anti-Protein C Receptor, Endothelial (PROCR) Antibodies

The protein encoded by PROCR is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. Additionally we are shipping PROCR Kits (73) and PROCR Proteins (37) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PROCR 10544 Q9UNN8
PROCR 362248 Q4V8I1
PROCR 19124 Q64695
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Top anti-PROCR Antibodies at antibodies-online.com

Showing 10 out of 157 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Western Blot (WB) analysis of Rat barin lysis using CD201 antibody. 100 μL Available
$363.46
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to PROCR on formalin-fixed paraffin-embedded human malignant lymphoma, diffuse large B tissue. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to PROCR on HeLa cell. [antibody concentration 10 ug/ml] 100 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL 6 to 8 Days
$484.00
Details
Rat Rabbit Un-conjugated ICC, IHC, WB Figure. DAB staining on IHC-P; Samples: Rat Testis Tissue. 100 μg 15 to 18 Days
$342.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of CD201 antibody (Center) (ABIN389416) in T47D cell line lysates (35 µg/lane). CD201 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma with CD201 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL 10 to 11 Days
$385.00
Details
Cow Rabbit Un-conjugated WB   200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of EPCR/CD201 expression in A549 whole cell lysates (lane 1). EPCR/CD201 at 46KD, 52KD was detected using rabbit anti- EPCR/CD201 Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method 100 μg 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ELISA, IHC (p) Immunochemical staining of human PROCR in human kidney with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to endothelial cells. Immunochemical staining of human PROCR in human lung with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to endothelial cells. 100 μL 14 to 16 Days
$247.82
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg 15 to 18 Days
$316.00
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure. DAB staining on IHC-P; Samples: Mouse Testis Tissue. 100 μg 15 to 18 Days
$324.00
Details

Top referenced anti-PROCR Antibodies

  1. Human Polyclonal PROCR Primary Antibody for CyTOF, FACS - ABIN4899324 : Ducros, Berthaut, Mirshahi, Faussat, Soria, Agarwal, Mirshahi: Aldosterone modifies hemostasis via upregulation of the protein-C receptor in human vascular endothelium. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 7 Pubmed References

  2. Human Monoclonal PROCR Primary Antibody for IF, IHC (p) - ABIN564600 : Lee, Ku, Bae: Emodin-6-O-?-D-glucoside down-regulates endothelial protein C receptor shedding. in Archives of pharmacal research 2013 (PubMed)
    Show all 6 Pubmed References

  3. Mouse (Murine) Polyclonal PROCR Primary Antibody for CyTOF, FACS - ABIN4899294 : Greineder, Chacko, Zaytsev, Zern, Carnemolla, Hood, Han, Ding, Esmon, Muzykantov: Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor. in PLoS ONE 2013 (PubMed)
    Show all 6 Pubmed References

  4. Human Monoclonal PROCR Primary Antibody for Func, FACS - ABIN2192007 : Dömötör, Benzakour, Griffin, Yule, Fukudome, Zlokovic: Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. in Blood 2003 (PubMed)
    Show all 5 Pubmed References

  5. Human Monoclonal PROCR Primary Antibody for Func, FACS - ABIN2192008 : Ye, Fukudome, Tsuneyoshi, Satoh, Tokunaga, Sugawara, Mizokami, Kimoto: The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries. in Biochemical and biophysical research communications 1999 (PubMed)
    Show all 5 Pubmed References

  6. Human Polyclonal PROCR Primary Antibody for WB - ABIN4270023 : Gera, Shavit-Stein, Bushi, Harnof, Shimon, Weiss, Golderman, Dori, Maggio, Finegold, Chapman: Thrombin and protein C pathway in peripheral nerve Schwann cells. in Neuroscience 2016 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal PROCR Primary Antibody for FACS - ABIN2689080 : Biguzzi, Merati, Liaw, Bucciarelli, Oganesyan, Qu, Gu, Fetiveau, Esmon, Mannucci, Faioni: A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function. in Thrombosis and haemostasis 2001 (PubMed)
    Show all 2 Pubmed References

