anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) Antibodies

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping KCNA3 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNA3 3738 P22001
KCNA3 16491 P16390
KCNA3 29731 P15384
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-KCNA3 Antibodies at antibodies-online.com

Showing 10 out of 120 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of KCNA3 Antibody (Center) in A549 cell line lysates (35ug/lane).This demonstrates the KCNA3 antibody detected the KCNA3 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Chicken Rabbit Un-conjugated IP, WB Western blot analysis of Kv1.3 expression in A549 (A) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Chicken Rabbit Un-conjugated WB Western blot analysis of Kv1.3 (pY187) expression in HEK293T EGF-treated (A), SP2/0 EGF-treated (B), PC12 EGF-treated (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$575.00
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells treated with starved 24h, using Kv1.3/KCNA3 (Phospho-Tyr135) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain, using Kv1.3/KCNA3 (Phospho-Tyr135) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Mammalian Mouse Un-conjugated ISt, IHC, WB   5 mL Log in to see 2 to 6 Days
$366.67
Details
Human Rabbit Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$467.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Kv1.3/KCNA3 (Ab-135) Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HuvEc cells, using Kv1.3/KCNA3 (Ab-135) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB 100 μL Log in to see 16 Days
$181.73
Details

Top referenced anti-KCNA3 Antibodies

  1. Mammalian Monoclonal KCNA3 Primary Antibody for ISt, IHC - ABIN1304749 : Cidad, Novensà, Garabito, Batlle, Dantas, Heras, López-López, Pérez-García, Roqué: K+ channels expression in hypertension after arterial injury, and effect of selective Kv1.3 blockade with PAP-1 on intimal hyperplasia formation. in Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2014 (PubMed)
    Show all 21 Pubmed References

  2. Human Polyclonal KCNA3 Primary Antibody for WB - ABIN538243 : Butenschön, Möller, Hänsel: Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3. in Journal of medicinal chemistry 2001 (PubMed)
    Show all 3 Pubmed References

More Antibodies against KCNA3 Interaction Partners

Human Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) interaction partners

  1. T-cell dependency on Kv1.3 or KCa3.1 might be irreversibly modulated by antigen exposure.

  2. In this work, we showed that although both Kv1.1 and Kv1.3 channels are expressed in U87 (glioblastoma), MDA-MB-231 (breast cancer) and LS174 (colon adenocarcinoma) cells, these respond differently to KAaH1 or KAaH2, two homologous Kv1 blockers from scorpion venom

  3. Kv1.3 methylation may serve as diagnostic and prognostic markers in colorectal cancer.

  4. the tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for Kv1.3- KCNE4 interaction.

  5. results identify a caveolin-binding domain in Kv1 channels and highlight the mechanisms that govern the regulation of channel surface localization during cellular processes

  6. we report that Kv1.3-NPs reduced NFAT activation and CD40L expression exclusively in CD45RO(+) T cells. Furthermore, Kv1.3-NPs suppressed cytokine release and induced a phenotype switch of T cells from predominantly memory to naive.

  7. The implication of Kv1.3 in a wide repertoire of human pathologies indicates this channel is an important therapeutic target.

  8. Results contribute to the characterization of leukemic B cells, as it shows that upregulation of Kv1.3 in pathologic B lymphocytes is linked to the oncogenic B-RAF signaling.

  9. Data suggest that C-terminus is necessary for Kv1.3-induced cell proliferation; the mechanism involves accessibility of key docking sites at the C terminus; phosphorylation of Tyr-447 by MAP kinase signal cascade appears crucial.

  10. concluded that Kv1.3 may stimulate macrophage migration through the activation of ERK.

  11. The inhibition of Kv1.3 channels might be involved in antiproliferative and proapoptotic effects of the compounds observed in cancer cell lines expressing these channels.

  12. Kv1.3 channels modulate human vascular smooth muscle cells proliferation independently of mTOR signaling pathway.

  13. actin dynamics regulates the membrane motility of Kv1.3 channels.

  14. The increment and decrement of the basic residue number in a positively charged S4 sensor of Kv1.3 channel yields conductance-voltage relationship curves in the positive direction by approximately 31.2 mV and 2-4 mV

  15. the association between Kv1.3 and the COPII cargo adaptor subunit isoform Sec24a

  16. Findings reveal that alpha-defensins are endogenous inhibitors of potassium voltage-gated channel subfamily A member 3 (Kv1.3) with distinct interaction mechanisms.

  17. JAK2 participates in the signalling, regulating the voltage-gated K(+) channel KCNA3.

  18. This study demonstrated that Potassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease.

  19. These results demonstrate that Kv1.3 channels are primarily localized in the nucleus of several types of cancer cells and human brain tissues where they are capable of regulating nuclear membrane potential and activation of transcription factors

  20. the small molecule Kv1.3 blocker PAP-1 dose-dependently inhibited proliferation and suppressed IL-2 and IFN-gamma production.

