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PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family.
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Mouse (Murine) PCSK9 ELISA Kit for Sandwich ELISA - ABIN2685159
Seidah, Benjannet, Wickham, Marcinkiewicz, Jasmin, Stifani, Basak, Prat, Chretien: The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. in Proceedings of the National Academy of Sciences of the United States of America 2003
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Human PCSK9 ELISA Kit for Sandwich ELISA - ABIN2345049
Jin, Park, Kim, Vaziri: Plasma PCSK9 in nephrotic syndrome and in peritoneal dialysis: a cross-sectional study. in American journal of kidney diseases : the official journal of the National Kidney Foundation 2014
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Human PCSK9 ELISA Kit for Sandwich ELISA - ABIN820112
Dogan, Akman, Simsek, Ozdem, Comak, Gokceoglu, Kardelen, Koyun: Assessment of left ventricular function by tissue Doppler echocardiography in pediatric chronic kidney disease. in Renal failure 2015
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Rat (Rattus) PCSK9 ELISA Kit for Sandwich ELISA - ABIN434248
Shafik, Baalash, Ebeid: Synergistic Cardioprotective Effects of Combined Chromium Picolinate and Atorvastatin Treatment in Triton X-100-Induced Hyperlipidemia in Rats: Impact on Some Biochemical Markers. in Biological trace element research 2017
These results suggest that PCSK9 rs7552841 is associated with plasma lipids profiles only in female adolescents, but not in male students. This association can be modified and negated by posttraumatic stress disorder.
PCSK9 carriers tended to be associated with an increased response to simvastatin therapy
PCSK9 polymorphism may affect HIV pathogenesis, particularly in HIV/hepatitis C coinfected women. A likely mechanism for this effect is PCSK9-mediated regulation of cholesterol metabolism.
There was no relationship between plasma PCSK9 levels and arterial stiffness.
PCSK9 variants associated with lower LDL cholesterol were also associated with circulating higher fasting glucose concentration, body weight and an increased risk of type 2 diabetes.
ABGL4, LRP8 (show LRP8 ELISA Kits) and PCSK9 polymorphisms and gene interactions increase cardiometabolic risk.
these results provide insights into a novel coordinated interplay among three important molecular players in lipid homeostasis - circulating miR (show MLXIP ELISA Kits)-24, miR (show MLXIP ELISA Kits)-223 and PCSK9 - whose regulation is affected by HCV infection and treatment-based viral cure.
The present study aimed to explore the direct toxicity of proprotein convertase subtilisin/kexin type 9 (PCSK9) to atherosclerosis (AS) and its association with apoptotic endothelial cells.
The minor allele frequency of the PCSK9 A443T, I474V, E670G, and C679X polymorphisms in healthy and malaria-infected Malian children was 0.12, 0.20, 0.26, and 0.02, respectively. 17.6% of subjects carried two of the four SNPs examined. Carriers of the minor allele of the E670G PCSK9 polymorphism might be more susceptible to severe malaria.
Circulating PCSK9 concentration as a continuous variable was not significantly associated with the risk of cardiovascular events. More well-designed studies are needed to clarify the role of PCSK9 in cardiovascular risk.
present anti-PCSK9 vaccine induced long-lasting anti-PCSK9 antibody production and improved lipoprotein profiles. Thus, anti-PCSK9 vaccine could become a new option for the treatment of dyslipidemia as a long-acting therapy in future
PCSK9 may act as an inflammatory mediator in the pathogenesis of atherosclerosis via TLR4 (show TLR4 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) signaling pathway.
PCSK9, by sustaining smooth muscle cell synthetic phenotype, proliferation, and migration, may play a pro-atherogenic role in the arterial wall
PCSK9 inhibits lipoprotein(a) clearance through the LDLR (show LDLR ELISA Kits).
Use Crispr-Cas (show CTNND1 ELISA Kits) system to introduce nonsense variants into PCSK9 to lower blood cholesterol levels.
Studied the combination model of a single AAV-PCSK9 injection, high-fat diet, and partial carotid ligation which induces robust atherosclerosis in the flow-disturbed carotid artery within 3 weeks in C57 mice, and results suggest this is a quick and convenient model to study atherosclerosis and mechanisms using any knockout or transgenic mice without having to generate double knockouts.
These observations suggest positive feedback interplay between SMC (show DYM ELISA Kits)-derived PCSK9 and mtDNA damage in the proinflammatory milieu involving mtROS. This interaction results in cellular injury, characterized by apoptosis-a hallmark of atherosclerosis.
AdipoR activation by agonists regulated PCSK9 expression and inhibits atherosclerosis in apoE (show APOE ELISA Kits)(-/-) mice.
Adeno (show ADORA2A ELISA Kits)-associated virus mediated infection with a mouse PCSK9 gain-of-function mutation is a rapid, easy, and efficient approach for inducing hypercholesterolemia and promoting abdominal aortic aneurysms in C57BL/6 mice infused with angiotensin II.
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
proprotein convertase subtilisin/kexin type 9
, convertase subtilisin/kexin type 9 preproprotein
, neural apoptosis regulated convertase 1
, subtilisin/kexin-like protease PC9
, convertase subtilisin
, neural apoptosis-regulated convertase 1
, proprotein convertase 9
, proprotein convertase PC9
, proprotein convertase subtilisin/kexin type 9 preproprotein
, Proprotein convertase 9
, Subtilisin/kexin-like protease PC9