Prostaglandin E Synthase Proteins (PTGES)

The protein encoded by PTGES is a glutathione-dependent prostaglandin E synthase. Additionally we are shipping Prostaglandin E Synthase Antibodies (58) and Prostaglandin E Synthase Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTGES 9536 O14684
PTGES 64292 Q9JM51
Rat PTGES PTGES 59103  
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Top Prostaglandin E Synthase Proteins at

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days

PTGES Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

More Proteins for Prostaglandin E Synthase (PTGES) Interaction Partners

Human Prostaglandin E Synthase (PTGES) interaction partners

  1. this paper focuses on recent studies that have demonstrated the involvement of mPGES-1 in pathological brain diseases--{REVIEW}

  2. Studied iNOS(inducible nitric oxide synthase (show NOS2 Proteins)) activation thru mPGES-1 (microsomal prostaglandin E synthase-1) signaling driven by EGFR (EGF receptor (show EGFR Proteins)) in cancer progression models.

  3. COX-2 and mPGES-1-dependent synthesis of PGE2 contributes to a dedifferentiated aortic smooth muscle cell phenotype.

  4. Several studies provide evidence that the expression of mPGES1 is regulated by a number of transcriptional factors and inducible in conditions of inflammation and hypoxia.[review]

  5. The Genome Wide Area Study, using a phenotyping algorithm for asthma for data mining electronic medical records, identified four asthma susceptibility loci: 6p21.31, 9p21.2, and 10q21.3 in the European American population; and the prostaglandin synthase E gene (PTGES) at 9q34.11 in African Americans. Biologic support exists for genes at the 9p21.2 and 9q34.11 loci TEK (show TEK Proteins), encoding the endothelial tyrosine in animal studies.

  6. C-myc (show MYC Proteins) regulates mPGES1 expression by binding to the proximal promoter. C-myc (show MYC Proteins) transfection in HeLa cells up-regulates mPGES1 mRNA and protein expression.

  7. COX-2 and mPGES-1 have roles in arachidonic acid regulation of inflammatory prostaglandin E2 biosynthesis

  8. The identified amino acid residues can act as target sites for the design and development of drug candidates against mPGES-1

  9. These findings support the value of a prognostic and predictive role for mPGES1.

  10. Data show that statins limit hepatic myofibroblasts proliferation via a cyclooxyegnase-2 (COX-2) and microsomal PGE (show LIPF Proteins) synthase-1 (mPGES-1) dependent pathway.

Mouse (Murine) Prostaglandin E Synthase (PTGES) interaction partners

  1. that mPGES-1 exerts a potentially protective effect against renal fibrosis and inflammation induced by unilateral ureteral obstruction in mice

  2. In line with the acetyltransferase activity of p300 (show NOTCH1 Proteins), H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC (show HDAC3 Proteins) activity maintains PTGES1 expression by recruiting p300 (show NOTCH1 Proteins) to its gene

  3. The findings suggest that COX-2/mPGES-1/PGE2 axis could be activated by albumin (show ALB Proteins) in the proximal tubular cells via a NLRP3 (show NLRP3 Proteins) inflammasome-mediated mechanism and could thus contribute to proteinuria-related renal tubular cell injury.

  4. mPGES-1 overexpression prevents Fas (show FAS Proteins)-induced hepatocyte apoptosis and liver injury through activation of Akt (show AKT1 Proteins) .

  5. The expression of Lcn2 (show LCN2 Proteins) and mPGES-1 is strongly stimulated by lipopolysaccharide (LPS (show TLR4 Proteins)), indicating that Lcn2 (show LCN2 Proteins) mediates LPS (show TLR4 Proteins)-induced inflammation. These findings shed light on the role of Lcn2 (show LCN2 Proteins) during decidualization.

  6. The results show that mPges-1 may be a direct downstream target gene of the P4 receptor (show PGR Proteins).

  7. mPges-1 depletion modestly increased thrombogenesis in LDL-receptor (show LDLR Proteins) knockout mice. This response was markedly further augmented by coincident deletion of the I prostanoid receptor.

  8. Data (including data from studies in knockout mice) suggest interactions of cholinergic/prostaglandin systems participate in neuroimmunomodulation; microsomal Ptges-1 is part of cholinergic anti-inflammatory response in chronic inflammatory diseases.

  9. Prostacyclin synthase (show PTGIS Proteins) and prostaglandin E synthase-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis.

  10. Gas6 (show GAS6 Proteins), through upregulation of Ptges/PGE2, contributes to cancer-induced venous thrombosis.

Cow (Bovine) Prostaglandin E Synthase (PTGES) interaction partners

  1. The objective of this study was to evaluate the mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS 2 (show PTGS2 Proteins)), prostaglandin F2alpha synthase (PTGFS) and prostaglandin E2 microsomal synthase 1 (mPTGES 1) in the endometrium of repeat-breeding cows with and without subclinical endometritis.

  2. Prostaglandin E synthase interacts with inducible heat shock protein 70 (show HSPA1A Proteins) after heat stress in bovine primary dermal fibroblast cells.

  3. Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF (show TNF Proteins)) and Fas (show FAS Proteins) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.

  4. Data suggest that elevated temperatures stimulate PGE2 production in ampullary oviduct by increasing expression of PGES and HSP90AA1 (show HSP90AA1 Proteins) (heat shock 90 kD protein 1 alpha).

  5. PGES pathway is responsible for the endometrial production of PGE (show LIPF Proteins)(2) in the bovine endometrium during the estrous cycle

Horse (Equine) Prostaglandin E Synthase (PTGES) interaction partners

  1. This study showed that COX-1 (show PTGS1 Proteins) and COX-2 (show PTGS2 Proteins) in genital carcinomas in the horse is poor; microsomal PGES-1 is more prominently expressed.

Prostaglandin E Synthase (PTGES) Protein Profile

Protein Summary

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.

Gene names and symbols associated with PTGES

  • prostaglandin E synthase (PTGES)
  • prostaglandin E synthase S homeolog (ptges.S)
  • prostaglandin E synthase (Ptges)
  • 2410099E23Rik protein
  • D2Ertd369e protein
  • MGC80290 protein
  • MGST-IV protein
  • MGST1-L1 protein
  • MGST1L1 protein
  • mPGES protein
  • MPGES-1 protein
  • Pges protein
  • PIG12 protein
  • PP102 protein
  • PP1294 protein
  • PTGES protein
  • TP53I12 protein

Protein level used designations for PTGES

microsomal prostaglandin E synthase-1 , prostaglandin E synthase , MGST1-like 1 , glutathione S-transferase 1-like 1 , microsomal glutathione S-transferase 1-like 1 , microsomal prostaglandin E synthase 1 , p53-induced apoptosis protein 12 , p53-induced gene 12 protein , tumor protein p53 inducible protein 12

417193 Gallus gallus
654407 Sus scrofa
446534 Xenopus laevis
473071 Pan troglodytes
9536 Homo sapiens
64292 Mus musculus
59103 Rattus norvegicus
100733230 Cavia porcellus
282019 Bos taurus
480698 Canis lupus familiaris
100034143 Equus caballus
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