anti-Programmed Cell Death 10 (PDCD10) Antibodies

PDCD10 encodes an evolutionarily conserved protein associated with cell apoptosis. Additionally we are shipping PDCD10 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PDCD10 11235 Q9BUL8
PDCD10 56426 Q8VE70
PDCD10 494345 Q6NX65
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Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB PDCD10 Antibody (Center)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PDCD10 antibody detected the PDCD10 protein (arrow). 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 16 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti PDCD10 Polyclonal Antibody (ABIN872581), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
Human Rabbit Un-conjugated IF, WB Immunofluorescence staining (green) of Human foreskin (cryo-section of unfixed tissue) with anti-Human CCM3 antibody Cat.-No. AP26023PU (K5548, dilution1/50). A) Note specific staining in the epidermis and in the wall of microvessels. B) Negative control of a consecutive section. Nuclei counter-stained with Dapi (blue). <em>Specimen provided by Prof. Dr. J. Wilting, Goettingen.The experiment was performed by the research group of Prof. Dr. J. Wilting, University Göttingen, Germany.</em> Western Blot using Anti Human CCCM3 antibody Cat.-No. AP26023PU. The experiment was performed by Elisabetta  Dejana's group. IF OM.IEO-Campus, Milan Italy. 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
Human Rabbit HRP IHC (p), WB   100 μL Log in to see 14 to 21 Days
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
Human Rabbit Cy5 IF (p)   100 μL Log in to see 14 to 21 Days

PDCD10 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine) ,

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Rat (Rattus) ,

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More Antibodies against PDCD10 Interaction Partners

Human Programmed Cell Death 10 (PDCD10) interaction partners

  1. CCM3 restrains ANGPT2 (show UNC13B Antibodies)release from endothelial cells and maintains endot (show VAMP3 Antibodies)helial junctions. CCM3 depletion leads to increa (show ANGPT2 Antibodies)sed ANGPT2 release.

  2. Data indicated that rs9853967 and rs11714980 polymorphisms in CCM3 and SERPINI1respectively could be associated with a protective role in cerebral cavernous malformations disease.

  3. Inhibition of Notch (show NOTCH1 Antibodies) and activation of VEGF (show VEGFA Antibodies)/p38 (show CRK Antibodies) signaling were involved in miR (show MLXIP Antibodies)-425-5p/CCM3 mediated inhibition of angiogenesis by sodium arsenite.

  4. Loss of endothelial programmed cell death 10 activates glioblastoma cells and promotes tumor growth.

  5. Studies suggest that the 3 proteins of the Cerebral Cavernous Malformations (CCM) complex KRIT1/CCM1 (show KRIT1 Antibodies), CCM2/malcavernin (show CCM2 Antibodies) and CCM3/PDCD10 not only require one another for reciprocal stabilization, but also act as a platform for signal transduction.

  6. Study highlights the potential role of CCM3 in regulating tight junction complex organization and brain endothelial barrier permeability through CCM3-ERK1/2 (show MAPK1/3 Antibodies)-cortactin (show CTTN Antibodies) cross-talk

  7. A novel CCM3 missense mutation (c.422T>G) detected in 2 Greek brothers with cerebral cavernous malformations causes a loss of function in Pdcd10 protein due to its localization in the 8th helix. It affects Leu141. It may play a role in angiogenesis.

  8. The proto-oncogene (show RAB1A Antibodies) PDCD10 is direct target of miR (show MLXIP Antibodies)-103 that can suppress Prostate cancer proliferation and migration by down-regulating the PDCD10.

  9. We report for the first time that PDCD10 expression is downregulated in GBM, which is associated with the activation of Akt (show AKT1 Antibodies) signaling protein

  10. miR (show MLXIP Antibodies)-181b was upregulated by hypoxia in retinoblastoma in an HIF-1a (show HIF1A Antibodies)-independent manner. Additionally, miR (show MLXIP Antibodies)-181b exerts its angiogenic function, at least in part, by inhibiting PDCD10 and GATA6 (show GATA6 Antibodies).

Mouse (Murine) Programmed Cell Death 10 (PDCD10) interaction partners

  1. CCM3 suppresses UNC13B (show UNC13B Antibodies)- and vesicle-associated membrane protein 3 (VAMP3 (show VAMP3 Antibodies))-dependent exocytosis of angiopoietin 2 (ANGPT2 (show ANGPT2 Antibodies)) in brain endothelial cells. CCM3 deficiency in endothelial cells augments the exocytosis and secretion of ANGPT2 (show ANGPT2 Antibodies), which is associated with destabilized endothelial cell junctions, enlarged lumen formation and endothelial cell-pericyte dissociation.

  2. CCM3 expression and it's role during ovary and testis development

  3. Study shows that PDCD10 mutations result in vascular permeability mediated by ROCK activity and a particularly severe clinical phenotype of patients and mouse model for cerebral cavernous malformation disease.

  4. Data show that sulindac sulfide (show SQRDL Antibodies) and sulindac sulfone, which attenuate beta-catenin (show CTNNB1 Antibodies) transcription activity, reduce vascular malformations in endothelial programmed cell death 10 protein CCM3-deficient mice.

  5. CCM3 has both cell autonomous and cell non-autonomous functions in neural progenitors and is specifically required in radial glia and newly born pyramidal neurons migrating through the subventricular zone

  6. Although CCM3 stabilizes STK24, it counteracts STK24-mediated inhibition of exocytosis by recruiting STK24 away from the C2B domain through its Ca(2+)-sensitive interaction with UNC13D C2A domain.

  7. Pdcd10 has a different role in cerebral cavernous malformation than Ccm2 (show CCM2 Antibodies) and Krit1 (show KRIT1 Antibodies)

  8. Ccm3 has both neural cell autonomous and nonautonomous functions.

  9. Stabilization of VEGFR2 (show KDR Antibodies) signaling by cerebral cavernous malformation 3 (also known as PDCD10) is critical for vascular development.

PDCD10 Antigen Profile

Protein Summary

This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with PDCD10

  • programmed cell death 10 (PDCD10) antibody
  • programmed cell death 10 (Pdcd10) antibody
  • programmed cell death 10 S homeolog (pdcd10.S) antibody
  • 2410003B13Rik antibody
  • Ccm3 antibody
  • Tfa15 antibody
  • Tfar15 antibody

Protein level used designations for PDCD10

programmed cell death 10 , TF-1 cell apoptosis-related protein 15 , apoptosis-related protein 15 , cerebral cavernous malformations 3 protein , programmed cell death protein 10

100232628 Taeniopygia guttata
11235 Homo sapiens
56426 Mus musculus
494345 Rattus norvegicus
425003 Gallus gallus
100157978 Sus scrofa
379916 Xenopus laevis
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