anti-Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 (KCND3) Antibodies

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 Proteins (6) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCND3 56543 Q9Z0V1
KCND3 3752 Q9UK17
KCND3 65195 Q62897
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Top anti-Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 Antibodies at antibodies-online.com

Showing 10 out of 70 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Mammalian Mouse Un-conjugated ISt, IHC, WB   5 mL 2 to 6 Days
$394.53
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KCND3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  HepG2 cell lysate 100 μL 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated WB Anti- Kv4.3 antibody, Western blotting All lanes: Anti Kv4.3  at 0.5ug/ml WB: Mouse Brain Tissue Lysate at 50ug Predicted bind size: 73KD Observed bind size: 73KD 100 μg 4 to 6 Days
$240.00
Details
Guinea Pig Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$507.83
Details
Cow Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  KCND3  Sample Type:  Stomach Tumor lysates  Antibody Dilution:  1.0ug/ml Host:  Mouse  Target Name:  KCND3  Sample Tissue:  Mouse Heart  Antibody Dilution:  1ug/ml 100 μL 2 to 3 Days
$289.00
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  KCND3  Sample Tissue:  Liver Tumor lysates  Antibody Dilution:  1ug/ml Host:  Mouse  Target Name:  KCND3  Sample Tissue:  Mouse Spleen  Antibody Dilution:  1ug/ml 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis in CEM cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB KCND3 antibody used at 1.25 ug/ml to detect target protein. 100 μg 9 to 11 Days
$369.29
Details
Rat Mouse Un-conjugated IHC (p), IP, WB Immunohistochemistry analysis on a paraffin embedded mouse brain section using Kcnd3 monoclonal antibody, clone S75-41 . 100 μg 11 to 12 Days
$460.00
Details

Top referenced anti-Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 Antibodies

  1. Mammalian Monoclonal KCND3 Primary Antibody for ISt, IHC - ABIN1304772 : Duarri, Lin, Fokkens, Meijer, Smeets, Nibbeling, Boddeke, Sinke, Kampinga, Papazian, Verbeek: Spinocerebellar ataxia type 19/22 mutations alter heterocomplex Kv4.3 channel function and gating in a dominant manner. in Cellular and molecular life sciences : CMLS 2015 (PubMed)
    Show all 46 Pubmed References

More Antibodies against Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 Interaction Partners

Mouse (Murine) Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 (KCND3) interaction partners

  1. In ERaKO but not ERaKO mice, the mRNA of Kv4.3 was selectively increased... E2 negatively regulates the density of Ito through ERa, this highlights a potential role for this female hormone in modulating cardiac electrical activity.

  2. Data show that potassium channel Kv4.3 outward current is presented incardiomyocyte lacking the potassium channel Kv4.2 gene (Kv4.2-/-).

  3. The gain-of-function SCNA overexpressing dopamine substantia nigra neurons was in part mediated by an increase of their intrinsic pacemaker frequency caused by a redox-dependent impairment of Kv4.3

  4. The protein levels of KV4.3 and KV2.2 were up-regulated in the hypertrophic smooth muscle cell membrane.

  5. The experiments here demonstrate that Kv4.2, Kv4.3 and Kv1.4 all contribute to the generation of potassium channels in mature cortical pyramidal (CP) neurons; these channels play distinct roles in regulating the intrinsic properties of mature CP neurons.

  6. Taken together, these data suggest that nerve injury causes an epigenetic silencing of K(v)4.3 gene mediated through transcriptional suppressor NRSF in the DRG.

  7. Kv4.3 channel alpha-subunit is found to be one of the components (along with Kv4.2 and Kv1.4) that propagates the voltage-gated potassium current in pyramidal cortical neurons.

  8. Ativation of AT1 receptors by Angioteinsin II or stretch specifically destabilizes cardiac myocyte Kv4.3 channel mRNA by activating NADPH oxidase.

  9. The results show that Kv4.3 is concentrated in layer 1, the bottom of layer 2/3, and in layers 4 and 5/6.

  10. The results presented here suggest that, in contrast with Kv4.2, Kv4.3 is not required for the generation of functional mouse ventricular I(to,f) channels.

  11. Principal neurons of mouse medial nucleus of the trapezoid body possess a small, rapidly inactivating transient outward current (or A-current) that is mediated by Kv4.3 subunits.

  12. NO and NO donors inhibited I(Kv4.3) in a concentration- and voltage-dependent manner.

  13. N-terminal binding of Kv4.3 to the core of KChIP4a mobilizes the KChIP4a N terminus, which serves as the slow inactivation gate.

  14. Downregulation of Kv4.3 and Kv1.5 transcripts by estrogen are one mechanism defining gender-related differences in mouse ventricular repolarization.

Human Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 (KCND3) interaction partners

  1. The alpha subunit of Ito Kv4.3 can interact with and modify the localization of the alpha subunit of IKr hERG, thus providing potentially novel insights into the molecular mechanism of the malignant ventricular arrhythmia in heart failure.

  2. This study Identified a new KCND3 phenotype and novel genes causing Dravet syndrome.

  3. mutations cause a gainoffunction of KV4.3/KChIP2encoded channels by increasing membrane protein expression and slowing channel inactivation.

