Protein C Receptor, Endothelial Proteins (PROCR)

The protein encoded by PROCR is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. Additionally we are shipping PROCR Antibodies (152) and PROCR Kits (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PROCR 10544 Q9UNN8
PROCR 362248 Q4V8I1
PROCR 19124 Q64695
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Top PROCR Proteins at

Showing 10 out of 36 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
Human Cells Human His tag   50 μg 4 Days
Human Cells Human His tag 50 μg 14 to 16 Days
Human Cells Mouse Fc Tag 50 μg 14 to 16 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
HEK-293 Cells Human His tag Human PROCR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg 2 to 3 Days
Escherichia coli (E. coli) Human His tag 100 μg 13 to 16 Days

PROCR Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , , ,
Rat (Rattus) , ,

Mouse (Murine) , ,
, ,

Top referenced PROCR Proteins

  1. Human PROCR Protein expressed in Wheat germ - ABIN1316360 : Fink, Busch, Bourgeois, Schwarz, Wolf, Zirlik, Peter, Bode, von Zur Muhlen: Mac-1 directly binds to the endothelial protein C-receptor: a link between the protein C anticoagulant pathway and inflammation? in PLoS ONE 2013 (PubMed)
    Show all 3 Pubmed References

More Proteins for Protein C Receptor, Endothelial (PROCR) Interaction Partners

Human Protein C Receptor, Endothelial (PROCR) interaction partners

  1. The acquisition of antibodies against EPCR-binding cysteine-rich interdomain region alpha1 domains of PfEMP1 after a severe malaria episode suggest that EPCR-binding PfEMP1 may have a role in the pathogenesis of severe malaria in Papua New Guinea.

  2. single nucleotide polymorphisms of endothelial protein C receptor are associated with Kawasaki disease susceptibility in a Chinese Han children

  3. biophysical analysis of a possible mode of ligand recognition by the EPCR via the involvement of phosphatidylcholine within its hydrophobic groove

  4. PROCR, but not THBD, polymorphisms are associated with early-onset ischemic stroke in young Caucasians. There were no PROCR or THBD associations in African-Americans.

  5. Plasma soluble EPCR was elevated in alpha-thalassemia intermedia.

  6. Recent studies provide a mechanistic basis to how EPCR contributes to PAR1-mediated biased signaling. EPCR may play a role in influencing a wide array of biological functions by binding to diverse ligands.

  7. PROCR H1 and H3 haplotypes were determined by genotyping 7014G/C and 1651C/G tag-polymorphisms, respectively. The PROCR H1 haplotype was less frequently found in antiphospholipid syndrome patients with arterial thrombosis, suggesting a protective effect of PROCR H1 against arterial thrombosis in these patients.

  8. this is the first comprehensive study of PROCR signaling in breast cancer cells, and its findings also shed light on the molecular mechanisms of PROCR in stem cells in normal tissue.

  9. The activation of PAR-1 on the cell surface of SGC7901 and AGS cells was significantly reduced after the knockdown of EPCR. By contrast, blockade of PAR-1 reduced the proliferation and migration of gastric cells in vitro

  10. analysis of DC8 and DC13 PfEMP1 variants reveals that Plasmodium falciparum-infected erythrocytes-endothelial protein C receptor interaction may be prevented by plasma components under physiological conditions

  11. Low EPCR expression is associated with meningococcal purpura fulminans.

  12. Our findings suggested that breast cancer patients with expression of PROCR is more prone to suffer from distant metastasis and bad clinical outcomes.

  13. Plasma levels of Ang2 were associated with markers of malaria severity and levels of var transcripts encoding P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) containing Cysteine Rich Inter Domain Region alpha1 (CIDRalpha1) domains predicted to bind Endothelial Protein C receptor (EPCR).

  14. The EPCR rs867186-GG genotype is associated with increased soluble protein, and it could mediate protection against severe malaria.

  15. The data indicate that EPCR can regulate p63, is associated with highly proliferative keratinocytes, and is a potential human epidermal stem cell marker.

  16. Analysis of a cohort of breast cancer patients revealed an association of high EPCR levels with adverse clinical outcome. Interestingly, EPCR knockdown did not affect cell growth kinetics in 2D but reduced cell growth in 3D cultures. EPCR silencing reduced primary tumor growth and secondary outgrowths at metastatic sites. EPCR via SPOCK1 confers a cell growth advantage in 3D promoting breast tumorigenesis and metastasis.

