Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) ELISA Kits

PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. Additionally we are shipping PCSK9 Antibodies (168) and PCSK9 Proteins (61) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PCSK9 255738 Q8NBP7
PCSK9 100102 Q80W65
PCSK9 298296 P59996
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Top PCSK9 ELISA Kits at antibodies-online.com

Showing 10 out of 89 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.11 ng/mL 0.45-30 ng/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$788.33
Details
Rat 46.88 pg/mL 93.75-6000 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details
Monkey 1.1 pg/mL 1.1-800 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$1,026.67
Details
Mouse 6.0 pg/mL 15.6 pg/mL - 1000 pg/mL 96 Tests Log in to see 13 to 16 Days
$757.89
Details
Rabbit 0.188 ng/mL 0.31 ng/mL - 20 ng/mL A typical standard curve 96 Tests Log in to see 13 to 16 Days
$576.62
Details
Pig 0.469 ng/mL 0.781-50 ng/mL Typical standard curve 96 Tests Log in to see 12 to 14 Days
$715.00
Details
Guinea Pig 0.094 ng/mL 0.15 ng/mL - 10 ng/mL A typical standard curve 96 Tests Log in to see 13 to 16 Days
$576.62
Details
Chicken 4.688 ng/mL 7.813-500 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Sheep
  96 Tests Log in to see 15 to 18 Days
$707.14
Details
Dog
  96 Tests Log in to see 15 to 18 Days
$707.14
Details

Top referenced PCSK9 ELISA Kits

  1. Human PCSK9 ELISA Kit for Sandwich ELISA - ABIN2345049 : Jin, Park, Kim, Vaziri: Plasma PCSK9 in nephrotic syndrome and in peritoneal dialysis: a cross-sectional study. in American journal of kidney diseases : the official journal of the National Kidney Foundation 2014 (PubMed)
    Show all 3 Pubmed References

  2. Human PCSK9 ELISA Kit for Sandwich ELISA - ABIN820112 : Dogan, Akman, Simsek, Ozdem, Comak, Gokceoglu, Kardelen, Koyun: Assessment of left ventricular function by tissue Doppler echocardiography in pediatric chronic kidney disease. in Renal failure 2015 (PubMed)
    Show all 3 Pubmed References

  3. Rat (Rattus) PCSK9 ELISA Kit for Competition ELISA - ABIN820114 : Sucajtys-Szulc, Szolkiewicz, Swierczynski, Rutkowski: Up-regulation of liver Pcsk9 gene expression as a possible cause of hypercholesterolemia in experimental chronic renal failure. in Molecular and cellular biochemistry 2016 (PubMed)
    Show all 3 Pubmed References

  4. Mouse (Murine) PCSK9 ELISA Kit for Sandwich ELISA - ABIN2685159 : Seidah, Benjannet, Wickham, Marcinkiewicz, Jasmin, Stifani, Basak, Prat, Chretien: The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
    Show all 3 Pubmed References

  5. Rabbit PCSK9 ELISA Kit for Sandwich ELISA - ABIN5521366 : Elseweidy, Amin, Atteia, El-Zeiky, Al-Gabri et al.: New Insight on a Combination of Policosanol and 10-Dehydrogingerdione Phytochemicals as Inhibitors for Platelet Activation Biomarkers and Atherogenicity Risk in Dyslipidemic Rabbits: Role of CETP and ... in Applied biochemistry and biotechnology 2019 (PubMed)
    Show all 2 Pubmed References

  6. Rat (Rattus) PCSK9 ELISA Kit for Sandwich ELISA - ABIN434248 : Shafik, Baalash, Ebeid: Synergistic Cardioprotective Effects of Combined Chromium Picolinate and Atorvastatin Treatment in Triton X-100-Induced Hyperlipidemia in Rats: Impact on Some Biochemical Markers. in Biological trace element research 2017 (PubMed)

More ELISA Kits for PCSK9 Interaction Partners

Human Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. PCSK9 loss-of-function variants were not associated with neurocognitive impairment among a general population sample of middle-age and older African Americans.

  2. Here, the authors found that PCSK9 expression was increased in periodontitis patients and Porphyromonas gingivalis (Pg)-infected mice. Loss of PCSK9 attenuated Pg-induced periodontal bone loss in mice.

