Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. Additionally we are shipping PTGS1 Antibodies (152) and PTGS1 Kits (71) and many more products for this protein.
Showing 9 out of 10 products:
This study showed that COX-1 and COX-2 (show PTGS2 Proteins) in genital carcinomas in the horse is poor; microsomal PGES (show PTGES Proteins)-1 is more prominently expressed.
COX-1 and COX-2 (show PTGS2 Proteins) genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 (show PTGS2 Proteins) gene expression at each subsequent time point, compared with baseline values.
In this study, both COX-1 and COX-2 (show PTGS2 Proteins) were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2 (show PTGS2 Proteins).
Immunoreactivity for COX-1 and COX-2 (show PTGS2 Proteins) is high in equine corneal SCC (show CYP11A1 Proteins), possibly indicating that COX (show CPOX Proteins) plays a role in oncogenesis or progression of this tumor type at this site.
These results suggest that licochalcones inhibit collagen-induced platelet aggregation accompanied by inhibition of COX-1 activity.
Data (including data from studies in knockout mice) suggest that delayed parturition in Cox-1 knockout mice is result of impaired luteolysis and cervical dilation, despite the presence of strong uterine contractions.
Data suggest that Il4 (show IL4 Proteins) (usually released from helper T-cells) induces Cox1 in macrophages at post-transcriptional level; activation of Ampk (show PRKAA1 Proteins) (catalytic subunit Prkaa1 (show PRKAA1 Proteins)) by metformin blocks Il4 (show IL4 Proteins)-dependent induction of Cox1 and blocks macrophage polarization/activation. (Il4 (show IL4 Proteins) = interleukin-4 (show IL4 Proteins); Cox1 = cyclooxygenase 1; Ampk (show PRKAA1 Proteins) = AMP-activated protein kinase (show PRKAA2 Proteins))
Specific inhibition of PGE2 synthesis by targeting mPGES-1 (show PTGES Proteins) may weaken host defense against bacterial infections.
Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (show YWHAZ Proteins), lipoxygenase and cyclooxygenase.
role of cyclooxygenase-1 and -2 in endothelium-dependent contraction of atherosclerotic mouse abdominal aortas
Suggest the expression of COX-1 and COX-2 in the urothelium protects bladder damage from radiation.
COX-1 inhibitor SC-560 has a protective effect on the thromboxane A2-mediated decrease in renal function in response to endotoxin.
Expression of COX-1 is essential for the protection of liver against chemical-induced hepatotoxicity and required for hepatic homeostatic maintenance.
Data suggest that multitarget FAAH (show FAAH Proteins)/Cox (show CPOX Proteins) blockade may provide a transformative approach to inflammatory bowel disease (IBD) and other pathologies in which fatty acid amide hydrolase (show FAAH Proteins)/cyclooxygenases (FAAH (show FAAH Proteins), Cox-1, and Cox-2) are overactive.
In arteries from non-insulin (show INS Proteins)-dependent diabetic mice, COX-1 remains a major contributor to the endothelial PGI2 (show PTGIR Proteins) synthesis that evokes vasoconstrictor activity under the pathological condition.
there was no expression of COX-1, either mRNA or protein, on any day of the estrous cycle
Results suggested that in Chinese Han patients with stroke taking aspirin for secondary prevention, PTGS1 polymorphisms may increase the risk of poor functional outcomes and this effect may be modulated by the smoking status. PTGS1 gene-smoking interaction might in part reflect the heterogeneity in the prognosis of patients treated with aspirin.
analysis of co-existing variants in both F8 and PTGS-1 genes in a three-generation pedigree of hemophilia A; the PTGS-1 variant was associated with specific functional defects in the arachidonic acid pathway and more severe hemorrhage.
Data suggest expression of PTGS1 in colon is significantly correlated with expression of PTGS2 (show PTGS2 Proteins), PTGES1, PTGER2 (show PTGER2 Proteins), and PTGER4 (show PTGER4 Proteins); this study was conducted in individuals at high risk for colon cancer treated with Mediterranean diet versus a Healthy Eating diet for prevention of colon cancer. (PG = prostaglandin; PTGS2 (show PTGS2 Proteins) = PG-endoperoxide synthase 2; PTGES1 = PGE (show LIPF Proteins) synthase protein; PTGER2 (show PTGER2 Proteins) = PGE (show LIPF Proteins) receptor 2; PTGER4 (show PTGER4 Proteins) = PGE (show LIPF Proteins) receptor 4)
Panax quinquefolium saponin attenuated HUVEC apoptosis and improved the dual antiplatelet-mediated reduction of platelet adhesion to injured HUVECs and the underlying mechanisms may be associated with PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and COX (show COX8A Proteins) pathways.
The interactions of COX (show COX8A Proteins)-1of rs3842787 and cox-2 of rs20417 were associated with aspirin resistance of stroke.
We provide the first report that pro-angiogenic genes PECAM1 (show PECAM1 Proteins), PTGS1, FGD5 (show FGD5 Proteins), and MCAM (show MCAM Proteins) may play a vital role in pathological dermal angiogenesis disorders of psoriasis.
a new neutrophil-activating platelet-derived lipid generated by COX-1 is presented that can activate or prime human neutrophils, suggesting a role in innate immunity and acute inflammation.
Seminal COX-1 is over-expressed in infertile oligoasthenoteratozoospermic (OAT (show OAT Proteins)) men with varicocele (Vx) compared with fertile men with/without and infertile OAT (show OAT Proteins) men without Vx being associated with oxidative stress, Vx grade and Vx laterality.
In Indian peptic ulcer hemorrhage patients, those with Cox-1 A842G polymorphisms tended to have less gastric ulcers among those with the A842G/C50T polymorphism.
Brain death increases the expression of COX-1 and COX-2 (show PTGS2 Proteins) mRNA in the renal medulla
Endometrial prostaglandin-endoperoxide synthase 1 (PTGS1) mRNA expression increased 2- to 3-fold after Day 10 of the estrous cycle and pregnancy, whereas PTGS2 (show PTGS2 Proteins) mRNA expression increased 76-fold between Days 5 and 15 of the estrous cycle and pregnancy.
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants.
, prostaglandin G/H synthase 1
, prostaglandin G/H synthase and cyclooxygenase
, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
, PGH synthase 1
, PHS 1
, prostaglandin H2 synthase 1
, prostaglandin-endoperoxide synthase 1
, cyclooxygenase 1
, cyclooxygenase 3
, prostaglandin endoperoxide synthase