anti-Protease, serine, 8 (PRSS8) Antibodies

PRSS8 encodes a trypsinogen, which is a member of the trypsin family of serine proteases. Additionally we are shipping Protease, serine, 8 Kits (40) and Protease, serine, 8 Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PRSS8 5652 Q16651
PRSS8 192107 Q9ES87
PRSS8 76560  
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Top anti-Protease, serine, 8 Antibodies at antibodies-online.com

Showing 10 out of 101 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PRSS8 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Jurkat cell lysate WB Suggested Anti-PRSS8  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated WB   200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated WB PRSS8 Antibody (Center) (ABIN658128) western blot analysis in MDA-MB453 cell line lysates (35 µg/lane). This demonstrates the PRSS8 antibody detected the PRSS8 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC, WB ABIN6273068 at 1/100 staining Mouse colon tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of A2780 cells, using PRSS8 antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: Prostasin/Prss8 Antibody [NBP1-31592] - Sample(30 ug whole cell lysate) A:HeLa S3 B:Raji 10% SDS PAGE, antibody diluted at 1:1000. 100 μL Log in to see 8 to 11 Days
$516.98
Details
Guinea Pig Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), ELISA Immunochemical staining of human PRSS8 in human kidney with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Immunochemical staining of human PRSS8 in human lung with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). 100 μg Log in to see 14 to 16 Days
$218.90
Details
Human Mouse Un-conjugated IP, ELISA, WB Immunoprecipitation of PRSS8 transfected lysate using anti-PRSS8 monoclonal antibody and Protein A Magnetic Bead , and immunoblotted with PRSS8 MaxPab rabbit polyclonal antibody. PRSS8 monoclonal antibody (M11A), clone 3C4. Western Blot analysis of PRSS8 expression in HepG2. 200 μL Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample(30 ug whole cell lysate) A:HeLa S3, B:Raji , 10% SDS PAGE antibody diluted at 1:1000 IHC-P Image Prostasin antibody [N1C2] detects Prostasin protein at cytosol on Ca922 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded Ca922 xenograft. Prostasin antibody [N1C2] , dilution: 1:250. 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti PRSS8 Polyclonal Antibody (ABIN761891), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human kidney labeled with Anti-PRSS8 Polyclonal Antibody, Unconjugated (ABIN761891) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$317.90
Details

Top referenced anti-Protease, serine, 8 Antibodies

  1. Human Polyclonal PRSS8 Primary Antibody for IHC, IHC (p) - ABIN441590 : Sherman-Baust, Becker, Wood Iii, Zhang, Morin: Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin, paclitaxel, or doxorubicin. in Journal of ovarian research 2012 (PubMed)

More Antibodies against Protease, serine, 8 Interaction Partners

Human Protease, serine, 8 (PRSS8) interaction partners

  1. limited role for HAI-2 in the inhibition of matriptase and prostasin is the result of its primarily intracellular localization in basal and spinous layer keratinocytes, which probably prevents the Kunitz inhibitor from interacting with active prostasin or matriptase

  2. PRSS8 was downregulated in glioma tissues.PRSS8 role in the glioma cell proliferation, migration, and invasion.

  3. PRSS8 acts as a tumor suppressor in colorectal cancer

  4. Data show that PRSS8 was reduced in esophageal squamous cell carcinomas (ESCC) tissues and the reduction of PRSS8 was associated with poor differentiation and shorter survival time.

  5. Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 and IL-13, down-regulates matriptase as well as prostasin through phosphorylation of the transcriptional regulator STAT6

  6. PRSS8 may serve as a tumour suppressor in hepatocellular carcinoma progression.

  7. Overexpression of PRSS8 mRNA and high levels of prostasin in multiple subtypes of early stage ovarian tumors may provide clinical biomarkers for early detection of ovarian cancer.

  8. It is concluded that prostasin protein level change is less likely to be causally involved in placental dysfunction in preeclampsia.

  9. In urinary exosomes, NCC and prostasin had a diurnal pattern parallel to ADH and aquaporin 2, confirming that, in healthy subjects, both prostasin and NCC relate to water balance.

  10. Polymorphism of the prostasin gene is closely associated with poor pregnancy outcomes of early-onset severe preeclampsia.

  11. Prostasin regulate the Lin28/Let-7 loop in ovarian cancer cells.

  12. The higher frequency of C allele of prostasin gene at rs12597511 is associated with severe preeclampsia.

  13. Prostasin repress cancer cells and contribute to chemoresistance by modulating the CASP/PAK2-p34/actin pathway.

  14. Our study suggested that Axl and prostasin expression may be closely related to carcinogenesis, metastasis, and prognosis of ovarian adenocarcinoma.