  3. Results indicate a positive correlation between plasma PCSK9 and sdLDL in a community-dwelling cohort, but not in type 2 diabetic subpopulation, after confounder adjustment.

  4. The presence of multiple PCSK9 LOF alleles decreased the risk of 1-year death or IRR in sepsis survivors. Biological measures suggest this may be related to an enhanced resolution of the initial infection.

  5. High PCSK9 expression is associated with atherosclerosis and liver cancer.

  6. PCSK9 proteolysis acts as a commonly perturbed but critical switch in controlling lipid homeostasis.

  7. Data indicate the association of proprotein convertase subtilisin kexin type 9 (PCSK9) A/G (rs505151) single nucleotide polymorphisms (SNPs) with coronary artery disease (CAD) risk in the north Indian population.

  8. Mutation spectrum and genotype-phenotype correlation was analyzed in patients with familial hypercholesterolemia in Chinese population.

  9. Given that overexpression of these LOF PCSK9 variants does not cause UPR activation under normal homeostatic conditions, therapeutic strategies aimed at blocking the autocatalytic cleavage of PCSK9 in the ER represent a viable strategy for reducing circulating PCSK9

  10. PCSK9 was inconsistently associated with cardiovascular (CV) events in populations with type 2 diabetes. The association may depend on the level of CV risk and the background treatment.

  11. These findings support a model in which SURF4 functions as an endoplasmic reticulum cargo receptor mediating the efficient cellular secretion of PCSK9.

  12. A long-term physical activity caused increase in PCSK9 blood levels.

  13. The present study shows that serum PCSK9 levels, but not PCSK9 polymorphisms, are associated with coronary artery disease risk in Southern Chinese Han population, and that serum PCSK9 levels are positively associated with AIP

  14. In Japanese male subjects, the concentrations of serum PCSK9 and TBIL were correlated with periodontal parameters.

  15. C679X loss-of-function PCSK9 variant lowers fasting glucose levels.

  16. There was no protective or no deleterious effect of carrying PCSK9 LOF mutations on AD [Alzheimer disease]prevalence nor on age of onset, even when stratified by apolipoprotein E epsilon 4 genotype or by gender. Conclusion: Our data indicate that carrying PCSK9 LOF mutations has a neutral effect on neurocognitive health and the prevalence of AD [Alzheimer disease].

  17. High serum PCSK9 levels predict acute coronary syndrome occurrence at 24-month follow-up after carotid endarterectomy in patients with severe carotid artery stenosis.

  18. Taken together, the present study provides evidence of a pro-inflammatory action of PCSK9 on macrophages, mainly dependent by the LDLR.

  19. HepG2 cell lines transfected with siRNA directed to PCSK9 were challenged with Hcy, homocysteine thiolactone (HTL), testosterone, 5alpha-dihydroxytestosterone (5alpha-DHT), or estradiol for 24h, leading to an overt expression of PCSK9 and down-regulated expression of LDLR.

  20. Plasma PCSK9 levels and lipoprotein distribution are preserved in hypolipoproteinemia carriers.

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. High PCSK9 expression is associated with atherosclerosis and liver cancer.

  2. Given that overexpression of these LOF PCSK9 variants does not cause UPR activation under normal homeostatic conditions, therapeutic strategies aimed at blocking the autocatalytic cleavage of PCSK9 in the ER represent a viable strategy for reducing circulating PCSK9

  3. Data suggest that expression of Pcsk9 and Ldlr in liver and pancreas can be regulated by dietary measures; here, dietary supplementation with quercetin-3-glucoside modulates expression of Pcsk9 and Ldlr in prevention of hyperlipidemia and hyperinsulinemia induced by high dietary cholesterol. (Pcsk9 = proprotein convertase subtilisin/kexin type-9; Ldlr = low-density lipoprotein receptor)

  4. The data of the present study demonstrated that the PCSK9 shRNAmediated antiapoptotic effect induced by MCAO in hyperlipidemic mice is associated with ApoER2 downregulation, which may be a potential new therapy for stroke treatment in patients with hyperlipidemia.

  5. It was concluded that quercetin inhibits oxLDLinduced lipid droplets in RAW264.7 cells by upregulation of ABCAl, ABCG1, LXRalpha and downregulation of PCSK9, p53, p21 and p16.

