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RASSF1 encodes a protein similar to the RAS effector proteins. Additionally we are shipping Ras Association (RalGDS/AF-6) Domain Family Member 1 Antibodies (155) and Ras Association (RalGDS/AF-6) Domain Family Member 1 Kits (7) and many more products for this protein.
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Low RASSF1A expression is associated with gastric cancer.
methylation of BRCA1, RASSF1A and GSTP1 (show GSTP1 Proteins) was found in 58.23 %, 74.68 % and 59.49 % of tumor tissues and 51.90 %, 63.29 % and 35.44 % of corresponding adjacent tissues, respectively
Our study established that RASSF1A hypermethylation might have a potential value in the clinical diagnosis of colorectal cancer
Effect of decitabine pretreatment on sensitivity of bladder cancer cells towards chemotherapeutic drugs was also studied. Decitabine treatment leads to restoration of RASSF1A, activation of hippo pathway followed by decreased expression of its oncogenic downstream targets (CTGF (show CTGF Proteins) & CYR61 (show CYR61 Proteins)).
the use of RASSF1A promoter methylation could distinguish ovarian cancer and low malignant potential tumors. -RASSF1A promoter methylation may not be correlated with the clinical features and the survival of ovarian cancer patients.
the methylation positive rates of SHOX2 (show SHOX2 Proteins) with RASSF1A in stage III were both higher than the other stages of lung cancer
Tested if RASSF1A polymorphisms associated with ovarian cancer and with tumor grade and stage. Five tagging single nucleotide polymorphisms (SNPs) (rs4688728G>T, rs72932987C>T, rs1989839C>T, rs2073497A>C, and rs2236947A>C) were evaluated. The CT genotype of rs1989839 was associated with the patients with ovarian cancer (P=0.001), and was significantly correlated with tumor grade and stage (P=0.008).
No significant differences were presented in DNA methylation (show HELLS Proteins) levels of RASSF1A and ATM (show ATM Proteins) between the sporadic breast cancer cases and the healthy controls.
High Promoter Methylation of RASSF1A gene is associated with Breast Cancer.
Hypermethylation of RASSF1 gene is associated with neuroendocrine tumors.
RASSF1A is expressed in differentiating stem cells.RASSF1A promotes YAP (show YAP1 Proteins) and p73 (show ARHGAP24 Proteins) binding to differentiation related genes.RASSF1A uncouples Wnt (show WNT2 Proteins) from Hippo signalling and promotes YAP (show YAP1 Proteins) mediated differentiation via p73 (show ARHGAP24 Proteins).
beta-catenin (show CTNNB1 Proteins) was predominantly associated with Na+/H+ exchanger regulating factor 1 (NHERF1 (show SLC9A3R2 Proteins)) in a dynamic context and an increase of its oncogenic function through RAS-association domain family 1, isoform A (RASSF1A) inactivation in liver metastases.
essential role of RASSF1A in regulating TNF-alpha (show TNF Proteins) signalling in cardiomyocytes, with RASSF1A being key in the formation of the TNFR (show TNFRSF1A Proteins) complex and in signal transmission to the downstream targets
RASSF1A may function to interfere and restrict TLR-driven activation of NF-kappaB (show NFKB1 Proteins) and is essential for protection against inflammation-induced injury.
nickel-smelting fumes upregulated the expression of RASSF1A. This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.
Loss of RASSF1A synergizes with deregulated RUNX2 (show RUNX2 Proteins) signaling in tumorigenesis.
Concomitant with the loss of Rassf1a, the loss of p53 (show TP53 Proteins) (which causes unrestrained propagation of tetraploids into aneuploid cells) further undermines genomic stability and accelerates tumorigenesis.
Data show that methylation of CCND-2 (show CCND2 Proteins), p16, RAR-beta (show RARB Proteins) and RASSF-1a was significantly more prevalent in tumor than in normal tissue specimens.
Rassf1A acts as a tumor suppressor gene.
cooperation between inactivation of Rassf1a and Apc (show APC Proteins) resulting in accelerated intestinal tumourigenesis.
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Ras association (RalGDS/AF-6) domain family 1
, Ras association (RalGDS/AF-6) domain family member 1
, ras association domain-containing protein 1
, Ras association domain family 1
, cardiac-specific ras association domain family 1 protein
, pancreas-specific ras association domain family 1 protein
, tumor suppressor protein RDA32
, 123F protein
, RASSF1A tumor suppressor
, protein 123F2