PROCR Protein (Fc Tag)
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- Target See all PROCR Proteins
- PROCR (Protein C Receptor, Endothelial (PROCR))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This PROCR protein is labelled with Fc Tag.
- Purpose
- Recombinant Mouse EPCR Protein (Fc Tag)
- Sequence
- Met 1-Ser 214
- Characteristics
- A DNA sequence encoding the mouse PROCR (Q64695) extracellular domain (Met 1-Ser 214) was fused with the Fc region of human IgG1 at the C-terminus.
- Purity
- > 85 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product PROCR Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- PROCR (Protein C Receptor, Endothelial (PROCR))
- Alternative Name
- EPCR (PROCR Products)
- Synonyms
- PROCR Protein, CCCA Protein, CCD41 Protein, EPCR Protein, AI325044 Protein, Ccca Protein, Ccd41 Protein, Epcr Protein, protein C receptor Protein, protein C receptor, endothelial Protein, PROCR Protein, Procr Protein
- Background
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Background: Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other.
Synonym: AI325044;Ccca;Ccd41;Epcr
- Molecular Weight
- 49.3 kDa
- UniProt
- Q64695
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