Protein Arginine Methyltransferase 1 Proteins (PRMT1)

PRMT1 encodes a member of the protein arginine N-methyltransferase (PRMT) family. Additionally we are shipping PRMT1 Antibodies (123) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PRMT1 3276 Q99873
Rat PRMT1 PRMT1 60421 Q63009
PRMT1 15469 Q9JIF0
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Top PRMT1 Proteins at

Showing 10 out of 28 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Escherichia coli (E. coli) Human Un-conjugated   50 μg 2 to 3 Days
Escherichia coli (E. coli) Mouse Un-conjugated   50 μg 2 to 3 Days
Escherichia coli (E. coli) Human GST tag 50 μg 13 to 16 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Escherichia coli (E. coli) Human His-MBP 100 μg 11 to 12 Days
Escherichia coli (E. coli) Human GST tag 100 μg 11 Days
Escherichia coli (E. coli) Mouse His-MBP 100 μg 11 to 12 Days

PRMT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , , ,
Mouse (Murine) ,
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Top referenced PRMT1 Proteins

  1. Human PRMT1 Protein expressed in HEK-293 Cells - ABIN2729657 : Tikhanovich, Kuravi, Artigues, Villar, Dorko, Nawabi, Roberts, Weinman: Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling. in The Journal of biological chemistry 2015 (PubMed)

More Proteins for Protein Arginine Methyltransferase 1 (PRMT1) Interaction Partners

Human Protein Arginine Methyltransferase 1 (PRMT1) interaction partners

  1. CBX7 and PRMT1 contribute to regulate E-cadherin expression through several mechanisms.

  2. overexpressing ZEB1 reversed the antitumor effects of PRMT1 downregulation in Pancreatic cancer (PC) cells. PRMT1 was aberrantly upregulated in PC. PRMT1 inhibition, possibly inversely acting through ZEB1, might be an effective molecular intervention to inhibit PC growth and invasion.

  3. Methionine is required for Wnt-induced endolysosomal activitythrough the generation of SAM, which fosters the sequestration ofPRMT1 and GSK3 inside late endosomes/MVBs.

  4. 58 novel PRMT1 transcripts were identified.

  5. Study was the first to demonstrate that PRMT1 levels were reduced by propionate treatment in HCT116 colon cancer cells and that downregulation of PRMT1 induced cell apoptosis. Downregulation of PRMT1 expression by propionate, induced apoptosis by inhibiting p70 S6 kinase phosphorylation.

  6. Study reports the interaction of PRMT1 with an extensive panel of polyRGG-box substrates showing that substrate aromatics (Phe or Tyr) are either neutral or promote binding to PRMT1, while sufficient numbers of substrate Asp residues impairs binding/methylation.

  7. Target identification reveals protein arginine methyltransferase 1 is a potential target of phenyl vinyl sulfone and its derivatives.

  8. GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1.

  9. Study characterizes a novel splicing isoform of PRMT1 that correlates with cellular malignancy. This isoform lacks the dimerization arm of the enzyme, and is catalytically inactive, but able to bind substrates, and blocks cells in the G1 phase of the cell cycle.

  10. the abnormal stable complex of FUS-R521C/PRMT1/Nd1-L mRNA could contribute to neurodegeneration upon oxidative stress.

  11. Important roles of PRMT1 in progression of gastric cancer. Given the dual functions of PRMT1, it is as a potential drug target of gastric cancer with extreme caution.

  12. Mitochondrial Ca(2+) uptake is controlled by protein arginine methyl transferase 1 that asymmetrically methylates MICU1, resulting in decreased Ca(2+) sensitivity. UCP2/3 normalize Ca(2+) sensitivity of methylated MICU1 and, thus, re-establish mitochondrial Ca(2+) uptake activity.

  13. High-PRMT1 expression is associated with resistance to cetuximab in triple-negative breast cancer.

  14. a significant role for PRMT1 in HCC progression and metastasis in vitro and in vivo via STAT3 signalling pathway activation. PRMT1 may be a potential novel prognostic biomarker and new therapeutic target for hepatocellular carcinoma.

