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This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases.
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Studied association of and RNASET2, GPR174, and PTPN22 (show PTPN22 Proteins) gene polymorphisms and liver damage(LD) due to Graves' disease (GD) hyperthyroidism. Found GPR174 rs3827440, PTPN22 (show PTPN22 Proteins) rs3789604, and RNASET2 rs9355610 were significantly associated with altered GD-derived LD risk.
RNASET2 is the enzyme that degrades the RNAs
RNASET2, an IBD susceptibility gene, is a component of TL1A (show TNFSF15 Proteins)-mediated pathways regulating cytokine production.
inhibits melanocyte outgrowth through interacting with shootin1 (show KIAA1598 Proteins); this effect may be associated with vitiligo (show MITF Proteins) pathogenesis
Biological features allow to put forward the hypothesis that the RNASET2 protein can act as a molecular barrier for limiting the damages and tissue remodeling events occurring during the earlier step of cell transformation.
RNASET2 may contribute to the development of vitiligo (show MITF Proteins) by inhibiting TNF Receptor-Associated Factor 2 (show TRAF2 Proteins) expression and lead directly to apoptosis of melanocytes
describe a multi-step strategy that allows production of highly pure, catalytically competent recombinant RNASET2 in both wild-type and mutant forms
RNASET2 has antitumorigenic and antiangiogenic activities; a truncated version of human RNASET2, starting at E50 (trT2-50) and devoid of ribonuclease activity, has actin binding and anticancer-related biological activities
RNASET2 tag SNP but not CCR6 polymorphisms is associated with autoimmune thyroid diseases in the Chinese Han population
Results show that downregulation of RNASET2 and GGNBP2 (show GGNBP2 Proteins) in drug-resistant ovarian cancer tissues/cells contributes to the regulation of drug resistance in ovarian cancer.
This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement.
, ribonuclease T2
, polyU-preferential ribonuclease
, RNase Dre2
, ribonuclease t2