RNASET2 Protein (His tag)
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- Target See all RNASET2 Proteins
- RNASET2 (Ribonuclease T2 (RNASET2))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This RNASET2 protein is labelled with His tag.
- Purpose
- Recombinant Human RNASET2 Protein (Human Cells, His Tag)
- Sequence
- Asp25-His256
- Characteristics
- Recombinant Human Ribonuclease T2 is produced by our Mammalian expression system and the target gene encoding Asp25-His256 is expressed with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product RNASET2 Protein
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Ribonuclease T2 (RNASET2) (AA 172-256) protein (His-IF2DI Tag)
RNASET2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Ribonuclease T2 (RNASET2) (AA 1-256) protein (GST tag)RNASET2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Ribonuclease T2 (RNASET2) (AA 25-256) protein (His tag)Crystallography grade RNASET2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Ribonuclease T2 (RNASET2) (AA 30-259) protein (His tag)Crystallography grade RNASET2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Ribonuclease T2 (RNASET2) protein (Myc-DYKDDDDK Tag)RNASET2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM TrisHcl, 150 mM NaCl,20 % Glycerol, pH 7.5.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- RNASET2 (Ribonuclease T2 (RNASET2))
- Alternative Name
- RNASET2 (RNASET2 Products)
- Synonyms
- RNASE6PL Protein, bA514O12.3 Protein, MGC83874 Protein, MGC145364 Protein, dre2 Protein, wu:fc10c06 Protein, zgc:113369 Protein, ribonuclease T2 Protein, ribonuclease T2 L homeolog Protein, ribonuclease t2 Protein, RNASET2 Protein, Rnaset2 Protein, rnaset2.L Protein, rnaset2 Protein, TM1040_2631 Protein, RPE_1409 Protein, Bind_1696 Protein, Dd586_2225 Protein, Nhal_0810 Protein, Snov_2442 Protein, Fbal_2689 Protein, Nitsa_0808 Protein, Mesop_3495 Protein
- Background
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Background: RNASET2 (ribonuclease T2) is an enzyme which belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. This protein can be inhibited by Zn2+ and Cu2+. It has ribonuclease activity, with higher activity at acidic pH and is probably involved in lysosomal degradation of ribosomal RNA. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.
Synonym: Ribonuclease T2,3.1.27.-,Ribonuclease 6,RNASE6PL
- Molecular Weight
- 28.2 kDa
- UniProt
- O00584
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