  6. PCSK9 overexpression in the aorta may promote acute aortic dissection.

  7. Genetically determined PCSK9 deficiency might be associated with ectopic fat accumulation.

  8. The present study aimed to explore the direct toxicity of proprotein convertase subtilisin/kexin type 9 (PCSK9) to atherosclerosis (AS) and its association with apoptotic endothelial cells.

  9. present anti-PCSK9 vaccine induced long-lasting anti-PCSK9 antibody production and improved lipoprotein profiles. Thus, anti-PCSK9 vaccine could become a new option for the treatment of dyslipidemia as a long-acting therapy in future

  10. PCSK9 may act as an inflammatory mediator in the pathogenesis of atherosclerosis via TLR4/NF-kappaB signaling pathway.

  11. PCSK9, by sustaining smooth muscle cell synthetic phenotype, proliferation, and migration, may play a pro-atherogenic role in the arterial wall

  12. PCSK9 inhibits lipoprotein(a) clearance through the LDLR.

  13. Use Crispr-Cas system to introduce nonsense variants into PCSK9 to lower blood cholesterol levels.

  14. Studied the combination model of a single AAV-PCSK9 injection, high-fat diet, and partial carotid ligation which induces robust atherosclerosis in the flow-disturbed carotid artery within 3 weeks in C57 mice, and results suggest this is a quick and convenient model to study atherosclerosis and mechanisms using any knockout or transgenic mice without having to generate double knockouts.

  15. These observations suggest positive feedback interplay between SMC-derived PCSK9 and mtDNA damage in the proinflammatory milieu involving mtROS. This interaction results in cellular injury, characterized by apoptosis-a hallmark of atherosclerosis.

  16. AdipoR activation by agonists regulated PCSK9 expression and inhibits atherosclerosis in apoE(-/-) mice.

  17. Adeno-associated virus mediated infection with a mouse PCSK9 gain-of-function mutation is a rapid, easy, and efficient approach for inducing hypercholesterolemia and promoting abdominal aortic aneurysms in C57BL/6 mice infused with angiotensin II.

  18. conditions that cause ER stress regardless of their ability to dysregulate ER Ca(2+) inhibit PCSK9 secretion, thereby reducing PCSK9-mediated LDLR degradation and promoting LDLR-dependent hepatic cholesterol uptake.

  19. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation.

  20. PCSK9 increases hepatic lipid and lipoprotein production via apoE- and LDLR-dependent mechanisms

Pig (Porcine) Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. the PCSK9-gain-of-function mutation induces rapid development of atherosclerosis in peripheral vessels of Ossabaw pigs, which is exacerbated by a high-cholesterol diet.

PCSK9 Antigen Profile

Antigen Summary

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Gene names and symbols associated with PCSK9

  • proprotein convertase subtilisin/kexin type 9 L homeolog (pcsk9.L) antibody
  • proprotein convertase subtilisin/kexin type 9 (pcsk9) antibody
  • proprotein convertase subtilisin/kexin type 9 (PCSK9) antibody
  • proprotein convertase subtilisin/kexin type 9 (Pcsk9) antibody
  • AI415265 antibody
  • AI747682 antibody
  • FH3 antibody
  • HCHOLA3 antibody
  • LDLCQ1 antibody
  • NARC-1 antibody
  • Narc1 antibody
  • PC9 antibody

Protein level used designations for PCSK9

proprotein convertase subtilisin/kexin type 9 , convertase subtilisin/kexin type 9 preproprotein , neural apoptosis regulated convertase 1 , subtilisin/kexin-like protease PC9 , NARC-1 , convertase subtilisin , neural apoptosis-regulated convertase 1 , proprotein convertase 9 , proprotein convertase PC9 , proprotein convertase subtilisin/kexin type 9 preproprotein , Proprotein convertase 9 , Subtilisin/kexin-like protease PC9

GENE ID SPECIES
495509 Xenopus laevis
100150316 Danio rerio
100544916 Meleagris gallopavo
255738 Homo sapiens
100102 Mus musculus
298296 Rattus norvegicus
424664 Gallus gallus
100731533 Cavia porcellus
717147 Macaca mulatta
100971792 Pan paniscus
456880 Pan troglodytes
100395116 Callithrix jacchus
100620501 Sus scrofa
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