 Antibodies) activation and CD40L (show CD40LG Antibodies) expression exclusively in CD45RO(+) T cells. Furthermore, Kv1.3-NPs (show NPS Antibodies) suppressed cytokine release and induced a phenotype switch of T cells from predominantly memory to naive.

  6. The implication of Kv1.3 in a wide repertoire of human pathologies indicates this channel is an important therapeutic target.

  7. Results contribute to the characterization of leukemic B cells, as it shows that upregulation of Kv1.3 in pathologic B lymphocytes is linked to the oncogenic B-RAF (show SNRPE Antibodies) signaling.

  8. Data suggest that C-terminus is necessary for Kv1.3-induced cell proliferation; the mechanism involves accessibility of key docking sites at the C terminus; phosphorylation of Tyr (show TYR Antibodies)-447 by MAP kinase (show MAPK1 Antibodies) signal cascade appears crucial.

  9. concluded that Kv1.3 may stimulate macrophage migration through the activation of ERK (show EPHB2 Antibodies).

  10. The inhibition of Kv1.3 channels might be involved in antiproliferative and proapoptotic effects of the compounds observed in cancer cell lines expressing these channels.

Mouse (Murine) Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) interaction partners

  1. Our data shed light on the putative role of Kv1.3 in weight gain and insulin (show INS Antibodies)-dependent responses contributing to knowledge about adipocyte physiology

  2. Data show that cereblon (CRBN (show CRBN Antibodies)) limits CD4 (show CD4 Antibodies)(+) T-cell activation via epigenetic regulation of Kv1.3 potassium channel (show KCNAB2 Antibodies) (Kv1.3) expression.

  3. Following differentiation with LPS (show TLR4 Antibodies) or a combination of LPS (show TLR4 Antibodies) and IFN-gamma (show IFNG Antibodies) microglia exhibited high KV 1.3 current densities ( approximately 50 pA/pF at 40 mV) and virtually no KCa (show CSN3 Antibodies) 3.1 and Kir (show GEM Antibodies) currents, while microglia differentiated with IL-4 (show IL4 Antibodies) exhibited large Kir (show GEM Antibodies) 2.1 currents ( approximately 10 pA/pF at -120 mV). KCa (show CSN3 Antibodies) 3.1 currents were generally low

  4. These studies reveal unexpected roles of Kv1.3 subunit-containing channels in the regulation of firing patterns of striatal cholinergic interneurons, which were thought to be largely dependent on KCa (show CSN3 Antibodies) channels.

  5. the tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for Kv1.3- KCNE4 (show KCNE4 Antibodies) interaction.

  6. promotes B lymphocyte (show AKAP17A Antibodies) activation, proliferation and monocyte chemotaxis

  7. Changes in Kv1.3 subcellular distribution upon EGFR (show EGFR Antibodies) activation were due to Kv1.3 clathrin-dependent endocytosis, which targets the Kv1.3 channels to the lysosomal degradative pathway.

  8. Kv1.3 channel serves as a negative regulator of phagocytosis in macrophages and can be a potential target in the treatment of macrophage dysfunction

  9. concluded that Kv1.3 may stimulate macrophage migration through the activation of ERK (show EPHB2 Antibodies).

  10. A compensatory upregulation of the potassium channels K2P3.1 (show KCNK3 Antibodies) and KV1.3 seems to counterbalance the deletion of K2P5.1 (show KCNK5 Antibodies).

KCNA3 Antigen Profile

Protein Summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.

Gene names and symbols associated with KCNA3

  • potassium voltage-gated channel subfamily A member 3 (KCNA3) antibody
  • potassium channel, voltage gated shaker related subfamily A, member 3 S homeolog (kcna3.S) antibody
  • potassium voltage-gated channel, shaker-related subfamily, member 3 (Kcna3) antibody
  • potassium voltage-gated channel subfamily A member 3 (Kcna3) antibody
  • cKv1.1 antibody
  • HGK5 antibody
  • HLK3 antibody
  • HPCN3 antibody
  • HUKIII antibody
  • Kca1-3 antibody
  • kcna3b-a antibody
  • Kv1.3 antibody
  • Kv1.3-glyb antibody
  • Kv1.3B antibody
  • Mk-3 antibody
  • MK3 antibody
  • PCN3 antibody

Protein level used designations for KCNA3

glibenclamide-sensitive voltage-gated potassium channel , potassium voltage-gated channel subfamily A member 3 , potassium voltage-gated channel, shaker-related subfamily, member 3 , shaker-like potassium channel subunit Kv1.3B , potassium channel 3 , type n potassium channel , voltage-gated K(+) channel HuKIII , voltage-gated potassium channel protein Kv1.3 , voltage-gated potassium channel subunit Kv1.3 , MK3 , Voltage-gated potassium channel protein Kv1.3 (RGK5) (RCK3) (KV3) , potassium voltage gated channel, shaker related subfamily, member 3 , KV3 , RCK3 , RGK5 , voltage-gated potassium channel subunit Kv3 , Shaker-like voltage-gated potassium channel cKv1.1 , shaker subfamily potassium channel Kv1.3 alpha subunit , voltage-gated Kv1.3 potassium channel

GENE ID SPECIES
100328945 Oryctolagus cuniculus
373847 Xenopus laevis
3738 Homo sapiens
16491 Mus musculus
29731 Rattus norvegicus
404303 Gallus gallus
525507 Bos taurus
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