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Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping KCNA3 Proteins (5) and many more products for this protein.
Showing 10 out of 120 products:
Mammalian Monoclonal KCNA3 Primary Antibody for ISt, IHC - ABIN1304749
Cidad, Novensà, Garabito, Batlle, Dantas, Heras, López-López, Pérez-García, Roqué: K+ channels expression in hypertension after arterial injury, and effect of selective Kv1.3 blockade with PAP-1 on intimal hyperplasia formation. in Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2014
Show all 21 Pubmed References
In this work, we showed that although both Kv1.1 (show KCNA1 Antibodies) and Kv1.3 channels are expressed in U87 (glioblastoma), MDA-MB-231 (breast cancer) and LS174 (colon adenocarcinoma) cells, these respond differently to KAaH1 or KAaH2, two homologous Kv1 (show KCNA5 Antibodies) blockers from scorpion venom
Kv1.3 methylation may serve as diagnostic and prognostic markers in colorectal cancer.
the tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for Kv1.3- KCNE4 (show KCNE4 Antibodies) interaction.
results identify a caveolin-binding domain in Kv1 (show KCNA5 Antibodies) channels and highlight the mechanisms that govern the regulation of channel surface localization during cellular processes
we report that Kv1.3-NPs (show NPS Antibodies) reduced NFAT (show NFATC1 Antibodies) activation and CD40L (show CD40LG Antibodies) expression exclusively in CD45RO(+) T cells. Furthermore, Kv1.3-NPs (show NPS Antibodies) suppressed cytokine release and induced a phenotype switch of T cells from predominantly memory to naive.
The implication of Kv1.3 in a wide repertoire of human pathologies indicates this channel is an important therapeutic target.
Results contribute to the characterization of leukemic B cells, as it shows that upregulation of Kv1.3 in pathologic B lymphocytes is linked to the oncogenic B-RAF (show SNRPE Antibodies) signaling.
Data suggest that C-terminus is necessary for Kv1.3-induced cell proliferation; the mechanism involves accessibility of key docking sites at the C terminus; phosphorylation of Tyr (show TYR Antibodies)-447 by MAP kinase (show MAPK1 Antibodies) signal cascade appears crucial.
concluded that Kv1.3 may stimulate macrophage migration through the activation of ERK (show EPHB2 Antibodies).
The inhibition of Kv1.3 channels might be involved in antiproliferative and proapoptotic effects of the compounds observed in cancer cell lines expressing these channels.
Data show that cereblon (CRBN (show CRBN Antibodies)) limits CD4 (show CD4 Antibodies)(+) T-cell activation via epigenetic regulation of Kv1.3 potassium channel (show KCNAB2 Antibodies) (Kv1.3) expression.
Following differentiation with LPS (show TLR4 Antibodies) or a combination of LPS (show TLR4 Antibodies) and IFN-gamma (show IFNG Antibodies) microglia exhibited high KV 1.3 current densities ( approximately 50 pA/pF at 40 mV) and virtually no KCa (show CSN3 Antibodies) 3.1 and Kir (show GEM Antibodies) currents, while microglia differentiated with IL-4 (show IL4 Antibodies) exhibited large Kir (show GEM Antibodies) 2.1 currents ( approximately 10 pA/pF at -120 mV). KCa (show CSN3 Antibodies) 3.1 currents were generally low
These studies reveal unexpected roles of Kv1.3 subunit-containing channels in the regulation of firing patterns of striatal cholinergic interneurons, which were thought to be largely dependent on KCa (show CSN3 Antibodies) channels.
promotes B lymphocyte (show AKAP17A Antibodies) activation, proliferation and monocyte chemotaxis
Changes in Kv1.3 subcellular distribution upon EGFR (show EGFR Antibodies) activation were due to Kv1.3 clathrin-dependent endocytosis, which targets the Kv1.3 channels to the lysosomal degradative pathway.
Kv1.3 channel serves as a negative regulator of phagocytosis in macrophages and can be a potential target in the treatment of macrophage dysfunction
A compensatory upregulation of the potassium channels K2P3.1 (show KCNK3 Antibodies) and KV1.3 seems to counterbalance the deletion of K2P5.1 (show KCNK5 Antibodies).
JAK2 (show JAK2 Antibodies) participates in the signalling, regulating the voltage-gated K(+) channel (show KCND3 Antibodies) KCNA3.
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.
glibenclamide-sensitive voltage-gated potassium channel
, potassium voltage-gated channel subfamily A member 3
, potassium voltage-gated channel, shaker-related subfamily, member 3
, shaker-like potassium channel subunit Kv1.3B
, potassium channel 3
, type n potassium channel
, voltage-gated K(+) channel HuKIII
, voltage-gated potassium channel protein Kv1.3
, voltage-gated potassium channel subunit Kv1.3
, Voltage-gated potassium channel protein Kv1.3 (RGK5) (RCK3) (KV3)
, potassium voltage gated channel, shaker related subfamily, member 3
, voltage-gated potassium channel subunit Kv3
, Shaker-like voltage-gated potassium channel cKv1.1
, shaker subfamily potassium channel Kv1.3 alpha subunit
, voltage-gated Kv1.3 potassium channel