anti-Presenilin Associated, Rhomboid-Like (PARL) Antibodies

PARL encodes a mitochondrial integral membrane protein. Additionally we are shipping PARL Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PARL 55486 Q9H300
PARL 381038 Q5XJY4
PARL 287979 Q3B8P0
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Top anti-PARL Antibodies at antibodies-online.com

Showing 10 out of 49 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Human kidney 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB Figure 1: Western blot analysis using PARL mouse mAb against truncated Trx-PARL recombinant protein (1) and truncated MBP-PARL(aa112-167) recombinant protein (2). Dilution: 1/500 - 1/2000 Figure 2: Immunohistochemical analysis of paraffin-embedded human cerebra (left) and lung carcinoma (right) tissues, showing nuclear localization with DAB staining using MDM4 mouse mAb. Dilution: 1:200~~1000 100 μL Log in to see 10 to 11 Days
$456.07
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: PARL Antibody [NBP1-59496] - Jurkat cell lysate, concentration 0.5ug/ml. Western Blot: PARL Antibody [NBP1-59496] - Sample Tissue: Human Jurkat Antibody Dilution: 1.0 ug/ml 100 μL Log in to see 8 to 11 Days
$488.73
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), WB Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE) Western blot analysis of PARL in 3T3 cell lysate with PARL antibody at (A) 1 and (B) 2 µg/ml. 50 μg Log in to see 6 to 8 Days
$495.00
Details
Human Rabbit Un-conjugated EIA, IF, WB   0.1 mg Log in to see 11 Days
$522.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of extract of HepG2 and MCF7 cells, using PARL antibody. 100 μL Log in to see 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-PARL antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: PARL Antibody [NBP1-80878] - Staining of human cell line A-431 shows positivity in mitochondria. Immunohistochemistry-Paraffin: PARL Antibody [NBP1-80878] - Staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Mouse Un-conjugated ELISA, WB Western Blot: PARL Antibody (8C4B2) [NBP1-51546] - Western blot analysis using PARL mouse mAb against truncated Trx-PARL recombinant protein (1) and truncated MBP-PARL(aa112-167) recombinant protein (2). 0.1 mL Log in to see 7 to 9 Days
$418.10
Details

Top referenced anti-PARL Antibodies

  1. Human Polyclonal PARL Primary Antibody for WB - ABIN541379 : Pellegrini, Passer, Canelles, Lefterov, Ganjei, Fowlkes, Koonin, DAdamio: PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2. in Journal of Alzheimer's disease : JAD 2002 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal PARL Primary Antibody for ELISA, WB - ABIN969340 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 3 Pubmed References

  3. Chicken Polyclonal PARL Primary Antibody for ELISA, ICC - ABIN4343719 : Jeyaraju, Xu, Letellier, Bandaru, Zunino, Berg, McBride, Pellegrini: Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal PARL Primary Antibody for ELISA, WB - ABIN966805 : McQuibban, Saurya, Freeman: Mitochondrial membrane remodelling regulated by a conserved rhomboid protease. in Nature 2003 (PubMed)
    Show all 3 Pubmed References

  5. Cow (Bovine) Polyclonal PARL Primary Antibody for IHC, WB - ABIN2782038 : Walder, Kerr-Bayles, Civitarese, Jowett, Curran, Elliott, Trevaskis, Bishara, Zimmet, Mandarino, Ravussin, Blangero, Kissebah, Collier: The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes. in Diabetologia 2005 (PubMed)
    Show all 2 Pubmed References

More Antibodies against PARL Interaction Partners

Human Presenilin Associated, Rhomboid-Like (PARL) interaction partners

  1. PARL preserves mitochondrial membrane homeostasis via STARD7 processing and is emerging as a critical regulator of protein localization between mitochondria and the cytosol

  2. Study confirmed that common variants in PARL and PINK1 were associated with leprosy. Furthermore, PARL and PINK1 could physically interact with each other and were involved in the highly connected network formed by reported leprosy susceptibility genes.

  3. PDK2/PARL senses defects in mitochondrial bioenergetics.

  4. Adipogenic process can be dissected into 3 stages according to the participation of PARL-PINK1-Parkin system. Findings reveal the sequential adipogenic events directed by PARL-PINK1-Parkin system, add more evidence supporting the convergence of pathogenesis leading to neurodegenerative and metabolic disease

  5. These findings enrich the allelic spectrum of ABCC5 in PACG. We identified no tagging SNP responsible for the association of the whole region.