  15. High PRMT1 expression is associated with head and neck and oral cancer.

  16. TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1

  17. data collectively suggest that silencing of PRMT1 exerts anti-catabolic and anti-inflammatory effects on IL-1beta-induced chondrocytes via suppressing the Gli-1 mediated Hedgehog signaling pathway, indicating that PRMT1 plays a critical role in OA development and serves as a promising therapeutic target for OA.

  18. Deacetylation on both K200 and K205 by Sirtuin 1 (Sirt1) and acetylation of p300 (EP300) on K205 collaboratively prepare the motif for SCF(Fbxl17) binding thereby triggering PRMT1 protein degradation.

  19. PRMT1 has a role in regulating MYCN in neuroblastoma

  20. Analysis of deletion constructs of SERBP1 showed that the C-terminal third of the SERBP1 protein, which contains one of its two substrate sites for protein arginine N-methyltransferase 1 (PRMT1), is necessary and sufficient for it to interact with RACK1

Zebrafish Protein Arginine Methyltransferase 1 (PRMT1) interaction partners

  1. prmt8 may play important roles non-overlapping with prmt1 in embryonic and neural development depending on its specific N-terminus.

  2. prmt1 gene is actively and ubiquitously expressed at both RNA and protein levels at the early developmental stages of zebrafish.

Xenopus laevis Protein Arginine Methyltransferase 1 (PRMT1) interaction partners

  1. PRMT1 functions transiently as a coactivator in thyroid hormone (T3) receptor (TR)-mediated transcription by enhancing TR-T3 response element binding and further suggest that PRMT1 has tissue-specific roles in regulating the rate of metamorphosis.

Pig (Porcine) Protein Arginine Methyltransferase 1 (PRMT1) interaction partners

  1. Results suggest that part of the type I arginine methyltransferases in brains, mainly PRMT1, are sequestered in an inactive form as they associated with membranes or large subcellular complexes.

Mouse (Murine) Protein Arginine Methyltransferase 1 (PRMT1) interaction partners

  1. PRMT1 became activated upon IGF-1 stimulation.

  2. we disrupted PRMT1 function in neural crest cell (NCC)-derived tissues using Wnt1-Cre. NCC-specific deletion of Prmt1 caused cleft palate and craniofacial malformations, including reductions in the size of the head, mandible, and tongue. In the Prmt1-deficient mice, palate mesenchymal cell proliferation was dramatically reduced, and palatal shelves failed to reach the midline, resulting in a complete cleft palate phenotyp

  3. PRMT1 thus regulates Th17 differentiation by controlling the reciprocal recruitment of STAT3 and STAT5.

  4. PRMT1 regulates the transcription activity of NF-kappaB by directly interacting with it in RANKL-treated bone marrow-derived macrophages.

  5. Developmental changes in the placental expression of PRMT1 and in protein arginine methylation status during pregnancy.

  6. We further determined that Prmt1 depletion resulted in significant downregulation of Msx1 in calvaria-derived preosteoblast and primordium of frontal bone and mandible. Our study reveals critical roles of PRMT1 in the formation of CNC-derived craniofacial bones and suggests that Prmt1 is an upstream regulator of Msx1 in craniofacial bone development

  7. Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation

  8. PRMT activity is selectively augmented during the initial activation of exercise-induced skeletal muscle remodeling in vivo.

  9. PRMT1 inhibition, such as induced by alcohol, may result in epigenetic changes leading to loss of Hnf4alpha. This effect may contribute to alcohol's ability to promote liver tumors

  10. the present study increases our understanding of PRMT1, -4, and -5 biology during the plasticity of skeletal muscle development. Our results provide evidence for a role of PRMT1, via a mitochondrially mediated mechanism, in driving the muscle differentiation program.

  11. lipotoxicity-induced PRMT1 expression promotes endoplasmic reticulum stress-mediated mesangial cell apoptosis.