  15. urinary prostasin correlates with the aldosterone to renin ratio, and it is physiologically modulated by natriuresis in normotensive individuals

  16. prostasin is a non-enzymatic co-factor for matriptase activation

  17. Prostasin requires expression of endogenous matriptase to stimulate barrier formation since matriptase depletion by siRNA silencing abrogates prostasin barrier-forming activity.

  18. Essential hypertension in Xinjiang Kazakhs is not associated with the 2827C>T polymorphism in the prostasin gene.

  19. prostasin is present, mature and active on the apical surface of wild-type and cystic fibrosis bronchial epithelial cells

  20. Study does not provide evidence of a major role of prostasin variation in blood pressure modulation.

Mouse (Murine) Protease, serine, 8 (PRSS8) interaction partners

  1. Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 and IL-13, down-regulates matriptase as well as prostasin through phosphorylation of the transcriptional regulator STAT6

  2. a proteolysis-dependent function of activated prostasin in hair follicles, dependent on zymogen conversion by matriptase.

  3. The claudin-4-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1).

  4. HAI-1 regulates the activity of activated matriptase, whereas HAI-2 has an essential role in regulating prostasin-dependent matriptase zymogen activation.

  5. a novel inhibitory interaction between CAP1/Prss8 and nexin-1, opening the search for specific CAP1/Prss8 antagonists that are independent of its catalytic activity

  6. Data indicate that liver-specific serine protease prostasin (PRSS8) knockout (LKO) mice develop insulin resistance associated with the increase in hepatic Toll-like receptor 4 (TLR4).

  7. Data indicate that serine protease prostasin (CAP1/PRSS8) supports terminal epidermal differentiation through a non-catalytic mechanism.

  8. mutations in Prss8 restored placentation and normal development of HAI-1-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2-deficient embryos.

  9. Mutations of the serine protease CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity.

  10. The T to A mutation at residue 170 (Val to Asp) in Prss8 is responsible for the mutant frizzy (fr) phenotype.

  11. Deficiency of CAP1/Prss8 in alveolar epithelial cells induced in vitro a 40% decrease in epithelial sodium channel-mediated sodium currents.

  12. 546 backcross progeny were typed for linked markers to position fr centromeric of Fgfr2, between D7Csu5 and D7Mit165; an interval that contains only 2.7 Mb and fewer than 70 genes

  13. conditional allelle mutations at Prss8 can be generated by Cre- and FLP-mediated recombination

  14. CAP1/Prss8 expression in the epidermis is crucial for the epidermal permeability barrier and is, thereby, indispensable for postnatal survival.

  15. mutations in conserved residues of mCAP2 located in two protein-protein interacting domains significantly modulated ENaC activation

  16. findings demonstrate that prostasin is expressed in bladder epithelium; expression is downregulated during inflammation produced by intraperitoneal LPS injection; prostasin may play a role in bladder inflammatory response by modulating cytokine signaling

  17. Results suggest that cell-specific Gpld1- or peptidase-dependent pathways for prostasin secretion may control prostasin functions in a tissue-specific manner.

  18. Results indicate that PN-1 could have a natriuretic role by inhibiting prostasin activity. Aldosterone and TGF-beta reciprocally regulate the expression of PN-1. PN-1 could represent a new factor that contributes to regulation of ENaC activity.

  19. matriptase acts upstream of prostasin in a zymogen activation cascade that regulates terminal epidermal differentiation and is required for prostasin zymogen activation

Protease, serine, 8 (PRSS8) Antigen Profile

Protein Summary

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.

Gene names and symbols associated with PRSS8

  • protease, serine 8 (PRSS8) antibody
  • protease, serine, 8 (Prss8) antibody
  • protease, serine 8 (prostasin) (Prss8) antibody
  • protease, serine, 8 (PRSS8) antibody
  • 2410039E18Rik antibody
  • AI313909 antibody
  • C79772 antibody
  • CAP1 antibody
  • fr antibody
  • mCAP1 antibody
  • prostasin antibody

Protein level used designations for PRSS8

channel-activating protease 1 , prostasin , serine protease 8 , channel activating protease 1

GENE ID SPECIES
5652 Homo sapiens
192107 Rattus norvegicus
613506 Bos taurus
76560 Mus musculus
102148278 Equus caballus
102157328 Canis lupus familiaris
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