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PRSS8 encodes a trypsinogen, which is a member of the trypsin family of serine proteases.
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Human Polyclonal PRSS8 Primary Antibody for IHC, IHC (p) - ABIN441590
Sherman-Baust, Becker, Wood Iii, Zhang, Morin: Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin, paclitaxel, or doxorubicin. in Journal of ovarian research 2012
limited role for HAI-2 (show SPINT2 Antibodies) in the inhibition of matriptase (show ST14 Antibodies) and prostasin is the result of its primarily intracellular localization in basal and spinous layer keratinocytes, which probably prevents the Kunitz inhibitor from interacting with active prostasin or matriptase (show ST14 Antibodies)
PRSS8 was downregulated in glioma tissues.PRSS8 role in the glioma cell proliferation, migration, and invasion.
PRSS8 acts as a tumor suppressor in colorectal cancer
Data show that PRSS8 was reduced in esophageal squamous cell carcinomas (ESCC) tissues and the reduction of PRSS8 was associated with poor differentiation and shorter survival time.
Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 (show IL4 Antibodies) and IL-13 (show IL13 Antibodies), down-regulates matriptase (show ST14 Antibodies) as well as prostasin through phosphorylation of the transcriptional regulator STAT6 (show STAT6 Antibodies)
PRSS8 may serve as a tumour suppressor in hepatocellular carcinoma progression.
Overexpression of PRSS8 mRNA and high levels of prostasin in multiple subtypes of early stage ovarian tumors may provide clinical biomarkers for early detection of ovarian cancer.
It is concluded that prostasin protein level change is less likely to be causally involved in placental dysfunction in preeclampsia.
In urinary exosomes, NCC (show SLC12A3 Antibodies) and prostasin had a diurnal pattern parallel to ADH (show AVP Antibodies) and aquaporin 2 (show AQP2 Antibodies), confirming that, in healthy subjects, both prostasin and NCC (show SLC12A3 Antibodies) relate to water balance.
Polymorphism of the prostasin gene is closely associated with poor pregnancy outcomes of early-onset severe preeclampsia.
a proteolysis-dependent function of activated prostasin in hair follicles, dependent on zymogen conversion by matriptase (show ST14 Antibodies).
The claudin-4 (show CLDN4 Antibodies)-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1).
HAI-1 (show SPINT1 Antibodies) regulates the activity of activated matriptase (show ST14 Antibodies), whereas HAI-2 (show SPINT2 Antibodies) has an essential role in regulating prostasin-dependent matriptase (show ST14 Antibodies) zymogen activation.
a novel inhibitory interaction between CAP1/Prss8 and nexin-1 (show SERPINE2 Antibodies), opening the search for specific CAP1/Prss8 antagonists that are independent of its catalytic activity
Data indicate that liver-specific serine protease (show F2 Antibodies) prostasin (PRSS8) knockout (LKO) mice develop insulin (show INS Antibodies) resistance associated with the increase in hepatic Toll-like receptor 4 (TLR4 (show TLR4 Antibodies)).
Data indicate that serine protease (show F2 Antibodies) prostasin (CAP1/PRSS8) supports terminal epidermal differentiation through a non-catalytic mechanism.
mutations in Prss8 restored placentation and normal development of HAI-1 (show SPINT1 Antibodies)-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2 (show SPINT2 Antibodies)-deficient embryos.
Mutations of the serine protease (show F2 Antibodies) CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC (show SCNN1A Antibodies) activity.
The T to A mutation at residue 170 (Val to Asp (show C3 Antibodies)) in Prss8 is responsible for the mutant frizzy (fr) phenotype.
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.
channel-activating protease 1
, serine protease 8
, channel activating protease 1
, protease, serine, 8