  12. PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity.

  13. PRMT1 inhibition prevents gastric cancer progression by downregulating eIF4E and targeting type II PRMT5.

  14. Low Prmt1 expression is associated with osteosarcoma.

  15. Collectively, the authors propose that Prmt1-dependent facilitation of KCNQ-phosphatidylinositol-4,5-bisphosphate interaction underlies the positive regulation of KCNQ activity by arginine methylation, which may serve as a key target for prevention of neuronal hyperexcitability and seizures.

  16. Results identify a key molecular mechanism by which the BTG2-PRMT1 module regulates pre-B cell differentiation and inhibits pre-B cell leukemogenesis.

  17. Data, including data from studies in cells from knockout mice, suggest that Prmt1 activity was necessary for c-Myc binding to acetyltransferase p300 in myeloid cells; Prmt1 inhibition decreases p300 recruitment to c-Myc target promoters and increased Hdac1 recruitment. [Prmt1, protein arginine N-methyltransferase 1; c-Myc = Proto-Oncogene Proteins c-myc; Hdac1 = histone deacetylase 1]

  18. PRMT1-dependent regulation of macrophage PPARgamma expression contributes to the infection susceptibility in PRMT1 knock-out mice

  19. These findings suggest that arginine methylation by PRMT1 regulates muscle stem cell fate through the Eya1/Six1/MyoD axis.

  20. PRMT1 is necessary for lymphocyte functions in vivo.

PRMT1 Protein Profile

Protein Summary

This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.

Gene names and symbols associated with PRMT1

  • protein arginine methyltransferase 1A (PRMT1A)
  • protein arginine N-methyltransferase-1 (prm-1)
  • protein arginine N-methyltransferase 1 (EDI_007800)
  • protein arginine N-methyltransferase 1 (Smp_029240.3)
  • protein arginine methyltransferase 1 (prmt1)
  • protein arginine N-methyltransferase (PRMT1)
  • protein arginine methyltransferase (prmt1)
  • protein arginine methyltransferase 1 (PRMT1)
  • protein arginine methyltransferase 1 S homeolog (prmt1.S)
  • protein arginine methyltransferase 1 (Prmt1)
  • protein arginine N-methyltransferase 1 (Prmt1)
  • 3E10 protein
  • 6720434D09Rik protein
  • anm1 protein
  • ATPRMT1A protein
  • AW214366 protein
  • DDBDRAFT_0183976 protein
  • DDBDRAFT_0235399 protein
  • DDB_0183976 protein
  • DDB_0235399 protein
  • DKFZp459J1326 protein
  • F6F22.30 protein
  • F6F22_30 protein
  • fb39h07 protein
  • hcp1 protein
  • Hrmt1l2 protein
  • ir1b4 protein
  • Mrmt1 protein
  • PRMT1 protein
  • protein arginine methyltransferase 1A protein
  • wu:fb39h07 protein
  • xPRMT1 protein
  • xPRMT1b protein
  • zf1 protein
  • zgc:66201 protein

Protein level used designations for PRMT1

protein arginine N-methyltransferase 1 , protein arginine methyltransferase 1 , protein arginine N-methyltransferase , HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2 , heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2 , histone-arginine N-methyltransferase PRMT1 , interferon receptor 1-bound protein 4 , HMT1 hnRNP methyltransferase-like 2 , histone-arginine N-methyltransferase PRMT1-A , protein arginine N-methyltransferase 1-A , heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 , arginine N-methyltransferase 1

816486 Arabidopsis thaliana
3880059 Neurospora crassa OR74A
5880968 Entamoeba dispar SAW760
8347013 Schistosoma mansoni
100194598 Salmo salar
5728909 Chlamydomonas reinhardtii
8628232 Dictyostelium discoideum AX4
100052097 Equus caballus
100173232 Pongo abelii
3276 Homo sapiens
321974 Danio rerio
399121 Xenopus laevis
476411 Canis lupus familiaris
520388 Bos taurus
60421 Rattus norvegicus
100286877 Sus scrofa
15469 Mus musculus
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