  8. Human Polyclonal PROCR Primary Antibody for WB - ABIN523963 : Ku, Kim, Bae: Piperlonguminine downregulates endothelial protein C receptor shedding in vitro and in vivo. in Inflammation 2014 (PubMed)

  9. Human Monoclonal PROCR Primary Antibody for BP, FACS - ABIN269970 : Schut, Kirschbaum, Adelmeijer, de Groot, Lisman: In vitro uptake of recombinant factor VIIa by megakaryocytes with subsequent production of platelets containing functionally active drug. in British journal of haematology 2016 (PubMed)

More Antibodies against PROCR Interaction Partners

Human Protein C Receptor, Endothelial (PROCR) interaction partners

  1. biophysical analysis of a possible mode of ligand recognition by the EPCR via the involvement of phosphatidylcholine within its hydrophobic groove

  2. PROCR, but not THBD, polymorphisms are associated with early-onset ischemic stroke in young Caucasians. There were no PROCR or THBD associations in African-Americans.

  3. Plasma soluble EPCR was elevated in alpha-thalassemia intermedia.

  4. Recent studies provide a mechanistic basis to how EPCR contributes to PAR1-mediated biased signaling. EPCR may play a role in influencing a wide array of biological functions by binding to diverse ligands.

  5. PROCR H1 and H3 haplotypes were determined by genotyping 7014G/C and 1651C/G tag-polymorphisms, respectively. The PROCR H1 haplotype was less frequently found in antiphospholipid syndrome patients with arterial thrombosis, suggesting a protective effect of PROCR H1 against arterial thrombosis in these patients.

  6. this is the first comprehensive study of PROCR signaling in breast cancer cells, and its findings also shed light on the molecular mechanisms of PROCR in stem cells in normal tissue.

  7. The activation of PAR-1 on the cell surface of SGC7901 and AGS cells was significantly reduced after the knockdown of EPCR. By contrast, blockade of PAR-1 reduced the proliferation and migration of gastric cells in vitro

  8. analysis of DC8 and DC13 PfEMP1 variants reveals that Plasmodium falciparum-infected erythrocytes-endothelial protein C receptor interaction may be prevented by plasma components under physiological conditions

  9. Low EPCR expression is associated with meningococcal purpura fulminans.

  10. Our findings suggested that breast cancer patients with expression of PROCR is more prone to suffer from distant metastasis and bad clinical outcomes.

  11. Plasma levels of Ang2 were associated with markers of malaria severity and levels of var transcripts encoding P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) containing Cysteine Rich Inter Domain Region alpha1 (CIDRalpha1) domains predicted to bind Endothelial Protein C receptor (EPCR).

  12. The EPCR rs867186-GG genotype is associated with increased soluble protein, and it could mediate protection against severe malaria.

  13. The data indicate that EPCR can regulate p63, is associated with highly proliferative keratinocytes, and is a potential human epidermal stem cell marker.

  14. Analysis of a cohort of breast cancer patients revealed an association of high EPCR levels with adverse clinical outcome. Interestingly, EPCR knockdown did not affect cell growth kinetics in 2D but reduced cell growth in 3D cultures. EPCR silencing reduced primary tumor growth and secondary outgrowths at metastatic sites. EPCR via SPOCK1 confers a cell growth advantage in 3D promoting breast tumorigenesis and metastasis.

  15. analysis of renal endothelial PROCR expression and shedding during diabetic nephropathy

  16. EPCR occupancy recruits G-protein coupled receptor kinase 5, thereby inducing beta-arrestin-2 biased PAR1 signaling by both APC and thrombin. In

  17. EPCR polymorphisms may be associated with increased risk of sepsis, but this has no effect on the release of soluble EPCR in patients with sepsis.

  18. Elevated endothelium-related mediators (vWF, E-selectin and EPCR) appear to participate in the development of pancreatic necrosis and may be a potential indicator of overall prognosis.

