PROCR Protein (His tag)

Catalog No. ABIN7320123

Recombinant PROCR protein expressed in HEK-293 Cells.

Quick Overview for PROCR Protein (His tag) (ABIN7320123)

Target: PROCR (Protein C Receptor, Endothelial (PROCR))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 96 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This PROCR protein is labelled with His tag.

Purpose: Recombinant Mouse EPCR Protein (His Tag)

Sequence: Met 1-Ser 214

Characteristics: A DNA sequence encoding the mouse PROCR (Q64695) extracellular domain (Met 1-Ser 214) was expressed, with a C-terminal polyhistidine tag.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: PROCR (Protein C Receptor, Endothelial (PROCR))

Alternative Name: EPCR

Background:

Background: Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other. 

Synonym: AI325044;Ccca;Ccd41;Epcr

Molecular Weight: 23.7 kDa

UniProt: Q64695