Quinolinate Phosphoribosyltransferase Proteins (QPRT)

QPRT encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Additionally we are shipping QPRT Antibodies (73) and QPRT Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
QPRT 23475 Q15274
QPRT 67375 Q91X91
QPRT 293504 Q5I0M2
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Top QPRT Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$522.50
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Log in to see 8 to 11 Days
$504.90
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$400.00
Details
Yeast Nematostella vectensis His tag   1 mg Log in to see 60 to 71 Days
$2,762.83
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,794.00
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,794.00
Details

QPRT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Quinolinate Phosphoribosyltransferase (QPRT) Interaction Partners

Human Quinolinate Phosphoribosyltransferase (QPRT) interaction partners

  1. WT1 (show WT1 Proteins) knock-down gave a corresponding decrease in QPRT gene and protein expression. Chromatin-immunoprecipitation revealed WT1 (show WT1 Proteins) binding to a conserved site in the first intron of the QPRT gene.

  2. The structural features, size distribution, heat aggregation and ITC studies of the full-length enzyme and the enzyme lacking helix alpha1 strongly suggest that human QPRT acts as a hexamer for cooperative reactant binding via three dimeric subunits and maintaining stability.

  3. Report of the crystal structure of human QPRT bound to its inhibitor phthalic acid (PHT) and kinetic analysis of PHT inhibition of human QPRT.

  4. QPRT is a potential new marker for the immunohistochemical screening of follicular thyroid nodules.

QPRT Protein Profile

Protein Summary

This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.

Gene names and symbols associated with QPRT

  • quinolinate phosphoribosyltransferase (ECs0113)
  • quinolinate phosphoribosyltransferase (nadC)
  • quinolinate phosphoribosyltransferase (VP2522)
  • nicotinate-nucleotide pyrophosphorylase (STY0167)
  • nicotinate-nucleotide diphosphorylase (nadC)
  • nicotinate-nucleotide diphosphorylase (BJE04_RS13210)
  • carboxylating (nadC)
  • quinolinate phosphoribosyltransferase (QPRT)
  • quinolinate phosphoribosyltransferase (Qprt)
  • 2410027J01Rik protein
  • AI647766 protein
  • ECK0108 protein
  • JW0105 protein
  • QPRTase protein
  • VF2184 protein

Protein level used designations for QPRT

quinolinate phosphoribosyltransferase , QAPRTase , nicotinate-nucleotide pyrophosphorylase (carboxylating) , nicotinate-nucleotide pyrophosphorylase [carboxylating] , nicotinate-nucleotide pyrophosphorylase , QPRTase , quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating))

GENE ID SPECIES
913630 Escherichia coli O157:H7 str. Sakai
948869 Escherichia coli str. K-12 substr. MG1655
1176241 Yersinia pestis CO92
1178543 Vibrio vulnificus CMCP6
1190037 Vibrio parahaemolyticus RIMD 2210633
1246662 Salmonella enterica subsp. enterica serovar Typhi str. CT18
1251663 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
2625587 Vibrio vulnificus YJ016
2767301 Yersinia pestis biovar Microtus str. 91001
2885134 Pectobacterium atrosepticum SCRI1043
2956115 Yersinia pseudotuberculosis IP 32953
3277733 Vibrio fischeri ES114
3332556 Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67
4715853 Yersinia enterocolitica subsp. enterocolitica 8081
6988234 Aliivibrio salmonicida LFI1238
8168296 Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949
23475 Homo sapiens
67375 Mus musculus
293504 Rattus norvegicus
614254 Bos taurus
Selected quality suppliers for QPRT Proteins (QPRT)
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