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PYCR2 belongs to the pyrroline-5-carboxylate reductase family. Additionally we are shipping Pyrroline-5-Carboxylate Reductase Family, Member 2 Proteins (14) and and many more products for this protein.
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PYCR2-related syndrome represents a clinically recognizable condition in which PYCR2 mutations lead to protein dysfunction.
It was found that silence of PYCR2 resulted in the decrease of proliferative ability and activation of AMPK/mTOR-induced autophagy of A375 cells. PYCR2 silencing also activated AMPK/mTOR pathway in another melanoma cell line, CHL-1.
Silencing of both PYCR1 and PYCR2 completely abolished anti-oxidation activity of RRM2B, demonstrating a functional collaboration of these metabolic enzymes in response to oxidative stress.
Hypomyelination and the absence of lax caused by previously reported mutations in the gene encoding PYCR2's isozyme, PYCR1, suggesting a unique and indispensable role for PYCR2 in the human CNS during development.
This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene.
pyrroline-5-carboxylate reductase family, member 2
, pyrroline-5-carboxylate reductase 2
, putative pyrroline-5-carboxylate reductase family member 2 variant 1
, P5C reductase 2
, pyrroline 5-carboxylate reductase isoform
, P5CR 2
, pyrroline-5-carboxylate reductase