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RASSF1 encodes a protein similar to the RAS effector proteins. Additionally we are shipping Ras Association (RalGDS/AF-6) Domain Family Member 1 Antibodies (157) and Ras Association (RalGDS/AF-6) Domain Family Member 1 Kits (7) and many more products for this protein.
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No significant differences were presented in DNA methylation (show HELLS Proteins) levels of RASSF1A and ATM (show ATM Proteins) between the sporadic breast cancer cases and the healthy controls.
High Promoter Methylation of RASSF1A gene is associated with Breast Cancer.
Hypermethylation of RASSF1 gene is associated with neuroendocrine tumors.
RACK1 (show GNB2L1 Proteins) associates with MOAP-1 (show MOAP1 Proteins) via electrostatic associations similar to those observed between MOAP-1 (show MOAP1 Proteins)/RASSF1A and MOAP-1 (show MOAP1 Proteins)/TNF-R1 (show TNFRSF1A Proteins). These events illustrate the complex nature of MOAP-1 (show MOAP1 Proteins) regulation and characterizes the important role of the scaffolding protein, RACK1 (show GNB2L1 Proteins), in influencing MOAP-1 (show MOAP1 Proteins) biology.
The present work proved that there was a higher frequency of RASSF1A methylation and a decrease in its serum level in patients with ovarian cancer compared to controls as well as in the high-grade tumor patients compared to low grade ones and also in advanced ovarian tumor stage compared to early stages.
Promoter methylation of RASSF1A can influence sensitivity to oxaliplatin-based chemotherapy, which can be used to predict outcomes for patients with stage II and III Colorectal Cancer
The meta-analysis indicates a role of the RASSF1A promoter hypermethylation from peripheral blood in testicular germ cell tumors.
RASSF1A is a tumour suppressor gene epigenetically dysregulated in NET. Aberrant methylation of RASSF1A has been reported in various tumours, but this is the first report of RASSF1A hypermethylation in TETs.
Study shows that recombinant human bone morphogenetic protein-2 (show BMP2 Proteins) activates hippo signaling through RASSF1 in esophageal cancer cells
There were significant associations between RASSF1A promoter hypermethylation and Oral Cancer risk.RASSF1A promoter hypermethylation exerted higher frequency in the Tongue Tumor than other site tumor in mouth.
RASSF1A is expressed in differentiating stem cells.RASSF1A promotes YAP (show YAP1 Proteins) and p73 (show ARHGAP24 Proteins) binding to differentiation related genes.RASSF1A uncouples Wnt (show WNT2 Proteins) from Hippo signalling and promotes YAP (show YAP1 Proteins) mediated differentiation via p73 (show ARHGAP24 Proteins).
beta-catenin (show CTNNB1 Proteins) was predominantly associated with Na+/H+ exchanger regulating factor 1 (NHERF1 (show SLC9A3R2 Proteins)) in a dynamic context and an increase of its oncogenic function through RAS-association domain family 1, isoform A (RASSF1A) inactivation in liver metastases.
essential role of RASSF1A in regulating TNF-alpha (show TNF Proteins) signalling in cardiomyocytes, with RASSF1A being key in the formation of the TNFR (show TNFRSF1A Proteins) complex and in signal transmission to the downstream targets
RASSF1A may function to interfere and restrict TLR-driven activation of NF-kappaB (show NFKB1 Proteins) and is essential for protection against inflammation-induced injury.
nickel-smelting fumes upregulated the expression of RASSF1A. This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.
Loss of RASSF1A synergizes with deregulated RUNX2 (show RUNX2 Proteins) signaling in tumorigenesis.
Concomitant with the loss of Rassf1a, the loss of p53 (show TP53 Proteins) (which causes unrestrained propagation of tetraploids into aneuploid cells) further undermines genomic stability and accelerates tumorigenesis.
Data show that methylation of CCND-2 (show CCND2 Proteins), p16, RAR-beta (show RARB Proteins) and RASSF-1a was significantly more prevalent in tumor than in normal tissue specimens.
Rassf1A acts as a tumor suppressor gene.
cooperation between inactivation of Rassf1a and Apc (show APC Proteins) resulting in accelerated intestinal tumourigenesis.
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Ras association (RalGDS/AF-6) domain family 1
, Ras association (RalGDS/AF-6) domain family member 1
, ras association domain-containing protein 1
, Ras association domain family 1
, cardiac-specific ras association domain family 1 protein
, pancreas-specific ras association domain family 1 protein
, tumor suppressor protein RDA32
, 123F protein
, RASSF1A tumor suppressor
, protein 123F2