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The product of P2RY12 belongs to the family of G-protein coupled receptors. Additionally we are shipping P2RY12 Kits (24) and P2RY12 Proteins (4) and many more products for this protein.
Showing 10 out of 37 products:
Human Polyclonal P2RY12 Primary Antibody for IHC (p), WB - ABIN1394995
Garcia-Mesa, Jay, Checkley, Luttge, Dobrowolski, Valadkhan, Landreth, Karn, Alvarez-Carbonell: Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system. in Journal of neurovirology 2016
Human Polyclonal P2RY12 Primary Antibody for DB, ELISA - ABIN4342653
Abbracchio, Burnstock: Purinoceptors: are there families of P2X and P2Y purinoceptors? in Pharmacology & therapeutics 1995
Human Polyclonal P2RY12 Primary Antibody for IHC, IHC (p) - ABIN4342655
Bornø, Ploug, Bune, Rosenmeier, Thaning: Purinergic receptors expressed in human skeletal muscle fibres. in Purinergic signalling 2012
CLEC-2 (show CLEC1B Antibodies) and P2Y12 are required for CpG ODN-induced platelet activation and thrombosis, and might be targeted to prevent adverse events in patients at risk.
Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/P2Y13 (show P2RY13 Antibodies) receptors among BV-2 microglia.
findings not only revealed the critical role of P2Y12 in Th17 differentiation and EAE pathogenesis, but also suggested the promising potential of P2Y12 antagonists in the treatment of autoimmune diseases
P2y12 Receptor Promotes Pressure Overload-Induced Cardiac Remodeling via Platelet-Driven Inflammation in Mice.
In P2Y12(-/-) mice, the growth of syngeneic ovarian cancer tumors was reduced by >85% compared with wild-type (WT) mice. In contrast, there was no difference in tumor growth between P2Y1 (show P2RY1 Antibodies)(-/-) and WT mice.
Vessel wall P2Y12 receptor, which promotes VSMCs migration through cofilin (show CFL1 Antibodies) dephosphorylation, plays a critical role in the development of atherosclerotic lesions.
P2Y12 null mice are refractory to sepsis-induced lung injury, suggesting a key role for activated platelets and the P2Y12 receptor during sepsis.
excessive mechanical stress may induce a sustained release of ADP and promote SMC senescence via P2ry12-dependent sustained Ras activation, thereby contributing to excessive inflammation and degeneration, which provides insights into TAAD formation and progression.
AHR (show AHR Antibodies) and airway inflammation in a mouse model of asthma. P2Y12 can be a novel therapeutic target to the suppression of eosinophils in asthma.
quinine/bupivacaine-sensitive potassium channels are the functional effectors of the P2Y12R-mediated signaling in microglia activation following neuronal injury
miR (show MLXIP Antibodies)-223, miR (show MLXIP Antibodies)-26b, miR (show MLXIP Antibodies)-126 and miR (show MLXIP Antibodies)-140 are expressed at a lower level in platelets and megakaryocytes in type 2 diabetics causing up-regulation of P2RY12 and SELP (show SEPP1 Antibodies) mRNAs that may contribute to adverse platelet function.
The DHA - naringenin hybrid presented triple antiplatelet activity simultaneously targeting PAR-1 (show MARK2 Antibodies), P2Y12 and COX-1 (show COX1 Antibodies) platelet activation pathways
The results suggest that P2Y12 is a useful marker for the identification of human microglia throughout the lifespan. Moreover, P2Y12 expression might help to discriminate activated microglia and infiltrating myeloid cells from quiescent microglia in the human CNS.
P2RY12, the gene related to thrombogenesis was differentially expressed between the left atrium and right atrium in Sinus rhythm and Atrial fibrillation. Therefore, the changes in the expression of these genes were likely involved in the pathophysiology of AF-related thrombus formation.
Abnormalities of P2Y12 receptor include congenital deficiencies or high activity in diseases like diabetes mellitus and chronic kidney disease, exposing such patients to a prothrombotic condition. (Review)
Data suggest that PAR4 (show PAWR Antibodies) and P2Y12 heterodimer internalization/endocytosis is required for beta-arrestin-2 (show ARRB2 Antibodies) recruitment to endosomes and up-regulation of Akt (show AKT1 Antibodies) signaling; activation of PAR4 (show PAWR Antibodies) but not of P2Y12 drives internalization of the PAR4 (show PAWR Antibodies)-P2Y12 heterodimer. (PAR4 (show PAWR Antibodies) = protease-activated receptor 4 (show F2RL3 Antibodies); P2Y12 = purinergic receptor P2Y (show P2RY1 Antibodies), G-protein coupled, 12 protein; Akt (show AKT1 Antibodies) = proto-oncogene (show RAB1A Antibodies) protein c (show PROC Antibodies)-akt (show AKT1 Antibodies))
Studies indicate that purinergic receptor P2Y12 (P2Y12 receptor) gene C34T and G52T polymorphism might be a risk factor for the poor response to the platelet in patients on clopidogrel therapy.
studies describe 2 novel modes of action of ticagrelor, inhibition of platelet ENT1 and inverse agonism at the P2Y12R that contribute to its effective inhibition of platelet activation.
apart from the established association of the CYP2C19 *2 and *3 LOF alleles with high on-treatment platelet reactivity (HTPR), haplotypes of P2RY12 rs6798347, rs6787801, rs6801273, and rs6785930 rather than rs2046934 (T744C) that related to pharmacodynamics of clopidogrel in patients with ACS were independently associated with HTPR
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.
P2Y purinoceptor 12
, ADP-glucose receptor
, G-protein coupled receptor SP1999
, Gi-coupled ADP receptor HORK3
, P2Y12 platelet ADP receptor
, purinergic receptor P2RY12
, putative G-protein coupled receptor