Mouse (Murine) Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) interaction partners

  1. Our data shed light on the putative role of Kv1.3 in weight gain and insulin-dependent responses contributing to knowledge about adipocyte physiology

  2. Data show that cereblon (CRBN) limits CD4(+) T-cell activation via epigenetic regulation of Kv1.3 potassium channel (Kv1.3) expression.

  3. Following differentiation with LPS or a combination of LPS and IFN-gamma microglia exhibited high KV 1.3 current densities ( approximately 50 pA/pF at 40 mV) and virtually no KCa 3.1 and Kir currents, while microglia differentiated with IL-4 exhibited large Kir 2.1 currents ( approximately 10 pA/pF at -120 mV). KCa 3.1 currents were generally low

  4. These studies reveal unexpected roles of Kv1.3 subunit-containing channels in the regulation of firing patterns of striatal cholinergic interneurons, which were thought to be largely dependent on KCa channels.

  5. the tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for Kv1.3- KCNE4 interaction.

  6. promotes B lymphocyte activation, proliferation and monocyte chemotaxis

  7. Changes in Kv1.3 subcellular distribution upon EGFR activation were due to Kv1.3 clathrin-dependent endocytosis, which targets the Kv1.3 channels to the lysosomal degradative pathway.

  8. Kv1.3 channel serves as a negative regulator of phagocytosis in macrophages and can be a potential target in the treatment of macrophage dysfunction

  9. concluded that Kv1.3 may stimulate macrophage migration through the activation of ERK.

  10. A compensatory upregulation of the potassium channels K2P3.1 and KV1.3 seems to counterbalance the deletion of K2P5.1.

  11. JAK2 participates in the signalling, regulating the voltage-gated K(+) channel KCNA3.

  12. Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3-Independent T Cells with Suppressive Properties

  13. A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation

  14. Our studies suggest thatKv1.3 plays a unique role in neuronal differentiation and/or survival of interneuron populations of the cerebral cortex

  15. Inhibition of NMDAR antagonists on the conductivity of Kv1.3 and KCa3.1 potassium channels was found.

  16. A significant increase of Kv1.3 protein levels was observed after LPS challenge, an effect that was blunted by e-LXA4. Kv1.3 is required for the attenuation of NF-kappaB activity.

  17. Results indicate the potential use of Kv1.3 blockers for the treatment of obesity and insulin resistance.

  18. Exert inhibitory effects on thymocyte Kv1.3-channel currents.

  19. Data indicate that ShK-K amide retained a high affinity for the voltage-gated potassium channel Kv1.3 channels (IC50 26 +/- 3 pM).

  20. findings suggest that pathways activated in Kv1.3-/- that increased energy expenditure and led to resistance to DIO are olfactory bulb dependent

KCNA3 Antigen Profile

Protein Summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.

Gene names and symbols associated with KCNA3

  • potassium voltage-gated channel subfamily A member 3 (KCNA3) antibody
  • potassium channel, voltage gated shaker related subfamily A, member 3 S homeolog (kcna3.S) antibody
  • potassium voltage-gated channel, shaker-related subfamily, member 3 (Kcna3) antibody
  • potassium voltage-gated channel subfamily A member 3 (Kcna3) antibody
  • cKv1.1 antibody
  • HGK5 antibody
  • HLK3 antibody
  • HPCN3 antibody
  • HUKIII antibody
  • Kca1-3 antibody
  • kcna3b-a antibody
  • Kv1.3 antibody
  • Kv1.3-glyb antibody
  • Kv1.3B antibody
  • Mk-3 antibody
  • MK3 antibody
  • PCN3 antibody

Protein level used designations for KCNA3

glibenclamide-sensitive voltage-gated potassium channel , potassium voltage-gated channel subfamily A member 3 , potassium voltage-gated channel, shaker-related subfamily, member 3 , shaker-like potassium channel subunit Kv1.3B , potassium channel 3 , type n potassium channel , voltage-gated K(+) channel HuKIII , voltage-gated potassium channel protein Kv1.3 , voltage-gated potassium channel subunit Kv1.3 , MK3 , Voltage-gated potassium channel protein Kv1.3 (RGK5) (RCK3) (KV3) , potassium voltage gated channel, shaker related subfamily, member 3 , KV3 , RCK3 , RGK5 , voltage-gated potassium channel subunit Kv3 , Shaker-like voltage-gated potassium channel cKv1.1 , shaker subfamily potassium channel Kv1.3 alpha subunit , voltage-gated Kv1.3 potassium channel

GENE ID SPECIES
100328945 Oryctolagus cuniculus
373847 Xenopus laevis
3738 Homo sapiens
16491 Mus musculus
29731 Rattus norvegicus
404303 Gallus gallus
525507 Bos taurus
Selected quality suppliers for anti-KCNA3 (KCNA3) Antibodies
Did you look for something else?