  4. Mefloquine is a concentration-dependent Ito and hKv4.3 channel blocker.

  5. Altered Kv4.3 channel localization and/or functioning resulting from SCA19/22 mutations may lead to Purkinje cell loss, neurodegeneration and ataxia.

  6. the interaction of DPP10a, expressed in human atrium, with Kv4.3 channels generates a sustained current component of Ito, which may affect late repolarization phase of atrial action potentials.

  7. Kv4.3 K(+) channel is involved in heart hypertrophy/heart failure independently of its electric function.[review]

  8. Demonstrate SEMA3A as a naturally occurring protein that selectively inhibits Kv4.3 and SEMA3A as a possible Brugada syndrome susceptibility gene through a Kv4.3 gain-of-function mechanism.

  9. maps to chromosome 1p21-q21 and identification in Dutch autosomal dominant cerebellar ataxia family

  10. These results indicate that Kv4.3 is likely the target of discrepin and highlight the importance of the basic residue K13, located in the alpha-helix of the toxin, for current blockage.

  11. findings indicate mutations in KCND3 are not a common cause of disease among rarer types of European cerebellar ataxia; however 2 variants were identified in the SCA cases: p.L450F and p.P614S; mutations in KCND3 can cause 2 allelic disorders, SCA19/22 and Brugada syndrome which may co-occur

  12. Report a KV4.3 gain-of-function mutation in early-onset persistent lone atrial fibrillation.

  13. expression of the sodium (SCN5A) and potassium (KCND3) channels as well as the fibrosis content in the ventricles of heart failure and of non-diseased hearts under different post-mortem intervals

  14. The biophysical characteristics of Kv4.3 channels are strongly dependent on temperature.

  15. This study demonistrated that Mutations in KCND3 cause spinocerebellar ataxia type 22 in chinese and japanese.

  16. This study demonistrated that KCND3 mutations cause SCA19 by impaired protein maturation and/or reduced channel function

  17. KCND3 may serve as a rare genetic substrate in the pathogenesis of autopsy-negative sudden unexplained death (SUD) but not sudden infant death syndrome (SIDS) cases.

  18. Human atrial I(to) and cloned hKv4.3 channels are modulated by EGFR kinase via phosphorylation of the Y136 residue and by Src-family kinases via phosphorylation of the Y108 residue.

  19. Deep insights into the mechanism of the regulation of Kv4.3 K channels and the role of Kv4.3 K channels in cell death.

  20. Kv4.3 macromolecular complex and regulators of KCND3 expression is needed to elucidate the role of the Ito current in the pathogenesis of BrS and other J-wave syndromes.

Xenopus laevis Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 (KCND3) interaction partners

  1. biophysical 11-state Markov model of Kv4.3 gating incorporating a direct transition from the open-inactivated state to the closed-inactivated state

  2. Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C in Kv4.3

Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 (KCND3) Antigen Profile

Protein Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene.

Gene names and symbols associated with KCND3

  • potassium voltage-gated channel subfamily D member 3 (KCND3) antibody
  • potassium voltage-gated channel subfamily D member 3 (kcnd3) antibody
  • potassium voltage-gated channel, Shal-related subfamily, member 3 (kcnd3) antibody
  • potassium channel, voltage gated Shal related subfamily D, member 3 (kcnd3) antibody
  • potassium voltage-gated channel, Shal-related family, member 3 (Kcnd3) antibody
  • potassium voltage-gated channel subfamily D member 3 (Kcnd3) antibody
  • potassium channel, voltage gated Shal related subfamily D, member 3 L homeolog (kcnd3.L) antibody
  • AW045978 antibody
  • K(v)4.3 antibody
  • KCND3 antibody
  • kcnd3-A antibody
  • KCND3L antibody
  • KCND3S antibody
  • Kncd3 antibody
  • KSHIVB antibody
  • KV4.3 antibody
  • wu:fi06g01 antibody
  • xKv4.3 antibody
  • zgc:55306 antibody

Protein level used designations for KCND3

potassium voltage-gated channel, Shal-related subfamily, member 3 , potassium voltage-gated channel subfamily D member 3-like , potassium voltage-gated channel subfamily D member 3 , potassium voltage-gated channel, Shal-related family, member 3 , zShal3 , potassium channel Kv4.3 , potassium voltage-gated channel Shal-related subfamily member 3 , potassium channel Kv4.3L , potassium channel Kv4.3M , voltage-gated potassium channel subunit Kv4.3 , potassium ionic channel Kv4.3 , sha1-related potassium channel Kv4.3 , voltage-gated K+ channel , potassium voltage gated channel, Shal-related family, member 3

GENE ID SPECIES
744303 Pan troglodytes
100030530 Monodelphis domestica
100058973 Equus caballus
100076092 Ornithorhynchus anatinus
100394264 Callithrix jacchus
100431693 Pongo abelii
100481914 Ailuropoda melanoleuca
100556636 Anolis carolinensis
100606231 Nomascus leucogenys
327415 Danio rerio
403758 Canis lupus familiaris
539739 Bos taurus
641437 Macaca mulatta
100125015 Xenopus (Silurana) tropicalis
56543 Mus musculus
3752 Homo sapiens
100037946 Sus scrofa
100009472 Oryctolagus cuniculus
65195 Rattus norvegicus
101115919 Ovis aries
378574 Xenopus laevis
374228 Gallus gallus
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