  19. The results showed that AS-IV could significantly inhibit PMA-induced EPCR shedding.

  20. CORM-2 protects human umbilical vein endothelial cells from lipopolysaccharide-induced injury, by way of suppressing NF-kappaB activity, which downregulates TM and EPCR mRNAs. It also decreases MMP-2 expression and prevents the shedding of TM and EPCR from the surface of endothelial cells, so as to preserve their protective effect.

Mouse (Murine) Protein C Receptor, Endothelial (PROCR) interaction partners

  1. Leu8 is crucial for FVIIa-EPCR binding; this study characterizes its interaction in vivo in mice

  2. PROCR thus does not globally inhibit Th17 responses but could be targeted to selectively inhibit proinflammatory Th17 cells.

  3. Thrombin-PAR1 signaling, via nitric oxide and EPCR, promotes hematopoietic stem cell (HSC) mobilization. aPC-EPCR-PAR1 signaling promotes HSC retention in bone marrow.

  4. impaired EPCR/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis

  5. sPLA2-V plays a thrombogenic role by impairing the ability of EPCR to promote protein C activation.

  6. HSCs appear to maintain expression of CD201 after hematopoietic injury when Kit expression is downregulated.

  7. The protein C receptor (ProcR; EPCR) was required for the normal in vivo and in vitro induction of lipopolysaccharide (LPS)-regulated gene expression.

  8. Data indicate that endothelial protein C receptor (EPCR) binding enhances FVIIa hemostatic activity in vivo.

  9. knock-outs display diminished inflammatory immunity, enhanced blood coagulation as well as reduced bacterial growth in pneumococcal pneumonia and sepsis

  10. protein C receptor (Procr), a novel Wnt target in the mammary gland, marks a unique population of multipotent mouse mammary stem cells

  11. FVIIa binding to EPCR leads to a barrier protective effect in vivo

  12. Piperlonguminine might have potential as an anti-sEPCR shedding reagent against sepsis-mediated EPCR shedding.

  13. FVIIa binding to EPCR on the endothelium facilitates the transport of FVIIa from circulation to extravascular tissues where TF resides

  14. mineralocorticoid receptor activation has a role in enhancing endothelial protein C receptor and decreases vascular thrombosis in mice

  15. EPCR and APC play a limited role in the host response during pulmonary tuberculosis.

  16. Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition.

  17. Study demonstrates an important protective role for EPCR in vivo against vascular leakage during inflammation and suggests that EPCR-dependent vascular protection is organ-specific.

  18. FFAs inhibit TM-EPCR-Protein C system in endothelial cells through activating JNK signaling, which may be a mechanism for the prothrombotic state in metabolic syndrome.

  19. data indicate that it is possible to overexpress EPCR at a sufficient level to provide protection against transplant-related thrombotic and inflammatory injury

  20. Letter: Endothelial cell protein C receptor does not appear to play a significant role in human factor VIIa clearance from plasma.

PROCR Antigen Profile

Protein Summary

The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.

Gene names and symbols associated with PROCR

  • protein C receptor (PROCR) antibody
  • protein C receptor (Procr) antibody
  • protein C receptor, endothelial (Procr) antibody
  • AI325044 antibody
  • Ccca antibody
  • Ccd41 antibody
  • Epcr antibody
  • PROCR antibody

Protein level used designations for PROCR

protein C receptor, endothelial (EPCR) , APC receptor , CD201 antigen , activated protein C receptor , cell cycle, centrosome-associated protein , centrocyclin , endothelial protein C receptor , endothelial cell protein C receptor , CD antigen CD201 , centrosomal protein CCD41 , endothelial cell protein C/activated protein C

GENE ID SPECIES
458198 Pan troglodytes
10544 Homo sapiens
362248 Rattus norvegicus
19124 Mus musculus
100731547 Cavia porcellus
654289 Sus scrofa
282005 Bos taurus
485848 Canis lupus familiaris
424867 Gallus gallus
101115814 Ovis aries
Selected quality suppliers for anti-PROCR (PROCR) Antibodies
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