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Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1. Additionally we are shipping Protein Geranylgeranyltransferase Type I, beta Subunit Proteins (5) and many more products for this protein.
Showing 10 out of 37 products:
Human Polyclonal PGGT1B Primary Antibody for ELISA, WB - ABIN562193
Iguchi, Katsuno, Niwa, Yamada, Sone, Waza, Adachi, Tanaka, Nagata, Arimura, Watanabe, Kaibuchi, Sobue: TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases. in The Journal of biological chemistry 2009
Human Monoclonal PGGT1B Primary Antibody for IF, IHC (p) - ABIN562194
Lee, Chang, Trinh, Tu, White, Davies, Bergo, Fong, Lowry, Young: Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes. in Human molecular genetics 2010
our study showed, for the first time, that HIF-1alpha was regulated by protein prenylation transferase GGTI and mediated the effect of GGTI on glioma cell migration and invasion
our findings identify Geranylgeranyl transferase 1 as a key regulator of human airway smooth muscle cell viability
RNAi knockdown of GGTase-Ibeta inhibited invasion, disrupted F-actin organization and decreased the level of cofilin in PC-3 cells.
results suggest that geranylgeranylation of RhoA is critical for cancer cell invasion
Results suggest that all peptide substrates adopt a common binding mode in the protein farnesyltransferase and geranylgeranyltransferase active site.
The results showed that the magnitude of long-term potentiation (LTP) was markedly suppressed in hippocampal slices from GGT-haplodeficient mice. Consistent with the synaptic dysfunction, there was a significant decrease in cortical spine density and cognitive function in GGT-haplodeficient mice.
This study demonstrated that Inhibiting geranylgeranyltransferase I activity decreases spine density in central nervous system.
A decrease in membrane-associated Rho proteins in aged brain is associated with down-regulation of GGTase-Ibeta.
Targeting GGTase-I activates RHOA and leads to increased macrophage reverse cholesterol transport and reduced atherosclerosis development despite a significant increase in inflammation.
deficiencies in either FTase or GGTase-I lead to severe hepatocellular disease. Our studies lay to rest the earlier notion that FTase is dispensable in adult tissues
Data show that mice lacking GGTase-I in macrophages develop severe joint inflammation resembling erosive rheumatoid arthritis.
Both Fntb and Pggt1b are required for the homeostasis of skin keratinocytes.
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994
protein geranylgeranyltransferase type I, beta subunit
, geranylgeranyl transferase type I subunit beta
, geranylgeranyl transferase type-1 subunit beta
, geranylgeranyltransferase type I beta subunit
, type I protein geranyl-geranyltransferase subunit beta
, geranylgeranyltransferase type 1 beta
, geranylgeranyltransferase type I (GGTase-I)