  17. analysis of renal endothelial PROCR expression and shedding during diabetic nephropathy

  18. EPCR occupancy recruits G-protein coupled receptor kinase 5, thereby inducing beta-arrestin-2 biased PAR1 signaling by both APC and thrombin. In

  19. EPCR polymorphisms may be associated with increased risk of sepsis, but this has no effect on the release of soluble EPCR in patients with sepsis.

  20. Elevated endothelium-related mediators (vWF, E-selectin and EPCR) appear to participate in the development of pancreatic necrosis and may be a potential indicator of overall prognosis.

Mouse (Murine) Protein C Receptor, Endothelial (PROCR) interaction partners

  1. Epcr-transduced Mpl(-/-) hematopoietic stem cells enter quiescence earlier after transplantation than control-transduced Mpl(-/-) cells, and upregulated expression of the anti-apoptotic gene Bcl-xL.

  2. Leu8 is crucial for FVIIa-EPCR binding; this study characterizes its interaction in vivo in mice

  3. PROCR thus does not globally inhibit Th17 responses but could be targeted to selectively inhibit proinflammatory Th17 cells.

  4. Thrombin-PAR1 signaling, via nitric oxide and EPCR, promotes hematopoietic stem cell (HSC) mobilization. aPC-EPCR-PAR1 signaling promotes HSC retention in bone marrow.

  5. impaired EPCR/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis

  6. sPLA2-V plays a thrombogenic role by impairing the ability of EPCR to promote protein C activation.

  7. HSCs appear to maintain expression of CD201 after hematopoietic injury when Kit expression is downregulated.

  8. The protein C receptor (ProcR; EPCR) was required for the normal in vivo and in vitro induction of lipopolysaccharide (LPS)-regulated gene expression.

  9. Data indicate that endothelial protein C receptor (EPCR) binding enhances FVIIa hemostatic activity in vivo.

  10. knock-outs display diminished inflammatory immunity, enhanced blood coagulation as well as reduced bacterial growth in pneumococcal pneumonia and sepsis

  11. protein C receptor (Procr), a novel Wnt target in the mammary gland, marks a unique population of multipotent mouse mammary stem cells

  12. FVIIa binding to EPCR leads to a barrier protective effect in vivo

  13. Piperlonguminine might have potential as an anti-sEPCR shedding reagent against sepsis-mediated EPCR shedding.

  14. FVIIa binding to EPCR on the endothelium facilitates the transport of FVIIa from circulation to extravascular tissues where TF resides

  15. mineralocorticoid receptor activation has a role in enhancing endothelial protein C receptor and decreases vascular thrombosis in mice

  16. EPCR and APC play a limited role in the host response during pulmonary tuberculosis.

  17. Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition.

  18. Study demonstrates an important protective role for EPCR in vivo against vascular leakage during inflammation and suggests that EPCR-dependent vascular protection is organ-specific.

  19. FFAs inhibit TM-EPCR-Protein C system in endothelial cells through activating JNK signaling, which may be a mechanism for the prothrombotic state in metabolic syndrome.

  20. data indicate that it is possible to overexpress EPCR at a sufficient level to provide protection against transplant-related thrombotic and inflammatory injury

PROCR Protein Profile

Protein Summary

The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.

Gene names and symbols associated with PROCR

  • protein C receptor (PROCR)
  • protein C receptor (Procr)
  • protein C receptor, endothelial (Procr)
  • AI325044 protein
  • Ccca protein
  • Ccd41 protein
  • Epcr protein
  • PROCR protein

Protein level used designations for PROCR

protein C receptor, endothelial (EPCR) , APC receptor , CD201 antigen , activated protein C receptor , cell cycle, centrosome-associated protein , centrocyclin , endothelial protein C receptor , endothelial cell protein C receptor , CD antigen CD201 , centrosomal protein CCD41 , endothelial cell protein C/activated protein C

458198 Pan troglodytes
10544 Homo sapiens
362248 Rattus norvegicus
19124 Mus musculus
100731547 Cavia porcellus
654289 Sus scrofa
282005 Bos taurus
485848 Canis lupus familiaris
424867 Gallus gallus
101115814 Ovis aries
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