REG3A Protein (His tag)

Catalog No. ABIN7320383

Product Details

Target: REG3A (Regenerating Islet-Derived 3 alpha (REG3A))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This REG3A protein is labelled with His tag.

Purpose: Recombinant Mouse REG3A/HIP Protein (His Tag)

Sequence: Met1-Gln175

Characteristics: A DNA sequence encoding the extracellular domain (Met1-Gln175) of mouse REG3A (NP_035389.1) precursor was expressed with a C-terminal polyhistidine tag.

Purity: > 95 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: REG3A (Regenerating Islet-Derived 3 alpha (REG3A))

Alternative Name: REG3A/HIP (REG3A Products)

Synonyms: HIP Protein, HIP/PAP Protein, INGAP Protein, PAP Protein, PAP-H Protein, PAP1 Protein, PBCGF Protein, REG-III Protein, REG3 Protein, AV063448 Protein, Pap2 Protein, PapII Protein, PTP Protein, REG3G Protein, regenerating family member 3 alpha Protein, regenerating islet-derived 3 alpha Protein, REG3A Protein, Reg3a Protein

Background:

Background: Regenerating islet-derived protein 3-alpha, also known as Regenerating islet-derived protein III-alpha, REG-3-alpha, REG3A, and HIP, is secreted protein which contains one C-type lectin domain. REG3A is constitutively expressed in intestine, and is a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It is overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis. REG3A and REG1A proteins are both involved in liver and pancreatic regeneration and proliferation. REG3A is also a stress protein involved in the control of bacterial proliferation. REG3A is down-regulated in most primary human gastric cancer cells, and might be useful in the diagnosis of gastric cancer. Additionally, REG3A is a target of beta-catenin signaling in Huh7 hepatoma cells. The REG1A and REG3A are downstream targets of the Wnt pathway during liver tumorigenesis.

Synonym: AV063448,Rega3a

Molecular Weight: 18 kDa

NCBI Accession: NP_035389