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Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1.
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Human Polyclonal PGGT1B Primary Antibody for ELISA, WB - ABIN562193
Iguchi, Katsuno, Niwa, Yamada, Sone, Waza, Adachi, Tanaka, Nagata, Arimura, Watanabe, Kaibuchi, Sobue: TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases. in The Journal of biological chemistry 2009
Human Monoclonal PGGT1B Primary Antibody for IF, IHC (p) - ABIN562194
Lee, Chang, Trinh, Tu, White, Davies, Bergo, Fong, Lowry, Young: Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes. in Human molecular genetics 2010
our study showed, for the first time, that HIF-1alpha (show HIF1A Antibodies) was regulated by protein prenylation transferase GGTI and mediated the effect of GGTI on glioma cell migration and invasion
RNAi knockdown of GGTase-Ibeta inhibited invasion, disrupted F-actin organization and decreased the level of cofilin (show CFL1 Antibodies) in PC-3 (show PCSK1 Antibodies) cells.
results suggest that geranylgeranylation of RhoA (show RHOA Antibodies) is critical for cancer cell invasion
Targeting GGTase-I activates RHOA (show RHOA Antibodies) and leads to increased macrophage reverse cholesterol transport and reduced atherosclerosis development despite a significant increase in inflammation.
Both Fntb and Pggt1b are required for the homeostasis of skin keratinocytes.
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994
protein geranylgeranyltransferase type I, beta subunit
, geranylgeranyl transferase type I subunit beta
, geranylgeranyl transferase type-1 subunit beta
, geranylgeranyltransferase type I beta subunit
, type I protein geranyl-geranyltransferase subunit beta
, geranylgeranyltransferase type 1 beta
, geranylgeranyltransferase type I (GGTase-I)