Regenerating Islet-Derived 3 alpha Proteins (REG3A)

REG3A encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. Additionally we are shipping REG3A Antibodies (122) and REG3A Kits (53) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
REG3A 5068 Q06141
REG3A 19694 O09037
REG3A 171162 P35231
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Top REG3A Proteins at antibodies-online.com

Showing 10 out of 26 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
$492.80
Details
Human Cells Mouse His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
Human Cells Rat Fc Tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Escherichia coli (E. coli) Human GST tag   100 μg Log in to see 11 Days
$411.40
Details
Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 11 Days
$581.90
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human REG3a Protein. 100 μg Log in to see 11 to 18 Days
$625.39
Details

REG3A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) , ,

Rat (Rattus) , ,
, ,

Top referenced REG3A Proteins

  1. Human REG3A Protein expressed in Human Cells - ABIN3216396 : Orelle, Keim, Masciotra, Dagorn, Iovanna: Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases. in The Journal of clinical investigation 1993 (PubMed)
    Show all 3 Pubmed References

More Proteins for Regenerating Islet-Derived 3 alpha (REG3A) Interaction Partners

Human Regenerating Islet-Derived 3 alpha (REG3A) interaction partners

  1. Mice with hepatocytes that express hREG3A, which travels to the intestinal lumen, are less sensitive to colitis than control mice. Suggest reduced oxidative stress preserves the gut (show GUSB Proteins) microbiota and its ability to prevent inflammation.

  2. The pancreas reacts to remote lesions and septic insults in mice and rats with increased PSP (show MSMB Proteins) synthesis, while PAP is selectively responsive to septic events. Furthermore, our results suggest that serum PSP (show MSMB Proteins) in septic patients is predominantly derived through an acute phase response of the pancreas.

  3. Data show that interleukin-2 receptor alpha (show IL2RA Proteins), tumor necrosis factor receptor 1 (show TNFRSF1A Proteins), serum STimulation-2 (IL1RL1 (show IL1RL1 Proteins) gene product), and regenerating islet-derived 3-alpha were significantly associated with non-relapse mortality.

  4. skin injury increases IL-36gamma via the activation of TLR3 (show TLR3 Proteins)-SLUG-VDR (show CYP27B1 Proteins) axis and IL-36gamma induces REG3A to promote wound healing

  5. Association between a SNP in the REG3A gene, rs7588571, located upstream of the REG3A gene, and bone marrow transplant outcomes including the incidence of chronic GVHD. Since REG (show EXTL3 Proteins) proteins control intestinal microbiota, and since intestinal dysbiosis is in part responsible for the development of GVHD, findings lead to the concept that REG3A could have some protective effect through the regulation of gut (show GUSB Proteins) microbiota.

  6. Patients with high levels of PAP/REG3A had overall shorter survival as well as poor surgical outcomes with reduced disease-free survival.

  7. Up-regulation of REG3A correlates with colorectal cancer risk.

  8. Regulation network analysis confirmed the cell growth related differentially expressed genes, and further uncovered three transcription factor families with immune functions regulated by REG3A

  9. Reg3A overexpression promoted cell growth in pancreatic cancer. SOCS3 (show SOCS3 Proteins) is a key target in cancer by inhibiting cell growth and inducing apoptosis. SOCS3 (show SOCS3 Proteins) negatively regulated Reg3A-mediated cell growth in pancreatic cancer.

  10. Serum regenerating islet-derived 3-alpha is a biomarker of mucosal enteropathies

Mouse (Murine) Regenerating Islet-Derived 3 alpha (REG3A) interaction partners

  1. skin injury increases IL-36gamma via the activation of TLR3 (show TLR3 Proteins)-SLUG-VDR (show CYP27B1 Proteins) axis and IL-36gamma induces REG3A to promote wound healing

  2. Data show that regenerating islet-derived 3-alpha (REG3alpha) is a plasma biomarker of gastrointestinal tract graft-versus-host disease that can be combined with clinical stage and histologic grade to improve risk stratification of patients.

  3. Reg2 (show FLOT1 Proteins), Reg3alpha, and Reg3beta were abundantly expressed in most acinar cells of the pancreas with clear age-dependent and isoform-specific patterns.

  4. Reg3alpha stimulates beta-cell replication, by activating Akt (show AKT1 Proteins) kinase and increasing the levels of cyclin D1 (show CCND1 Proteins)/CDK4 (show CDK4 Proteins).

Golden Syrian Hamster Regenerating Islet-Derived 3 alpha (REG3A) interaction partners

  1. data suggest that human adult pancreatic ductal cells retain morphogenetic plasticity and demonstrate that a short exposure to INGAP triggers their differentiation into insulin (show INS Proteins)-expressing cells in vitro.

  2. The results indicate that endogenous INGAP plays a "physiological" positive modulatory role in insulin (show INS Proteins) secretion, supporting its possible use in the treatment of prediabetes and Type 2 diabetes.

REG3A Protein Profile

Protein Summary

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. Alternate splicing results in multiple transcript variants that encode the same protein.

Gene names and symbols associated with REG3A

  • regenerating family member 3 alpha (REG3A)
  • regenerating islet-derived 3 alpha (Reg3a)
  • regenerating islet-derived 3 alpha (REG3A)
  • pancreatic beta cell growth factor-like (LOC101829186)
  • AV063448 protein
  • HIP protein
  • HIP/PAP protein
  • INGAP protein
  • PAP protein
  • PAP-H protein
  • PAP1 protein
  • Pap2 protein
  • PapII protein
  • PBCGF protein
  • PTP protein
  • REG-III protein
  • REG3 protein
  • REG3G protein

Protein level used designations for REG3A

PAP homologous protein , REG-3-alpha , hepatocarcinoma-intestine-pancreas , hepatointestinal pancreatic protein , human proislet peptide , pancreatic beta cell growth factor , pancreatitis-associated protein 1 , proliferation-inducing protein 34 , proliferation-inducing protein 42 , reg III-alpha , regenerating islet-derived protein 3-alpha , regenerating islet-derived protein III-alpha , RegIII (alpha) , generating islet-derived, mouse homolog 3 alpha , islet of Langerhans regenerating protein 3 , lithostathine 3 , pancreatitis-associated protein 2 , REG 3 , regIII , regenerating islet-derived protein 3 alpha , ICRF , PSP , REG , islet cells regeneration factor , islet of Langerhans regenerating protein , lithostathine , pancreatic stone protein , pancreatic thread protein , islet neogenesis associated protein , pancreatitis-associated protein , regenerating islet-derived 3 gamma , regenerating islet-derived 3 alpha

GENE ID SPECIES
5068 Homo sapiens
19694 Mus musculus
171162 Rattus norvegicus
404114 Bos taurus
101829186 Mesocricetus auratus
403411 Canis lupus familiaris
459349 Pan troglodytes
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