  6. These results reveal a pro-apoptotic function of PARL and identify PARL-mediated Smac processing and cytochrome c release facilitated by OPA1-dependent cristae remodelling as two independent pro-apoptotic pathways in mitochondria.

  7. Its mutations are a rare cause of PD and genetic variants are neither strong nor common risk factors in Parkinson disease.

  8. pathogenic PINK1 mutants which are not cleaved by PARL affect PINK1 kinase activity and the ability to induce PARK2-mediated mitophagy.

  9. Common genetic variants of the PINK1 and PARL genes are unlikely to be involved in schizophrenia.

  10. the frequency of the haplotype AAC, and AAT were significantly higher in the unaffected cases and the frequencies of haplotype GGT were significantly higher in LHON cases

  11. Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.

  12. p.S77N variant, and, possibly, mutations in the PARL protein overall, are not a frequent cause of autosomal recessive early-onset Parkinson's disease

  13. work provides unexpected insights into the structural determinants regulating Parl stability and activity in vivo, and reveals a complex cascade of proteolytic events controlling the function of the protease in the mitochondrion

  14. PARL deficiency impairs PARKIN recruitment to mitochondria.

  15. the PARL-catalyzed removal of the Pink1 signal sequence in the canonical import pathway acts as a cellular checkpoint for mitochondrial integrity

  16. Mitochondrial protease PARL cleaves PINK1 at position A103.

  17. Data show that no association between PARL gene SNPs and LHON in Chinese patients with m.11778G>A.

  18. variants of PARL are suggested to influence cell death by apoptosis which has long been believed to intrigue the neurodegeneration of LHON.

  19. Results suggest that genetic variation within PARL influences mitochondrial abundance and integrity.

  20. results indicate a different function and mechanism of Hax1 in apoptosis and re-opens the question of whether mammalian PARL, in addition to apoptosis, regulates mitochondrial stress response through Omi/HtrA2 processing.

Mouse (Murine) Presenilin Associated, Rhomboid-Like (PARL) interaction partners

  1. Downregulation of PARL after ischemia is a key step in ischemic neuronal injury, and that it decreases HtrA2 processing and increases neuronal vulnerability.

  2. the OPA1/PARL dependent pathway of cristae remodeling is implicated in heat shock.

  3. Suppression of PARL protein in healthy myotubes lowered mitochondrial mass and insulin-stimulated glycogen synthesis and increased reactive oxygen species production.

  4. results indicate a different function and mechanism of Hax1 in apoptosis and re-opens the question of whether mammalian PARL, in addition to apoptosis, regulates mitochondrial stress response through Omi/HtrA2 processing.

  5. Parl-/- mitochondria display reduced levels of OPA1, and OPA1 specifically targeted to IMS complements Parl-/- cells, substantiating the importance of PARL in OPA1 processing.(PARL protein, mouse)

  6. Hax1, is required to suppress apoptosis in lymphocytes and neurons; suppression requires the interaction of Hax1 with the mitochondrial proteases Parl and HtrA2

Zebrafish Presenilin Associated, Rhomboid-Like (PARL) interaction partners

  1. This study demonistrated that Zebrafish Parla- and Parlb-deficiency affects dopaminergic neuron patterning and embryonic survival.

PARL Antigen Profile

Protein Summary

This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with PARL

  • presenilin associated rhomboid like (PARL) antibody
  • presenilin associated, rhomboid-like (Parl) antibody
  • presenilin associated rhomboid like (Parl) antibody
  • presenilin associated, rhomboid-like a (parla) antibody
  • D16Ertd607e antibody
  • parl antibody
  • PRO2207 antibody
  • Psarl antibody
  • PSARL1 antibody
  • PSENIP2 antibody
  • RHBDS1 antibody
  • zgc:112986 antibody

Protein level used designations for PARL

mitochondrial intramembrane cleaving protease PARL , mitochondrial intramembrane-cleaving protease PARL , presenilins-associated rhomboid-like protein, mitochondrial , rhomboid 7 homolog 1 , presenilin associated, rhomboid-like isoform 1 preproprotein , presenilin associated, rhomboid-like preproprotein , parlb

GENE ID SPECIES
55486 Homo sapiens
381038 Mus musculus
287979 Rattus norvegicus
424767 Gallus gallus
488100 Canis lupus familiaris
100058851 Equus caballus
514191 Bos taurus
100722572 Cavia porcellus
100351338 Oryctolagus cuniculus
541485 Danio rerio
Selected quality suppliers for anti-PARL (PARL) Antibodies
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